To predict the maneuverability of a dual full rotary propulsion ship quickly and accurately, the integrated computational fluid dynamics (CFD) and mathematical model approach is performed to simulate the ship turning and zigzag tests, which are then compared and validated against a full-scale trial carried out under actual sea conditions. Initially, the RANS equations are solved, employing the Volume of Fluid (VOF) method to capture the free water surface, while a numerical simulation of the captive model test is conducted using the rigid body motion module. Secondly, hydrodynamic derivatives for the MMG model are obtained from the CFD simulations and empirical formula. Lastly, a four-degree-of-freedom mathematical model group (MMG) maneuvering model is proposed for the dual full rotary propulsion ship, incorporating full-scale simulations of turning and zigzag tests followed by a full-scale trial for comparative validation. The results indicate that the proposed method has a high accuracy in predicting the maneuverability of dual full-rotary propulsion ships, with an average error of less than 10% from the full-scale trial data (and within 5% for the tactical diameters in particular) in spite of the influence of environmental factors such as wind and waves. It provides experience in predicting the maneuverability of a full-scale ship during the ship design stage.