Two cases of chronic myeloid leukemia in pediatric and young adolescent age group

Hossain, Mohammad Zaid; Hasan, Pratyay; Ahmed, Benozir; Mozazfia, Kazi Tuba E; Ferdush, Zannatul; Tasnim, Homyra; Khan, Sajid Ullah; Kair, Alamgir

doi:10.3329/jdmc.v25i1.33961

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…For patients without a suitable donor, control of the disease with chemotherapy is the best current alternative. 7,8 In a study from China by Cai Y et.al concluded the median age at diagnosis of CML in the pediatric population is 9-years. Most of all patients are CML-CP.…”

Section: Discussionmentioning

confidence: 99%

Chronic myeloid leukemia in childhood: a case report

Bhatta

Regmi

2021

J Pathol Nep

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Chronic myeloid leukemia is a rare hematological malignancy in the pediatric age group. It is a clonal hematopoietic stem cell disorder in which granulocytes are the major proliferative components with the presence of the BCR-ABL1 fusion gene. Here, we report a case of CML in a three - year child with a clinical presentation of fever and abdominal distension. The diagnosis was made based on bone marrow aspiration findings and molecular study.

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Section: Discussionmentioning

confidence: 99%

Chronic myeloid leukemia in childhood: a case report

Bhatta

Regmi

2021

J Pathol Nep

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“…Around 95% of children with CML are in the chronic phase (CML-CP). 1 , 4 , 11 CML is a type of MPN in which granulocytes are the primary proliferating cells. This proliferation causes neoplastic cells of the myeloid lineage to infiltrate the blood, bone marrow, spleen, and liver.…”

Section: Introductionmentioning

confidence: 99%

Sensorineural Hearing Loss in Juvenile CML: A Rare Case Report in Surabaya, Indonesia

Syamsuddin¹,

Notopuro²

2022

IMCRJ

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Chronic myeloid leukemia (CML) is a type of myeloproliferative neoplasm (MPN) in which granulocytes are the primary proliferating cells. CML in pediatric patients (juvenile CML) is an uncommon MPN, representing 2–3% of children newly diagnosed with leukemia. Sensorineural hearing loss that progresses rapidly is an uncommon early sign of a hematological disorder in patients with CML. This article presents the case of a 10-year-old patient with complaints of bilateral hearing loss for 2 weeks. Pure-tone audiometry indicated sensorineural hearing loss of the left ear and mixed hearing loss of the right ear. After an in-depth evaluation of a bone marrow smear and positivity for the BCR-ABL fusion gene, it was concluded that the patient had chronic-phase juvenile CML. However, hearing loss recovery after hydroxyurea therapy could not be observed because the patient died after suffering an uncontrolled seizure on day 14 of hospitalization.

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Juvenile chronic myeloid leukemia: a case report

Pandey,

Singh,

Srivastava

et al. 2024

Int J Res Med Sci

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Chronic myeloid leukemia (CML) accounts for 2-3% of leukemias in children under 15 and 9% in adolescents aged 15-19. The diagnosis of CML in children, adolescents, and young adults has several differences compared to that in adults. Juvenile myelomonocytic leukemia (JMML)/ juvenile CML is a rare, malignant myelodysplastic/ myeloproliferative neoplasm (MPN) overlap haemopoetic disorder that presents in infants and toddlers and it must be differentiated from other disorders that can show similar presentation in this age group. JMML is very uncommon and the diagnosis is often difficult to establish. The disease has a rapid course and has a median survival of less than 10 months when untreated or undertreated. In this case report we present a case of a 7-year-old male patient with gingival enlargement and swelling along with mobility of mandibular anterior teeth with various associated systemic factors in which various hematological, biochemical, and radiographic investigations were carried out to differentiate CML from other systemic conditions.

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Two cases of chronic myeloid leukemia in pediatric and young adolescent age group

Abstract: The incidence of chronic myeloid leukemia (CML) is 1-2 cases

Cited by 5 publications

References 9 publications

Chronic myeloid leukemia in childhood: a case report

Chronic myeloid leukemia in childhood: a case report

Sensorineural Hearing Loss in Juvenile CML: A Rare Case Report in Surabaya, Indonesia

Juvenile chronic myeloid leukemia: a case report

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