Two birds with one stone: innovative ceria-loaded gold@platinum nanospheres for photothermal-catalytic therapy of tumors

Tang, Minglu; Zhang, Zhaocong; Ding, Chengwen; Li, Jingqi; Shi, Yangtian; Sun, Tiedong; Chen, Chunxia

doi:10.1016/j.jcis.2022.07.065

Cited by 25 publications

(22 citation statements)

References 34 publications

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“…Au nanomaterials are common agents for photothermal therapy [43,44] . However, their low photothermal conversion efficiency in NIR range due to their small size hinders their application in photothermal therapy.…”

Section: Host-guest Interaction-induced Enhancement Of Photothermal C...mentioning

confidence: 99%

Host-guest assemblies for improved photothermal cancer therapy

Sun¹,

Ye²,

Zhou³

et al. 2023

Chem Synth

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Photothermal cancer therapy has attracted plenty of attention in the last decades due to its promising efficacy, spatiotemporal control, negligible drug resistance, etc. However, to achieve widespread clinical application, the enhancement of curative effect and the minimization of side effect still need be concerned about in the field of photothermal therapy. Host-guest assemblies, constructed by the inclusion of small molecular guests into macrocyclic hosts through non-covalent interactions, are featured with unique microenvironment and flexible, dynamic nature. On the basis of the abovementioned advantages, host-guest assemblies show great potential in photothermal therapy. However, to the best of our knowledge, the endeavors of host-guest assemblies-based photothermal therapy have not been systematically discussed. Hence, to benefit the design of advanced host-guest assembly-based photothermal agents and promote the development of photothermal therapy, in this review, the major achievements of host-guest assemblies in photothermal cancer therapy, including the enhancement of photothermal conversion efficiency, the improvement of targeted distribution in tumor site, and the superiority of constructing photothermal therapy-derived multimodal synergistic therapy, are discussed. In addition, the future perspectives on host-guest assemblies-based photothermal therapy are outlined.

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Section: Host-guest Interaction-induced Enhancement Of Photothermal C...mentioning

confidence: 99%

Host-guest assemblies for improved photothermal cancer therapy

Sun¹,

Ye²,

Zhou³

et al. 2023

Chem Synth

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“…Nanozyme materials have played a certain role in the lowtemperature photothermal precise treatment. The CeO 2 /Au@Pt nanospheres were fabricated by packing CeO 2 into core-shell Au@Pt and modifying the nanosphere surface with polyethylene glycol (PEG) (Tang et al, 2022). With catalytic-like and peroxidase-like dual enzymatic activities, CeO 2 is able to relive hypoxia and anti-tumor by generating toxic hydroxyl radicals.…”

Section: Photothermal Therapymentioning

confidence: 99%

Progress and perspectives of platinum nanozyme in cancer therapy

Wang

Liu

et al. 2022

Front. Chem.

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Malignant tumors, one of the worst-case scenarios within human health problems, are now posing an increasing threat to the well-being of the global population. At present, the treatment of malignant tumors mainly includes surgery, radiotherapy, chemotherapy, immunotherapy, etc. Radiotherapy and chemotherapy are often applied to inoperable tumors, and some other tumors after surgery as important adjuvant therapies. Nonetheless, both radiotherapy and chemotherapy have a series of side effects, such as radiation-induced lung injury, and chemotherapy-induced bone marrow suppression. In addition, the positioning accuracy of radiotherapy and chemotherapy is not assured and satisfactory, and the possibility of tumor cells not being sensitive to radiation and chemotherapy drugs is also problematic. Nanozymes are nanomaterials that display natural enzyme activities, and their applications to tumor therapy have made great progress recently. The most studied one, platinum nanozyme, has been shown to possess a significant correlation with radiotherapy sensitization of tumors as well as photodynamic therapy. However, there are still several issues that limited the usage of platinum-based nanozymes in vivo. In this review, we briefly summarize the representative studies regarding platinum nanozymes, and especially emphasize on the current challenges and the directions of future development for platinum nanozymes therapy.

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“…However, strict conditions such as oxygen leakage, acidic condition and overexpression of GSH in the tumor microenvironment (TME) constrain the photothermal conversion efficacy and ROS production of Phototherapies (Song et al, 2022). Photosensitive nanozymes which can remodel the restricted environment in tumor are intensively studied by scientists to achieve better phototherapeutic efficiency (Wang et al, 2022a;Tang et al, 2022).…”

Section: Nanozymes In Phototherapymentioning

confidence: 99%

Progress and prospects of nanozymes for enhanced antitumor therapy

Zhao

Yuan

et al. 2022

Front. Chem.

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Nanozymes are nanomaterials with mimicked enzymatic activity, whose catalytic activity can be designed by changing their physical parameters and chemical composition. With the development of biomedical and material science, artificially created nanozymes have high biocompatibility and can catalyze specific biochemical reactions under biological conditions, thus playing a vital role in regulating physiological activities. Under pathological conditions, natural enzymes are limited in their catalytic capacity by the varying reaction conditions. In contrast, compared to natural enzymes, nanozymes have advantages such as high stability, simplicity of modification, targeting ability, and versatility. As a result, the novel role of nanozymes in medicine, especially in tumor therapy, is gaining increasing attention. In this review, function and application of various nanozymes in the treatment of cancer are summarized. Future exploration paths of nanozymes in cancer therapies based on new insights arising from recent research are outlined.

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Two birds with one stone: innovative ceria-loaded gold@platinum nanospheres for photothermal-catalytic therapy of tumors

Cited by 25 publications

References 34 publications

Host-guest assemblies for improved photothermal cancer therapy

Host-guest assemblies for improved photothermal cancer therapy

Progress and perspectives of platinum nanozyme in cancer therapy

Progress and prospects of nanozymes for enhanced antitumor therapy

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