TwinsMX: Uncovering the Basis of Health and Disease in the Mexican Population

Leon-Apodaca, Ana V.; Chiu-Han, Enrique; Ortega-Mora, Ivett; Román-López, Talía V.; Caballero-Sánchez, Ulises; Aldana-Assad, Oscar; Campos, Adrián I.; Cuéllar-Partida, Gabriel; Ruiz-Contreras, Alejandra E.; Alcauter, Sarael; Rentería, Miguel E.; Medina-Rivera, Alejandra

doi:10.1017/thg.2019.112

Cited by 11 publications

(7 citation statements)

References 32 publications

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“…Data used for this study comes from the Mexican Twin Registry, TwinsMX (https://twinsmxofficial.unam.mx/; Leon-Apodaca et al, 2019), collected using the Research Electronic Data Capture (REDCap) platform, hosted at the National Laboratory of Advanced Scientific Visualization at the Universidad Nacional Autónoma de México (UNAM). All participants gave informed consent, and the study protocol was reviewed and approved by the Research Ethics Committee of the Institute of Neurobiology at UNAM.…”

Section: Samplementioning

confidence: 99%

Estimating the Genetic Contribution to Astigmatism and Myopia in the Mexican Population

Román-López,

García-Vilchis,

Murillo-Lechuga

et al. 2023

Twin Res Hum Genet

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Astigmatism and myopia are two common ocular refractive errors that can impact daily life, including learning and productivity. Current knowledge suggests that the etiology of these conditions is the result of a complex interplay between genetic and environmental factors. Studies in populations of European ancestry have demonstrated a higher concordance of refractive errors in monozygotic (MZ) twins compared to dizygotic (DZ) twins. However, there is a lack of studies on genetically informative samples of multi-ethnic ancestry. This study aimed to estimate the genetic contribution to astigmatism and myopia in the Mexican population. A sample of 1399 families, including 243 twin pairs and 1156 single twins, completed a medical questionnaire about their own and their co-twin’s diagnosis of astigmatism and myopia. Concordance rates for astigmatism and myopia were estimated, and heritability and genetic correlations were determined using a bivariate ACE Cholesky decomposition method, decomposed into A (additive genetic), C (shared environmental) and E (unique environmental) components. The results showed a higher concordance rate for astigmatism and myopia for MZ twins (.74 and .74, respectively) than for DZ twins (.50 and .55). The AE model, instead of the ACE model, best fitted the data. Based on this, heritability estimates were .81 for astigmatism and .81 for myopia, with a cross-trait genetic correlation of rA = .80, nonshared environmental correlation rE = .89, and a phenotypic correlation of rP = .80. These results are consistent with previous findings in other populations, providing evidence for a similar genetic architecture of these conditions in the multi-ethnic Mexican population.

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Section: Samplementioning

confidence: 99%

Estimating the Genetic Contribution to Astigmatism and Myopia in the Mexican Population

Román-López,

García-Vilchis,

Murillo-Lechuga

et al. 2023

Twin Res Hum Genet

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“…A profile of QoL perception was generated; environmental, physical, psychological, and social domains were evaluated, as well as overall quality of life and health perception; this profile was compared with two groups of non-SLE subjects: the first group was integrated using non-SLE individuals registered on the Lupus RGMX platform, invited directly by the SLE participants and through social media. The second group was identified from the Mexican Registry of Twins (Twins MX) a registry previously established by the Neurogenomics consortium, of which Lupus RGMX is part, that shares the design and surveys with Lupus RGMX (Leon-Apodaca et al, 2019); for this analysis only one individual per family was considered.…”

Section: Quality Of Lifementioning

confidence: 99%

Lupus RGMX: Social and Clinical Characteristics and their Contribution to Quality of Life in a Mexican Cohort with SLE

