Two antiplatelet agents from

Teng, Che-Ming; Chen, Chien-Chih; Ko, Feng‐Nien; Lee, Lih-Gen; Huang, Tur-Fu; Chen, Yuh-Pan; Hsu, Hong‐Yuan

doi:10.1016/0049-3848(88)90336-2

Cited by 163 publications

(83 citation statements)

References 9 publications

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“…Magnolia compounds have been known for more than 20 years to interfere in some major pathways of platelet activation/inhibition: (1) TBXs, some of the most powerful agonists for platelet activation and major contributors to thrombus formation; TXB2, whether induced by collagen, arachidonic acid, or thrombin, is inhibited by magnolol and honokiol; also five aporphine alkaloids isolated from leaves of M. obovata, N-acetylanonaine, N-acetylxylopine, Nformylanonaine, liriodenine, and lanuginosine, show potent antiplatelet activities, probably by interfering with TXA2 production and/or binding (Teng et al, 1988;Pyo et al, 2003;Ho and Hong, 2012); (2) the activation of PPAR isoforms (α, β/δ, and γ), a pathway known to inhibit platelet aggregation; magnolol (20-60 μmol/L) dose-dependently enhances the activity and intracellular level of PPAR-β/γ in platelets (Shih and Chou, 2012); and (3) the cytosolic Ca 2+ influx and/or mobilization from intracellular stores that plays a crucial role in the platelet responses to various agonists (Lee et al, 2011); the rise of intracellular calcium caused by arachidonic acid or collagen is suppressed by both magnolol and honokiol (Teng et al, 1988;Pyo et al, 2003;Lee et al, 2011).…”

Section: Anti-platelet Activitymentioning

confidence: 99%

Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents

Poivre

Duez

2017

J. Zhejiang Univ. Sci. B

112

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Traditional Chinese herbal drugs have been used for thousands of years in Chinese pharmacopoeia. The bark of Magnolia officinalis Rehder & E. Wilson, known under the pinyin name "Houpo", has been traditionally used in Chinese and Japanese medicines for the treatment of anxiety, asthma, depression, gastrointestinal disorders, headache, and more. Moreover, Magnolia bark extract is a major constituent of currently marketed dietary supplements and cosmetic products. Much pharmacological activity has been reported for this herb and its major compounds, notably antioxidant, anti-inflammatory, antibiotic and antispasmodic effects. However, the mechanisms underlying this have not been elucidated and only a very few clinical trials have been published. In vitro and in vivo toxicity studies have also been published and indicate some intriguing features. The present review aims to summarize the literature on M. officinalis bark composition, utilisation, pharmacology, and safety.

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Section: Anti-platelet Activitymentioning

confidence: 99%

Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents

Poivre

Duez

2017

J. Zhejiang Univ. Sci. B

112

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“…1A) (1,2). HNK has long been known to have antithrombosis, antibacterial and anxiolytic effects (3)(4)(5)(6). However, its antitumor activities have only recently been described.…”

Section: Introductionmentioning

confidence: 99%

Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest

Wolf¹,

O’Kelly

Wakimoto

et al. 2007

Int J Oncol

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Abstract. Honokiol (HNK), a naturally occurring biphenyl, possesses potent antineoplastic and antiangiogenic properties. We investigated the in vitro and in vivo activity of HNK against breast cancer. HNK exhibited potent anti-proliferative activity against breast cancer cell lines and enhanced the activity of other drugs used for the treatment of breast cancer. In vivo, HNK was highly effective against breast cancer in nude mice. We identified two different effects of HNK on breast cancer cells: cell cycle inhibition, observed at lower doses of HNK, and induction of apoptosis, observed at higher doses of the compound. Our data suggest that HNK is a systemically available, non-toxic inhibitor of breast cancer growth and should be examined for clinical applications.

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“…It is widely used by Chinese people in treating thrombotic stroke, typhoid fever, anxiety and nervous disturbance [1] when used in combination with other herbs. With its major active constituent extracted from the bark of Houpu, honokiol has been found having a variety of pharmacological effects, such as anti-inflammatory [2] , antithrombotic [3] , anti-arrhythmic [4] , antioxidative [5] and anxiolytic effects [6] . Recently, honokiol has been reported to exhibit a potent cytotoxicity by inducing cell apoptosis in rat and human leukemia cells [7,8] , human fibrosarcoma cells [9] , human squamous lung cancer CH27 cells [10] and human SVR angiosarcoma cells [11] , yet there has been no report on honokiol in the treatment of human colorectal carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Honokiol: A potent chemotherapy candidate for human colorectal carcinoma

Chen

Wang²,

Wu³

et al. 2004

WJG

112

100

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AIM:To investigate the anticancer activity of Honokiol on RKO, a human colorectal carcinoma cell line in vitro and in vivo, and to evaluate its possible use in clinic. METHODS:In vitro anticancer activity of honokiol was demonstrated by its induction of apoptosis in tumor cells. We analyzed cell proliferation with MTT assay, cell cycle with flow cytosmeter, DNA fragment with electrophoresis on agarose gels. To test the mechanism of honokiol-induced apoptosis, Western blotting was used to investigate the factors involved in this process. The pharmacokinetics study of honokiol was tested by high phase liquid chromatography. In in vivo study, Balb/c nude mice were incubated with RKO cells. Honokiol was injected intraperitoneally every other day into tumor bearing Balb/c nude mice. RESULTS:Our results showed that honokiol induced apoptosis of RKO cells in a time-and dose-dependent manner. At 5-10 ug/mL for 48 h, honokiol induced apoptosis through activating Caspase cascades. Pharmacokinetics study demonstrated that, honokiol could be absorbed quickly by intraperitoneal injection, and maintained in plasma for more than 10 h. In nude mice bearing RKO-incubated tumor, honokiol displayed anticancer activity by inhibiting tumor growth and prolonging the lifespan of tumor bearing mice. CONCLUSION:With its few toxicity to normal cells and potent anticancer activity in vitro and in vivo, honokiol might be a potential chemotherapy candidate in treating human colorectal carcinoma.Chen F, Wang T, Wu YF, Gu Y, Xu XL, Zheng S, Hu X. Honokiol: A potent chemotherapy candidate for human colorectal carcinoma.

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Two antiplatelet agents from

Cited by 163 publications

References 9 publications

Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents

Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents

Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest

Honokiol: A potent chemotherapy candidate for human colorectal carcinoma

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