Twin Pregnancy discordordant for Downs syndrome: Case Report

Albu, Dinu-Florin; Albu, Cristina-Crenguta; Albu, Stefan-Dimitrie

doi:10.17511/ijmrr.2015.i6.114

Cited by 4 publications

(4 citation statements)

References 15 publications

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“…Considering these observations as well as the application of MSS (AFP, hCG and uE3) in predicting risk for Down syndrome and other congenital anomalies, we started to use in the Clinic of Obstetrics and Gynecology of the Prof. Dr. Panait Sarbu Hospital in Bucharest the serial ultrasound test associated with dosages of AFP, hCG and uE3 [28]. When maternal serum screening is performed for the usual clinical indication , abnormal analyte results can be utilized for the identification of pregnancies at risk and to direct their clinical management [25].…”

Section: Resultsmentioning

confidence: 99%

Impact of Material Serum Screening in Early Prenatal Diagnosis and Management of Congenital Anomalies

Albu¹,

Cilievici²,

Albu³

et al. 2019

Rev. Chim.

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It was performed a case-control study, that included totally 187 pregnant women hospitalized in Obstetrical-Gynecology Department of Prof. Dr. Panait Sarbu Hospital, Bucharest, Romania. The selection criteria for case sample were: age over 30 years, history of malformative risk, clinical exam that emphasised malformations and ultrasound examination that suspicioned embrio-fetal morphological abnormalities. We determined the serum levels of alpha fetoprotein (AFP), human chorionic gonadotropin (hCG) and unconjugated estriol (uE3), by immunoenzymometry. As statistical analysis we determined the estimated median value. For each of the three parametres, the final curve was compared with the value obtained by spectrophotometry. The study revealed the predictive value of correlated use of these three parameters, together with ultrasound examination and cytogenetic investigations, in order to early prenatal diagnosis of congenital fetal anomalies.

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Section: Resultsmentioning

confidence: 99%

Impact of Material Serum Screening in Early Prenatal Diagnosis and Management of Congenital Anomalies

Albu¹,

Cilievici²,

Albu³

et al. 2019

Rev. Chim.

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“…Fetal SCT is usually reported in singleton pregnancy.Few literatures reported STC in one twin in twin pregnancy. We performed an extensive search and make a literature review in English and Chinese and found fewer than 9 cases of SCT in one twin had been reported [ 10 , 17 – 22 ]. Detailed information are showed in Table 1 .…”

Section: Discussionmentioning

confidence: 99%

Sacrococcygeal teratoma in one twin: a case report and literature review

Yan

Liao

et al. 2020

BMC Pregnancy Childbirth

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Background Sacrococcygeal teratoma is one of the most common congenital tumors in newborns and infancy. The incidence is 1 per 20,000–40,000 live births. Ultrasonography is an optimal method for prenatal screening and diagnosis of fetal sacrococcygeal teratoma. MRI can be used to assist in the diagnosis. However, sacrococcygeal teratoma in the twin pregnancy is rare. Case presentation We reported a case of one twin with sacrococcygeal teratoma in dichorionic-diamniotic twin pregnancy.One twin with sacrococcygeal teratoma was diagnosed at the second trimester by ultrasonic examination and another twin was normal. A regular and careful antenatal care was conducted by the multidisciplinary team. The parents refused to perform the fetal MRI and examine the chromosome of both twin.At 37 + 1 of gestation, planned cesarean section was performed. The healthy male co-twin (twin A) weighed 2880 g.The male twin with SCT (twin B) weighed 2900 g, complying with 6 × 3 × 3 cm cystic and solid mass in sacrococcygeal region. At four days of age twin B underwent excisional surgery of the sacrococcygeal teratoma and coccyx and discharged 7 days after surgery. The mother and both babies were followed up and are all in good health until now. Conclusion(s) Sacrococcygeal teratoma in twin pregnancy is rare. Early antenatal diagnosis is important. Once the sacrococcygeal teratoma is diagnosed, clinicians should be aware of the associated maternal and fetal complications. Expecting parents should be counseled by the multidisciplinary team about the management and prognosis of the STC twin and co-twin. Prompt surgical excision of the sacrococcygeal teratoma after birth should be suggested.

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“…The risk of giving birth to a child with Down syndrome increases with the mother's age [28]. Thus, the risk of mothers under 29 is 1 / 3,000 births, at 30 it increases sharply to 1/700, and at 45 the risk is almost unacceptable, being 1/40 of births [28,[31][32][33].…”

Section: Mthfr C677t Gene Mutation and Maternal Risk Of Down Syndromementioning

confidence: 99%

Folic acid and its implications in genetic pathology

Albu¹,

Albu²,

Russu³

et al. 2022

World J. Adv. Res. Rev.

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Vitamins are essential for the proper functioning of the body, and Folic Acid, also known as Vitamin B9, has many benefits for the body. Folic Acid contributes to the normal development of the fetus, preventing the risk of fetal birth defects, mainly represented by neural tube defects and orofacial clefts. At the same time, Folic Acid deficiency can cause serious health problems. That is why it is necessary to know the roles of Folic Acid in the body, the symptoms of Folic Acid deficiency, but also what foods are rich in Folic Acid and how to supplement the body's need for Folic Acid.

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Twin Pregnancy discordordant for Downs syndrome: Case Report

Abstract: The work presented is a clinical and genetical trial of a couple with a reproductive failure and a family history of chromosomal abnormalities. The most reliable and accurate methods used for antenatal diagnosis of Down syndrome fetuses are highlighted.

Cited by 4 publications

References 15 publications

Impact of Material Serum Screening in Early Prenatal Diagnosis and Management of Congenital Anomalies

Impact of Material Serum Screening in Early Prenatal Diagnosis and Management of Congenital Anomalies

Sacrococcygeal teratoma in one twin: a case report and literature review

Folic acid and its implications in genetic pathology

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