Two Active Learning Models of Protein Dynamics for Use in Undergraduate Biochemistry Courses

Abstract

Dynamic biochemical processes are often difficult for students to grasp in the classroom using static images or models, or even through watching simulation videos. This is particularly true for protein-folding and enzyme catalysis, two key biochemistry concepts. The author has developed and tested two 3D, dynamic, and interactive classroom models, one for protein-folding using interlocking building blocks, and one for enzyme catalysis using modeling clay. Presented here are the design and classroom implementation of the models, as well as student assessment data and feedback. Following classroom instruction, which includes the models, students show understanding of the learning objectives based on exam scores.

Exploring the Structure of Proteins and Other Biomolecules with a VR Museum: Lessons in Classroom Integration

“…However, the use of 2D images does not allow students to fully appreciate the reality of these 3D structures. While small molecules can be aptly represented with physical models using molecular modeling kits, larger structures such as proteins are difficult to display in three dimensions, although such 3D representations are the best way to bridge the spatial manipulation gap. − This leaves two-dimensional representations of crystal structures, electron microscopy images, and cartoon depictions as the primary examples used by instructors in courses like Biochemistry and often leads to difficulty as students attempt to learn key concepts (such as protein folding, binding interactions, or conformational change) without a way to visualize the molecules in three dimensions.…”