Two Cases of Equine Abortion Caused by <i>Rhodococcus equi</i>

Szeredi, Levente; Molnár, Tamás; Glávits, Róbert; Takaı̈, Shinji; Makrai, László; Jankovics, I.; Piero, Fábio Del

doi:10.1354/vp.43-2-208

Cited by 18 publications

(15 citation statements)

References 13 publications

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“…Pyogranulomatous inflammation with multinucleated Langhans' giant cells in the lungs was found to be the most prominent fetal lesion in this case. This picture is rather similar to that seen in cases of equine abortions induced by Cellulosimicrobium cellulans, H. capsulatum and Rhodococcus equi (Rezabek et al, 1993;Bolin et al, 2004;Szeredi et al, 2006). Although in three cases no bacteria could be cultured, a bacterium-induced abortion was diagnosed because of the clear evidence of bacteria in the tissue lesions.…”

Section: Discussionsupporting

confidence: 73%

A survey of equine abortion and perinatal foal losses in Hungary during a three-year period (1998–2000)

Szeredi

Tenk

Jánosi

et al. 2008

Acta Veterinaria Hungarica

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Cases of equine abortion and perinatal foal losses were investigated in Hungary during a three-year period (1998)(1999)(2000). Samples from aborted equine fetuses and newborn foals (total n = 96) were examined using bacteriological, virological, pathological, immunohistochemical (IHC), molecular biological and serological methods. The cause of abortion and perinatal foal loss was identified in 67/96 cases (70%); viral infection was found in 22 (23%), viral and bacterial coinfection in 1 (1%), bacterial infection in 23 (24%), protozoan infection in 1 (1%) and fungal infection in 2 cases (2%). Morphological lesions suggestive of infection were recorded in 2 (2%) and non-infectious causes in 16 cases (17%).

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Section: Discussionsupporting

confidence: 73%

A survey of equine abortion and perinatal foal losses in Hungary during a three-year period (1998–2000)

Szeredi

Tenk

Jánosi

et al. 2008

Acta Veterinaria Hungarica

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“…The microscopic appearance of lungs seemed as in previous reports (6,11,20,21). In mediastinal lymph nodes, inflammatory cell infiltration and necrosis of lymphoid follicles were also observed similarly to the previous reports (8,14).…”

Section: Discussionsupporting

confidence: 87%

“…R. equi has been detected by immunohistochemical methods, using polyclonal and monoclonal antibodies in formalin-fixed and parafin-embedded sections. R. equi antigens were demonstrated with immunoperoxidase technique usually in cytoplasm of macrophages and rarely in cytoplasm neutrophils and giant cells at lung and mediastinal lymph node sections (8,13,14,20,21,26). In the present study the R. equi antigens were located in the center of suppurative inflammation, in the bronchiole lumina, and in the cytoplasm of macrophages and rarely neutrophils.…”

Section: Discussionmentioning

confidence: 99%

The pathological findings of Rhodococcus equi infection and its diagnosis with immunoperoxidase technique in foals

;HAZIROĞLU¹

2009

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Summary:Twelve foals with difficulty in respiration that have died during spring-summer months between 2003-2006 years were necropsied. On necropsy, pneumonia was detected in all of the foals. In 5 animals, caseo-necrotic nodules were seen in the lungs. In histopathological examination, purulent bronchopneumonia was noticed. In immunohistochemical staining, Rhodococus equi antigens were determined in the cytoplasm of macrophages and occasionally in neutrophils in lungs and mediastinal lymph nodes by immunoperoxidase technique. No lesions were detected in the intestines confirming that this form of infection is rare compared to the lung form. In the present study, R. equi was microbiologically isolated only in two cases. In conclusion, R. equi infection was diagnosed in all of the twelve cases, and estimated to be the reason of pneumonia in the foals. It was also shown that immunoperoxidase technique can be successfully used for R. equi infection in the field.

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“…122 The spleen emerges as an important hematopoietic organ in human, bovine, and likely equine fetuses in mid-to late gestation and contributes somewhat less in dogs and cats. 35,69,92,107 In neonatal mice, humans, dogs, cats, cattle, and pigs, persistent residual sites of fetal hematopoiesis are retained-mainly in spleen but also in liver and lymph nodes-that regress with growth and disappear prior to adulthood. 45,78,108,113 In mice (and, to a lesser extent, rats and hamsters), the spleen continues to play an active role in hematopoiesis throughout adulthood.…”

Section: Embryonic and Fetal Blood Cell Production: Differentiation Omentioning

confidence: 99%

Extramedullary Hematopoiesis: A New Look at the Underlying Stem Cell Niche, Theories of Development, and Occurrence in Animals

2012

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Extramedullary hematopoiesis (EMH) is the formation and development of blood cells outside the medullary spaces of the bone marrow. Although widely considered an epiphenomenon, secondary to underlying primary disease and lacking serious clinical or diagnostic implications, the presence of EMH is far from incidental on a molecular basis; rather, it reflects a well-choreographed suite of changes involving stem cells and their microenvironment (the stem cell niche). The goals of this review are to reconsider the molecular basis of EMH based on current knowledge of stem cell niches and to examine its role in the pathophysiologic mechanisms of EMH in animals. The ability of blood cells to home, proliferate, and mature in extramedullary tissues of adult animals reflects embryonic patterns of hematopoiesis and establishment or reactivation of a stem cell niche. This involves pathophysiologic alterations in hematopoietic stem cells, extracellular matrix, stromal cells, and local and systemic chemokines. Four major theories involving changes in stem cells and/or their microenvironment can explain the development of most occurrences of EMH: (1) severe bone marrow failure; (2) myelostimulation; (3) tissue inflammation, injury, and repair; and (4) abnormal chemokine production. EMH has also been reported within many types of neoplasms. Understanding the concepts and factors involved in stem cell niches enhances our understanding of the occurrence of EMH in animals and its relationship to underlying disease. In turn, a better understanding of the prevalence and distribution of EMH in animals and its molecular basis could further inform our understanding of the hematopoietic stem cell niche.

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Two Cases of Equine Abortion Caused by Rhodococcus equi

Cited by 18 publications

References 13 publications

A survey of equine abortion and perinatal foal losses in Hungary during a three-year period (1998–2000)

A survey of equine abortion and perinatal foal losses in Hungary during a three-year period (1998–2000)

The pathological findings of Rhodococcus equi infection and its diagnosis with immunoperoxidase technique in foals

Extramedullary Hematopoiesis: A New Look at the Underlying Stem Cell Niche, Theories of Development, and Occurrence in Animals

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