2016
DOI: 10.1111/dme.13076
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Twin pregnancies complicated by gestational diabetes mellitus: a single centre cohort study

Abstract: Almost 1 in 10 women with a twin pregnancy were diagnosed with gestational diabetes, with the incidence of gestational diabetes increasing threefold with a new screening protocol. The pregnancy outcomes of women with a twin pregnancy did not change with increased detection and treatment for gestational diabetes.

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Cited by 18 publications
(22 citation statements)
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“…GDM has been shown to be a risk factor for pre‐eclampsia in women with singleton 32 and twin pregnancies 3–9 . In the present study, the rate of pre‐eclampsia was higher in women with GDM twins than in women with non‐GDM twins; the difference was close to being statistically significant in the univariable analysis ( P = 0.061).…”
Section: Discussionsupporting
confidence: 66%
“…GDM has been shown to be a risk factor for pre‐eclampsia in women with singleton 32 and twin pregnancies 3–9 . In the present study, the rate of pre‐eclampsia was higher in women with GDM twins than in women with non‐GDM twins; the difference was close to being statistically significant in the univariable analysis ( P = 0.061).…”
Section: Discussionsupporting
confidence: 66%
“…This observation is indirectly supported by the study of Dinham et al [2], who observed an abrupt 3-fold increase in the incidence of GDM in twin pregnancies after using the 1-step approach of the 75 g (similar to the case in singletons), 2-h oral glucose tolerance test that was recommended by the International Association of Diabetes and Pregnancy Study Group [10]. Finally, our study showed that the risk of stillbirths increased 6-fold among the ''diabesity'' group as compared to GDM mothers with an appropriate pre-gravid BMI.…”
Section: Discussionsupporting
confidence: 63%
“…It appeared that the frequency of GDM in twin gestations is not unanimously increased, mainly because of glucose uptake by a higher (nearly double) fetal mass counterbalancing the diabetogenic effects of hyperplacentosis characterizing a multiple pregnancy [1]. However, it was recently found that the new screening protocol increased 3-fold the incidence of diagnosed GDM in twin pregnancies [2], casting some doubt on the true incidence of GDM in twin gestations.…”
Section: Introductionmentioning
confidence: 99%
“…They proposed that a higher 1-h GCT threshold maintained 100% sensitivity with a higher specificity and positive predictive value, thus resulting in fewer patients testing positive. Furthermore, Dinham et al (2016) found little benefit with increased diagnosis and treatment of GDM in twin pregnancies with the new IADPSG criteria. These results suggest that the physiological differences between twin pregnancies and singletons should be considered when assessing glucose tolerance in twin pregnancy.…”
Section: Discussionmentioning
confidence: 98%