Twin family registries worldwide

Hur, Yoon‐Mi; Odintsova, Veronika V.; Ordoñana, Juan R.; Silventoinen, Karri; Willemsen, Gonneke

doi:10.1016/b978-0-12-821514-2.00009-x

Cited by 2 publications

(1 citation statement)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In today's globalized and increasingly interconnected research world, collaboration and cooperation are key. Over 60 twin registers are in place worldwide, across multiple continents in 26 countries 110 , with a large number collaborating and sharing the data in the CODATwins project 111 .…”

Section: Discussionmentioning

confidence: 99%

Maximising the Value of Twin Studies in Health and Behaviour

Hagenbeek¹,

Hirzinger²,

Breunig³

et al. 2022

Preprint

View full text Add to dashboard Cite

This contribution considers developments in the field of ‘twin studies’ in times of rapid changes in society, and technological and methodological advances. The classical twin design is of value to emerging and re-emerging phenotypes, including those from evolving omics technologies and offers advances for modeling causality, intergenerational transmission, gene-environment correlation and interaction. We summarize what we have learned about twinning and look at whether twins and twin studies are representative of the general population and cover global diversity. We provide an updated overview of twin concordance and discordance for major diseases and disorders, which convey a crucial message: the genetic code is not as deterministic as often believed. This has important implications for genetic risk prediction tools utilized by researchers and clinicians, as predictions can only go as far as the monozygotic twin concordance rates.

show abstract

Section: Discussionmentioning

confidence: 99%