Hernández-Ledesma

Martínez

Fajardo-Brigido

et al. 2023

Preprint

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BACKGROUND. Although higher prevalence, disease activity, damage accumulation and mortality of systemic lupus erythematosus (SLE) are observed among Latin American, North American admixed population, African descendants and Native Americans, the information about SLE in Latin American countries, such as Mexico, is scarce. OBJECTIVES. To present Lupus RGMX, a multidisciplinary effort to generate a national digital patient registry to enrich the understanding of Mexican people with SLE. METHODS. Mexican patients with SLE registered between May 2021 and January 2023 in Lupus RGMX were included. Sociodemographic, socioeconomic and clinical characteristics, along with quality of life perception (QoL) were assessed using self-reported data. We compared the QoL obtained from patients with SLE with two groups of non-SLE Mexican subjects. Descriptive statistics, comparisons analyses and a multivariate nonparametric regression model were performed. RESULTS. A total of 1172 of lupus patients were included; of which 93.9% were women. The mean age±SD was 36.6±10.7 years, with 37.1% of the individuals between 41 and 50 years. The 24.9% reported a calculated monthly income of 430 USD (8,612 MXN). Lower QoL scores were observed in the SLE group, especially in subjects with lower socioeconomic level. Health perception, QoL perception and socioeconomic status were the variables with greater importance to predict total WHOQoL scores. CONCLUSION. The design and implementation of Lupus RGMX imply a pioneering approach to unraveling SLE in Mexicans. Further studies from Lupus RGMX will be focused on enriching the representation of the Mexican population and include other aspects that may allow us to improve our understanding of the disease in our population.

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“…The consortium is currently focused on three traits in the admixed Mexican population: (a) twins and members of multiple births (TwinsMX) ( 37 ), (b) people with Systemic Lupus Erythematosus (LupusRGMX) ( 38 ), and (c) patients with Parkinson Disease (MEX-PD) ( 39 ). There is a lack of other nationwide registries that include genetic data and publicly available information characterizing Mexican people with these traits.…”

Section: Introductionmentioning

confidence: 99%

Building national patient registries in Mexico: insights from the MexOMICS Consortium

Reyes-Pérez,

Hernández-Ledesma,

Román-López

et al. 2024

Front. Digit. Health

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ObjectiveTo introduce MexOMICS, a Mexican Consortium focused on establishing electronic databases to collect, cross-reference, and share health-related and omics data on the Mexican population.MethodsSince 2019, the MexOMICS Consortium has established three electronic-based registries: the Mexican Twin Registry (TwinsMX), Mexican Lupus Registry (LupusRGMX), and the Mexican Parkinson's Research Network (MEX-PD), designed and implemented using the Research Electronic Data Capture web-based application. Participants were enrolled through voluntary participation and on-site engagement with medical specialists. We also acquired DNA samples and Magnetic Resonance Imaging scans in subsets of participants.ResultsThe registries have successfully enrolled a large number of participants from a variety of regions within Mexico: TwinsMX (n = 2,915), LupusRGMX (n = 1,761) and MEX-PD (n = 750). In addition to sociodemographic, psychosocial, and clinical data, MexOMICS has collected DNA samples to study the genetic biomarkers across the three registries. Cognitive function has been assessed with the Montreal Cognitive Assessment in a subset of 376 MEX-PD participants. Furthermore, a subset of 267 twins have participated in cognitive evaluations with the Creyos platform and in MRI sessions acquiring structural, functional, and spectroscopy brain imaging; comparable evaluations are planned for LupusRGMX and MEX-PD.ConclusionsThe MexOMICS registries offer a valuable repository of information concerning the potential interplay of genetic and environmental factors in health conditions among the Mexican population.

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TwinsMX: Uncovering the Basis of Health and Disease in the Mexican Population

Cited by 11 publications

References 32 publications

Estimating the Genetic Contribution to Astigmatism and Myopia in the Mexican Population

Estimating the Genetic Contribution to Astigmatism and Myopia in the Mexican Population

Lupus RGMX: Social and Clinical Characteristics and their Contribution to Quality of Life in a Mexican Cohort with SLE

Building national patient registries in Mexico: insights from the MexOMICS Consortium

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