Two cases of diabetic mastopathy: MR imaging and pathological correlation

Nasu, Hatsuko; Ikeda, Akiko; Ogura, Hironao; Teruya, C.; Koizumi, Kei; Kinoshita, Mana; Tsuchida, Takashi; Baba, Satoshi; Miura, Katsutoshi; Takehara, Yasuo; Sakahara, Harumi

doi:10.1007/s12282-012-0407-5

Cited by 12 publications

(10 citation statements)

References 14 publications

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“…[13] However, the mass may have a hypersignal diffusion which does not allow to immediately exclude a malignant process. [14] After injection of contrast agent, we have demonstrated in our case a gradual enhancement in favor of benignity with a type I enhancement curve also reported by Sakuhara et al, [15] tunckbilec [16] and costantini. [13] However, diabetic mastopathy may have all malignancy criteria at MRI, i.e., hypersignal diffusion with a decrease in ADC coefficient and massive and early enhancement with a type III enhancement curve.…”

Section: Discussionsupporting

confidence: 87%

Imaging finding in diabetic mastopathy: A case report

Bile

Antoun

Ahoury

et al. 2018

IJDI

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Diabetic mastopathy is an uncommon immunologic breast disease occurring usually in patients under long-term insulin treatment. It can pose a question of differential diagnosis with breast cancer especially in case of family history of breast cancer. We report the radiological diagnostic approach of a case of diabetic mastopathy with family history of breast cancer. The mammogram was nonspecific. Ultrasound showed two suspicious masses of right breast without suspicious enhancement on MRI. Diabetic mastopathy was confirmed on histology without cancer cells. Diabetic mastopathy is a diagnostic challenge and needs to be suspected in all patients with type I diabetes. Image-guided biopsy confirmation remains mandatory. The literature is briefly reviewed.

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Section: Discussionsupporting

confidence: 87%

Imaging finding in diabetic mastopathy: A case report

Bile

Antoun

Ahoury

et al. 2018

IJDI

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“…In the magnetic resonance spectrum, the choline peak was absent in the type 1 imaging uptake curve and the proton spectrum. Despite the improvement of imaging techniques, there are still great challenges in the diagnosis of diabetic breast disease[ 9 , 21 - 23 ]. An increasing number of studies have reported cases of diabetic breast disease complicated with malignant tumors[ 24 , 25 ], and some studies[ 26 , 27 ] have also shown that neither clinical examination nor imaging studies can clearly distinguish diabetic breast disease from breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Diabetic mastopathy in an elderly woman misdiagnosed as breast cancer: A case report and review of the literature

Chen

Shijun

2021

WJCC

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BACKGROUND Diabetic mastopathy is a rare benign disease in clinical practice that mainly occurs in young and middle-aged women with type 1 diabetes. It has also been reported that this disease can be found in patients with type 2 diabetes and other autoimmune diseases, such as Hashimoto's thyroiditis, as well as in men. The pathogenesis of diabetic mastopathy is not yet clear, and it is easily confused with breast cancer due to their similar clinical manifestations and imaging features. CASE SUMMARY A 69-year-old female patient was admitted because of painless breast masses, with a history of type 2 diabetes. The imaging and physical examination suggested a high risk of breast cancer. Further histopathological analysis showed dense lymphocytes infiltrating around the lobules of the breast, and extensive fibrosis of the surrounding stroma. Finally, diabetic mastopathy was diagnosed. CONCLUSION The diagnosis of diabetic mastopathy in elderly patients with painless breast masses is difficult to distinguish from breast cancer, and its imaging manifestations are not specific.

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“…These results are also in agreement with those of other studies, which report cases of dense breasts without findings or unspecific findings such as focal asymmetry, not suspected in isolation. 2,7,11,20,23,24 MRI features have been scarcely reported in SLL, usually in scattered case reports. MRI is not always useful for differentiating SLL from cancer, as both may present overlapping findings.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound as a Valuable Imaging Modality in Sclerosing Lymphocytic Lobulitis: Imaging Features Based on a Retrospective Cohort Analysis of 51 Cases

et al. 2021

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Purpose: Sclerosing lymphocytic lobulitis (SLL) is a rare benign breast condition usually associated with diabetes mellitus and whose imaging features have been assessed in few studies, limiting the adoption of diagnostic guidelines. We aimed to identify the main morphological features associated with SLL on imaging examinations (mainly ultrasound and mammography) and to retrospectively evaluate the role that each method played in the diagnostic workup (detection and indication for biopsy). Methods: A retrospective study was conducted in a high-volume single center, encompassing 51 consecutive patients (100% female; 26-78 y; 43.7 ± 15.5 y) with histopathologically proven SLL (59 lesions; 0.5-6.1 cm). Results: Most lesions (31/59; 53%) were found in asymptomatic individuals. Ultrasound detected 91.1% (51 out of 56 lesions assessed by this modality), of which 94.1% were non-circumscribed masses (BI-RADS® 4). Mammography detected 41.6% (15 out of 36 lesions assessed by this modality), with a predominance (80%) of non-calcified ones (masses, asymmetries and distortion). Two-year follow-up was achieved in 29 lesions (49%), showing complete remission (45%) or stability (41%) in most cases. Conclusions: Most lesions in this retrospective sample have been detected by means of ultrasound and had their need for biopsy indicated by this modality. Female diabetic patients younger than 40 years presenting with a palpable lesion and a non-circumscribed mass on ultrasound could be submitted to core biopsy; histopathologic findings suggestive of SLL should be considered concordant in this scenario, with subsequent conservative treatment.

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Two cases of diabetic mastopathy: MR imaging and pathological correlation

Cited by 12 publications

References 14 publications

Imaging finding in diabetic mastopathy: A case report

Imaging finding in diabetic mastopathy: A case report

Diabetic mastopathy in an elderly woman misdiagnosed as breast cancer: A case report and review of the literature

Ultrasound as a Valuable Imaging Modality in Sclerosing Lymphocytic Lobulitis: Imaging Features Based on a Retrospective Cohort Analysis of 51 Cases

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