2013
DOI: 10.1002/cncr.28404
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TWIST1 is a molecular marker for a poor prognosis in oral cancer and represents a potential therapeutic target

Abstract: BACKGROUND: Locoregional recurrence and distant metastases are ominous events in patients with advanced oral squamous cell carcinoma (OSCC). The objective of this study was to identify functional biomarkers that are predictive of OSCC progression to metastasis. METHODS: The expression profile of a network of epithelial-mesenchymal transition (EMT) genes was investigated in a large cohort of patients with progressive OSCC using a complimentary DNA microarray platform coupled to quantitative reverse transcriptas… Show more

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Cited by 53 publications
(55 citation statements)
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“…Dysregulation of Twist1 expression and function was also related with tumor invasion and metastasis in several solid cancers, such as oral cancer [30], esophageal squamous cell carcinoma [31], prostate cancer [32], as well as HCC [33,34]. In the present study, the ectopic expression or targeted knock down of SOX5 resulted in increased or decreased expression of Twist1.…”
Section: Discussionmentioning
confidence: 69%
“…Dysregulation of Twist1 expression and function was also related with tumor invasion and metastasis in several solid cancers, such as oral cancer [30], esophageal squamous cell carcinoma [31], prostate cancer [32], as well as HCC [33,34]. In the present study, the ectopic expression or targeted knock down of SOX5 resulted in increased or decreased expression of Twist1.…”
Section: Discussionmentioning
confidence: 69%
“…Apart from physical alterations, E-cadherin could induce EMT by induction of transcription factor such as Twist [21]. Twist is usually associated with the advanced cancers and linked with the positive lymph node, lung metastasis, and poor survival of oral squamous cell carcinoma patients [22]. …”
Section: Epithelial-mesenchymal Transition (Emt) and E-cadherinmentioning
confidence: 99%
“…The classical subtype is characterized by overexpression of genes related to oxidative stress response and xenobiotic metabolism, and is most strongly associated with tobacco exposure. Deregulation of the KEAP1/NRF2 oxidative stress pathway appears to be a critical element of carcinogenesis in the classical subtype, and there is growing evidence to suggest that the KEAP1‐NRF2 mediated oxidative stress response plays a role in resistance to radiation in several human cancers . The atypical subtype is characterized by elevated expression of CDKN2A, LIG1 , and RPA2 , and has also been associated with low EGFR expression …”
Section: Introductionmentioning
confidence: 99%