Two administrations of an intravaginal progesterone device on the induction of ovarian cyclicity in anestrous mares

Polo, Gina; Weiss, Romildo Romualdo; Bertol, M E Formighieri; Polasek, Thalita Capalbo Milléo; Lima, L G V De; Kozicki, Luiz Ernandes; Dell’Aqua, J.A.; Camargo, Carlos Eduardo; Segui, Marcio Saporski; Macan, Rodrigo Chaves; Alberini, V; Ladewig, Emma L

doi:10.21836/pem20160304

Cited by 5 publications

(5 citation statements)

References 20 publications

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“…PRID has been applied in mares for reversal of anoestrus (Arbeiter et al., 1994; Kaercher et al., 2013) in the transitional phase or in synchronization of oestrus and ovulation (Polo et al., 2016). After the insertion of PRID, there is the emergence of a new follicular wave, with a follicle reaching the dominance phase and resulting in ovulation, making TAI possible (Arbeiter et al., 1994; Polasek et al., 2017).…”

Section: Discussionmentioning

confidence: 99%

“…The use of PRID helps revert anoestrus and/or the transitional period in mares (Polo et al., 2016), and allows an alternative for the synchronization of ovulation. After removal of PRID, follicular follow‐up until the time of ovulation induction can take 3–8 days, and the embryo recovery rate can reach 75% in inseminated mares (Oliveira Filho et al., 2012; Polasek et al., 2017).…”

Section: Introductionmentioning

confidence: 99%

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Timed artificial insemination in crossbred mares: Reproductive efficiency and costs

Macan

Camargo

Zielinski

et al. 2021

Reprod Domestic Animals

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Timed artificial insemination (TAI) has boosted the use of conventional artificial insemination (CAI) by employing hormonal protocols to synchronize oestrus and ovulation. This study aimed to evaluate the efficiency of a hormonal protocol for TAI in mares, based on a combination of progesterone releasing intravaginal device (PRID), prostaglandin (PGF2α) and human chorionic gonadotropin (hCG); and compare financial costs between CAI and TAI. Twenty‐one mares were divided into two groups: CAI group (CAIG; n = 6 mares; 17 oestrous cycles) and TAI group (TAIG; n = 15 mares; 15 oestrous cycles). The CAIG was subjected to CAI, involving follicular dynamics and uterine oedema monitoring with ultrasound examinations (US), and administration of hCG (1,600 IU) when the dominant follicle (DF) diameter's ≥35 mm + uterine oedema + cervix opening. The AI was performed with fresh semen (500 × 106 cells), and embryo was recovered on day 8 (D8) after ovulation. In TAI, mares received 1.9 g PRID on D0. On D10, PRID was removed and 6.71 mg dinoprost tromethamine was administered. Ovulation was induced on D14 (1,600 IU of hCG) regardless of the DF diameter's, and AI was performed with fresh semen (500 × 106 cells). On D30 after AI, pregnancy was confirmed by US. The pregnancy rate was 80.0% in TAIG and 82.3% in CAIG (p > .05). The TAI protocol resulted in 65% reduction in professional transport costs, and 40% reduction in material costs. The TAI was as efficient as CAI, provided reduction in costs and handlings, and is recommended in mares.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Timed artificial insemination in crossbred mares: Reproductive efficiency and costs

Macan

Camargo

Zielinski

et al. 2021

Reprod Domestic Animals

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“…Therefore, mares were resynchronized three days after the onset of synchronization with IPRD, and all mares had endometrial edema after estrogen treatment. Previous studies, treating seasonal transitional mares with IPRD to hasten cyclicity, demonstrated that mares display endometrial edema and estrus after IPRD removal [ 19 , 20 , 21 , 22 , 46 ]. In clinical practice, it is well-known that mares treated with long-acting altrenogest or LAP4 do not respond to estrogen treatment at the onset of a new synchronization protocol.…”

Section: Discussionmentioning

confidence: 99%

“…The IPRD are typically made with a silicon matrix loaded with non-synthetic, free (non-bound) progesterone. In horses, IPRD have been used to hasten cyclicity in transitional mares, and to inhibit estrus in cyclic mares [ 19 , 20 , 21 , 22 , 23 ]. Once inserted, IPRD devices rapidly increase progesterone concentration in plasma [ 22 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Use of Intravaginal Progesterone-Releasing Device Results in Similar Pregnancy Rates and Losses to Long-Acting Progesterone to Synchronize Acyclic Embryo Recipient Mares

