Using the framework for multiplicative parametrized homotopy theory introduced in joint work with C. Schlichtkrull, we produce a multiplicative comparison between the homotopical and operator algebraic constructions of twisted K-theory, both in the real and complex case. We also improve several comparison results about twisted K-theory of $$C^*$$
C
∗
-algebras to include multiplicative structures. Our results can also be interpreted in the $$\infty $$
∞
-categorical setup for parametrized spectra.