Two cases of adult t-cell leukemia associated with acute pancreatitis due to hypercalcemia

Dazai, Yasunobu; Katoh, Ichijiro; Hara, Yuji; Yoshida, Ryoichi; Kurihara, Kenji

doi:10.1016/0002-9343(91)80168-l

Cited by 14 publications

(4 citation statements)

References 11 publications

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“…ATL associated with hypercalcemia and acute pancreatitis was first described in 1984 by Hosokawa et al [43], followed later by other reports in 1990s [21, 44, 45]. Hypercalcemia is difficult to treat and can be the cause of death in ATL [46, 47].…”

Section: Acute Pancreatitis With Hypercalcemiamentioning

confidence: 99%

Pathogenesis of Metastatic Calcification and Acute Pancreatitis in Adult T-Cell Leukemia under Hypercalcemic State

Senba

Kawai²,

Mori

2012

Leukemia Research and Treatment

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Human T-cell leukemia virus type-1 (HTLV-1) is the causative agent of adult T-cell leukemia (ATL). Hypercalcemia is common in patients with ATL. These patients rarely develop metastatic calcification and acute pancreatitis. The underlying pathogenesis of this condition is osteoclast hyperactivity with associated overproduction of parathyroid hormone-related protein, which results in hypercalcemia in association with bone demineralization. The discovery of the osteoclast differentiation factor receptor activator of nuclear factor-κB ligand (RANKL), its receptor RANK, and its decoy receptor osteoprotegerin (OPG), enhanced our understanding of the mechanisms of ATL-associated hypercalcemia. Macrophage inflammatory protein-1-α, tumor necrosis factor-α, interleukin-1, and interleukin-6 are important molecules that enhance the migration and differentiation of osteoclasts and the associated enhanced production of RANKL for osteoblast formation. In this paper, we focus on metastatic calcification and acute pancreatitis in ATL, highlighting recent advances in the understanding of the molecular role of the RANKL/RANK/OPG system including its interaction with various cytokines and calciotropic hormones in the regulation of osteoclastogenesis for bone resorption in hypercalcemic ATL patients.

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Section: Acute Pancreatitis With Hypercalcemiamentioning

confidence: 99%

Pathogenesis of Metastatic Calcification and Acute Pancreatitis in Adult T-Cell Leukemia under Hypercalcemic State

Senba

Kawai²,

Mori

2012

Leukemia Research and Treatment

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“…Eleven cases of acute pancreatitis with leukemia, excluding cases of pancreatitis induced by chemotherapy, have been reported ( 7 - 16 ) ( Table ). The ages ranged from 11 years to 76 years, and six of the patients were male.…”

Section: Discussionmentioning

confidence: 99%

“…A bone marrow examination revealed increased monoblasts (38.6%) and eosinophils (8.1%), with 270,000 copies/μgRNA of the CBFβ/MYH11 fusion gene. On flow cytometry, monoblastic cells were positive for CD 13, 33, 34, and HLA-DR and negative for CD 2,3,4,5,7,8,10,19,20,16,56,14,and 41. A chromosomal analysis demonstrated 46,XY,inv(16)(p A C B 13.1q22) [13]/47,idem,+22 [5].…”

Section: Case Reportmentioning

confidence: 99%

Acute Myeloid Leukemia Developing with Acute Pancreatitis Mimicking Autoimmune Pancreatitis

et al. 2021

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A 33-year-old man was admitted to our hospital for fever and abdominal pain. A blood analysis revealed pancytopenia and increased serum pancreatic enzymes with disseminated intravascular coagulation. A detailed examination revealed acute pancreatitis, with diffuse swelling of the pancreas and diffuse beaded dilatation of the main pancreatic duct, which mimicked autoimmune pancreatitis complicated by acute myeloid leukemia. Systemic cytotoxic chemotherapy led to the remission of leukemia and pancreatitis. We hypothesized that the etiology of acute pancreatitis was invasion of leukemia cells. Acute pancreatitis is rare as a symptom of leukemia; however, we should consider the possibility of leukemia during the differential diagnosis of acute pancreatitis.

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“…Pancreatitis due to hypercalcemia secondary to hyperparathyroidism [1], adult T-cell leukemia (ATL) [2], multiple myeloma [3] or other malignant diseases is described [1]. Although renal cell carcinoma presenting as hypercalcemia has been described [4], there is no reported case of pancreatitis due to hypercalcemia in English literature.…”

Section: Introductionmentioning

confidence: 99%

Renal Cell Carcinoma Presenting as Acute Pancreatitis

Nabi¹,

Dogra²,

2002

Urol Int

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We present a 50-year-old male with renal cell carcinoma and hypercalcemia presenting as acute pancreatitis. The sudden onset of epigastralgia, acute pancreatitis and hypercalcemia with raised parathyroid-like peptide levels in this patient could not be explained except for renal cell carcinoma. This is the first report of such a complication in renal cell carcinoma. The rare presentation and management with a review of the literature is described.

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Two cases of adult t-cell leukemia associated with acute pancreatitis due to hypercalcemia

Cited by 14 publications

References 11 publications

Pathogenesis of Metastatic Calcification and Acute Pancreatitis in Adult T-Cell Leukemia under Hypercalcemic State

Pathogenesis of Metastatic Calcification and Acute Pancreatitis in Adult T-Cell Leukemia under Hypercalcemic State

Acute Myeloid Leukemia Developing with Acute Pancreatitis Mimicking Autoimmune Pancreatitis

Renal Cell Carcinoma Presenting as Acute Pancreatitis

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