Two and three way spectrophotometric-assisted multivariate determination of linezolid in the presence of its alkaline and oxidative degradation products and application to pharmaceutical formulation

Hegazy, Maha A.; Eissa, Maya S.; El-Sattar, O. I. Abd; El-Kawy, Mohammad Abd

doi:10.1016/j.saa.2014.02.140

Cited by 12 publications

(5 citation statements)

References 36 publications

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“…The most frequently employed inverse least squares for building multivariate calibration models are PCR and PLS [ 23 – 25 ]. In the statistical study of spectra, PLS and PCR algorithms are frequently employed to extract detailed data from more general data [ 26 , 27 ]. The PLS and PCR algorithms simultaneously consider the data about replies and levels [ 28 , 29 ].…”

Section: Resultsmentioning

confidence: 99%

Univariate versus multivariate spectrophotometric data analysis of triamterene and xipamide; a quantitative and qualitative greenly profiled comparative study

et al. 2023

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Triamterene (TRI) and xipamide (XIP) mixture is used as a binary medication of antihypertension which is considered as a major cause of premature death worldwide. The purpose of this research is the quantitative and qualitative analysis of this binary mixture by green univariate and multivariate spectrophotometric methods. Univariate methods were zero order absorption spectra method (D0) and Fourier self-deconvolution (FSD), as TRI was directly determined by D0 at 367.0 nm in the range (2.00–10.00 µg/mL), where XIP show no interference. While XIP was determined by FSD at 261.0 nm in the range (2.00–8.00 µg/mL), where TRI show zero crossing. Multivariate methods were Partial Least Squares, Principal Component Regression, Artificial Neural Networks, and Multivariate Curve Resolution-Alternating Least Squares. A training set of 25 mixtures with different quantities of the tested components was used to construct and evaluate them, 3 latent variables were displayed using an experimental design. A set of 18 synthetic mixtures with concentrations ranging from (3.00–7.00 µg/mL) for TRI and (2.00–6.00 µg/mL) for XIP, were used to construct the calibration models. A collection of seven synthetic mixtures with various quantities was applied to build the validation models. All the proposed approaches quantitative analyses were evaluated using recoveries as a percentage, root mean square error of prediction, and standard error of prediction. Strong multivariate statistical tools were presented by these models, and they were used to analyze the combined dosage form available on the Egyptian market. The proposed techniques were evaluated in accordance with ICH recommendations, where they are capable of overcoming challenges including spectral overlaps and collinearity. When the suggested approaches and the published one were statistically compared, there was no discernible difference between them. The green analytical method index and eco-scale tools were applied for assessment of the established models greenness. The suggested techniques can be used in product testing laboratories for standard pharmaceutical analysis of the substances being studied.

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Section: Resultsmentioning

confidence: 99%

Univariate versus multivariate spectrophotometric data analysis of triamterene and xipamide; a quantitative and qualitative greenly profiled comparative study

et al. 2023

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“…Due to its chemical structure, LNZ is highly unstable under alkaline conditions and several degradation studies have been done to evaluate the compounds obtained under conditions of alkaline stress. Alkaline degradation and photodegradation products have been investigated by chromatography and spectrophotometry in LNZ commercial (tablets) and injectable samples (Bebawy, 2003;Lopes, Salgado, 2009;Lopes, Salgado, 2010;Kawy, Weshahy, Shokry, 2012;Hegazy et al, 2014). Chiral impurities from LNZ have been analyzed by MEKC in linezolid solution for infusion (Michalska, Pajchel, Tyski, 2008b).…”

Section: Introductionmentioning

confidence: 99%

Stability-indicating capillary zone electrophoresis assay for the analysis of linezolid in tablets

Oliveira

Salgado

Moraes

2018

Braz. J. Pharm. Sci.

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A simple and fast alternative methodology using capillary zone electrophoresis (CZE) to analyze linezolid and its cationic photodegradation products in tablets has been developed. The separation was carried out on fused silica capillary and conducted using 100 mM formic acid (pH 3.0) and by applying 30 KV voltage. Detection was performed at UV 254 nm. The optimized method was validated in terms of linearity, limits of detection and quantification, precision (repeatability), stability studies (selectivity) and accuracy. Good linearity (8-20 mg L -1 ) was obtained and the limit of detection was 0.95 mg L -1 . The greatest advantages of the CZE method were the rapid set-up of instrumentation and capillary equilibration, short analysis time (12 min), low running cost and low waste generation. The method showed good stability in determining linezolid submitted to degradation by light and to a climatic chamber and can be used as an alternative for evaluation in stability studies of linezolid in tablets, as well as for the analysis of the drug in raw materials and finished products.

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“…The volume of distribution is between 40 and 50% and corresponds to total body water. The drug is eliminated via renal and nonrenal routes with a terminal plasma elimination half-life between 4.5 and 5.5 h. 3 Reviewing the analytical literature for LIN determination reveals several methods such as liquid chromatographic methods for quantitation of LIN in tablets and in biological uids; 2,[4][5][6][7][8][9][10][11][12] for example, a chiral liquid chromatography method has been reported 13 along with TLC densitometry, HPLC [14][15][16][17] and capillary zone electrophoresis. 18,19 Voltammetric methods have also been utilised for LIN determination 20,21 and such an approach has the potential to provide a portable, rapid, sensitive and cost-effective sensor.…”

Section: Introductionmentioning

confidence: 99%

Electroanalytical sensing of the antimicrobial drug linezolid utilising an electrochemical sensing platform based upon a multiwalled carbon nanotubes/bromocresol green modified carbon paste electrode

2016

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Two and three way spectrophotometric-assisted multivariate determination of linezolid in the presence of its alkaline and oxidative degradation products and application to pharmaceutical formulation

Cited by 12 publications

References 36 publications

Univariate versus multivariate spectrophotometric data analysis of triamterene and xipamide; a quantitative and qualitative greenly profiled comparative study

Univariate versus multivariate spectrophotometric data analysis of triamterene and xipamide; a quantitative and qualitative greenly profiled comparative study

Stability-indicating capillary zone electrophoresis assay for the analysis of linezolid in tablets

Electroanalytical sensing of the antimicrobial drug linezolid utilising an electrochemical sensing platform based upon a multiwalled carbon nanotubes/bromocresol green modified carbon paste electrode

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