Twin Spotting − A Rare Association with Congenital Melanocytic Nevus and Nevus Depigmentosus

Multiple Hypo- and Hyper-Pigmentation

“…The twin spots have been suggested for the combination of leukoderma and CALS in Bloom's syndrome, lentiginosis and nevus depigmentosus, congenital melanocytic nevus and nevus depigmentosus, as well as nevus telangiectaticus and nevus anemicus. [ 5 6 ] Both different lesions have different recessive mutations occurring on the same chromosome and manifest visibly only in the rare event of somatic recombination occurring at an early developmental stage. This hypothesis requires further genetic studies involving more patients.…”