Two Bioactive Saponins from Albizia subdimidiata from the Suriname Rainforest

Abstract

Bioassay-guided fractionation of a methanol extract of Albizia subdimidiata using the engineered yeast strains 1138, 1140, 1353, and Sc7 of Saccharomyces cerevisiae as the bioassay tool resulted in the isolation of the two active saponins 1 and 2; one of these, albiziatrioside A (1), is described for the first time. The structures of 1 and 2 were established on the basis of HRMS, 1D and 2D NMR spectral data, and GC--MS analysis of the sugar units. Both isolated compounds showed significant cytotoxicity against the A2780 cell line.

In-Vivo Screening of Antiplasmodial Activity of Methanolic Leaf Extract of Albizia chevalieri against Plasmodium Berghei Model

“…The current finding was in agreement with studies done on medicinal plants used for malaria (Abdel-Kader et al,2001).…”

Triterpenoid saponins from Albizia lebbeck (L.) Benth and their inhibitory effect on the survival of high grade human brain tumor cells

“…6 Previous phytochemical studies of A. lebbeck stem bark reported the presence of glycosides of acacic acid lactones. 7 In the present investigation on A. lebbeck roots, we report the isolation and structural characterization of two new acacic acid glycosides, named lebbeckosides A-B (1)(2). The isolated compounds were evaluated for their inhibitory effect on the http://dx.doi.org/10.1016/j.carres.2014.12.004 0008-6215/Ó 2014 Elsevier Ltd. All rights reserved.…”

“…1 Triterpenoid saponins are commonly described in this genus. Adianthifoliosides, grandibracteosides, gummiferaosides, julibrosides, coriariosides, and albizosides are complex triterpenoid saponins isolated from the Albizia genus.…”

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“…Therefore, to overcome malaria, new knowledge, products and tools are urgently needed, especially new drugs [Abdel-Kader et al,2001]. The anti-malarial potential compounds derived from plants is proven by example such as quinine, obtained from cinchona species and artemisinins obtained from artemesia Species.…”