Segabinazzi

Andrade

Alvarenga

et al. 2021

Veterinary Sciences

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The objectives of this study were: (1) to assess uterine features and serum progesterone concentrations of acyclic mares synchronized and resynchronized with intravaginal progesterone release device (IPRD), and (2) to compare pregnancy rates and losses of cyclic and acyclic embryo recipient mares treated with different synchronization protocols. In Experiment 1, mares (n = 12) received estradiol for 3 days (E2-3d), and then 24 h after the last injection, an IPRD was inserted and kept in place for 9 days. Three days after IPRD removal, mares were treated with E2-3d, and then a new IPRD was inserted and maintained for three days. Serum progesterone concentrations were assessed 2, 6, and 12 h after insertion and removal of IPRD, and then daily from the insertion of the first IPRD to one day after removal of the second IPRD. Experiment 2 was conducted with embryo recipient mares randomly assigned to four groups: (1) Cyclic: mares (n = 75) had ovulation confirmed after receiving a single dose of histrelin when a periovulatory follicle was first detected, (2) LAP4: acyclic mares (n = 92) were treated with E2-3d and then administered a single dose of LAP4 24 h after the last estradiol injection, (3) IPRD: acyclic mares (n = 130) were treated with E2-3d and an IPRD for 4–8 days, and (4) RE-IPRD: acyclic mares (n = 32) were synchronized as in the IPRD group but not used for embryo transfer (ET), then 8 to 15 days later, the mares were resynchronized with E2-3d and an IPRD for 4–8 days. In vivo-produced Day-8 embryos were collected and transferred 4–8 days after ovulation or progesterone treatments. Mares in IPRD and RE-IPRD groups had the intravaginal device removed immediately before ET, and then a new IPRD was inserted right after ET. Pregnancy diagnosis was performed at 5, 30, and 60 days after ET. Once pregnancy was confirmed, mares in the three acyclic groups received weekly injections of LAP4 (1.5 g) until 120 days of pregnancy. Mares in IPRD and RE-IPRD groups had the device removed three days after the first pregnancy diagnosis. In Experiment 1, progesterone concentrations increased rapidly starting 2 h after insertion of IPRD (p < 0.05); then, concentrations plateaued well above pregnancy maintenance until removal on days 9 and 3, respectively. Progesterone concentrations were reduced to baseline 24 h after IPRD removal (p < 0.05). For experiment 2, there was no difference in pregnancy rates across groups (65–74%) or pregnancy losses by 60 days of gestation (7–12%) (p > 0.05). In conclusion, the IPRD used herein resulted in a rapid increase and a sharp decline in progesterone concentrations upon its insertion and removal, respectively. Finally, our results demonstrated that IPRD could be a compatible alternative to LAP4 to synchronize and resynchronize acyclic embryo recipient mares.

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“…A new follicular wave emerges about 3.5 to 5 days after estradiol benzoate administration (Moreno et al 2001, Bó et al 2002. The PRIDs have been used in horses in the anoestrus phase (Polo et al 2016) or the transitional phase at the beginning of the breeding season, aiming to synchronise the first ovulation, anticipating the beginning of the season (Wilde et al 2002, Handler et al 2007, Hanlon and Firth 2012.…”

Section: Introductionmentioning

confidence: 99%

Two hormonal protocols for timed artificial insemination in mares under different residence times of the progesterone intravaginal device

Zielinski¹,

Camargo²,

Filho³

et al. 2021

PHK

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Two administrations of an intravaginal progesterone device on the induction of ovarian cyclicity in anestrous mares

Cited by 5 publications

References 20 publications

Timed artificial insemination in crossbred mares: Reproductive efficiency and costs

Timed artificial insemination in crossbred mares: Reproductive efficiency and costs

Use of Intravaginal Progesterone-Releasing Device Results in Similar Pregnancy Rates and Losses to Long-Acting Progesterone to Synchronize Acyclic Embryo Recipient Mares

Two hormonal protocols for timed artificial insemination in mares under different residence times of the progesterone intravaginal device

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