Twin studies in inherited eye disease

Abstract

Eye diseases represent a significant source of health impairment in humans. Twin studies offer an excellent model to dissect the genetic basis of human diseases. In this review, we discuss the potential advantages of using twin-based studies in investigating the genetics of eye diseases--from heritability estimation to identifying underlying genetic and epigenetic changes. We also discuss some of the notable findings of twin studies exploring the genetics of eye diseases. Finally, we suggest other novel approaches that can be utilized to tap the potential of twin studies to provide a more complete understanding of genetic factors underlying ocular diseases.

Art for Twins: Yorùbá Artists and Their Statues/Twin Research Studies: Twins’ Education and Conceptions; Diurnal Preference; Inherited Eye Diseases; Ultrasound Counseling When Twins Are Conjoined/Popular Twin Reports: Twin Sisters (the Film); Rare Pregnancy; Diet Test; French Twins Reared Apart and Reunited

“…It is estimated that 259,000,000 people worldwide suffer from some form of visual impairment. Thus, a current comprehensive review of twin studies of inherited eye diseases is a welcome addition to the twin-based medical literature (Nag & Hammond, 2014). The review covers the logic of the twin design, heritability studies of ocular disorders, and various approaches to discovering genes associated with them.…”