Two cases of Guillain-Barré syndrome after cerebral hemorrhage or head trauma

Jia, Hongyan; Tian, Ye; Wu, Yan-Min; Li, Bin

doi:10.20517/2347-8659.2016.51

Cited by 11 publications

(5 citation statements)

References 13 publications

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“…In summary, the implementation of cinepazide maleate-combined routine treatment after surgery has a positive effect on patients with severe cerebral hemorrhage, which can improve the cerebral blood flow, promote microcirculation, and have good anti-inflammatory effect, thereby reducing cerebral damage. Jia et al [ 25 ] believed that cinepazide maleate had the effect of reducing serum inflammatory factor levels and blood viscosity and had a good clinical therapeutic effect on cerebral hemorrhage, which is consistent with the results of this study. The study has some shortcomings.…”

Section: Discussionsupporting

confidence: 91%

Effect of Cinepazide Maleate on Serum Inflammatory Factors of ICU Patients with Severe Cerebral Hemorrhage after Surgery

Zhang

Xia

Shang³

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore the effect of cinepazide maleate on serum inflammatory factors of intensive care unit (ICU) patients with severe cerebral hemorrhage after surgery. Methods. 116 ICU patients with severe cerebral hemorrhage treated in Taian Maternal and Child Health Hospital from June 2018 to June 2020 were selected as the research objects and randomly divided into the control group and experimental group, with 58 patients in each group. The control group was given routine treatment, while the experimental group was additionally given an intravenous drip of cinepazide maleate to compare the clinical efficacy and serum inflammatory factors between the two groups. Results. The total effective rate in the experimental group was higher than that in the control group ( P < 0.05 ). After treatment, the Glasgow Coma Scale (GCS), National Institutes of Health Stroke Scale (NIHSS), and Fugl-Meyer scores in both groups were better than those before treatment, and the scores in the experimental group were better than those in the control group ( P < 0.05 ). The oxidative stress indexes such as total antioxidant capacity (T-Aoc), superoxide dismutase (SOD), and glutathione peroxidase (GSH-PX) in the experimental group were higher than those in the control group, while malondialdehyde (MDA) in the experimental group was lower than that in the control group ( P < 0.05 ). The high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-α (TNF-α) levels in the experimental group were lower than those in the control group ( P < 0.05 ). Compared with the control group, the cerebrovascular function in the experimental group was significantly improved ( P < 0.05 ), with statistically significant differences. Conclusion. Cinepazide maleate can effectively reduce the serum inflammatory factor levels of ICU patients with severe cerebral hemorrhage after surgery, alleviate the oxidative stress response in the body, and improve the cerebrovascular function and cerebral nerve function, which is worthy of clinical promotion.

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Section: Discussionsupporting

confidence: 91%

Effect of Cinepazide Maleate on Serum Inflammatory Factors of ICU Patients with Severe Cerebral Hemorrhage after Surgery

Zhang

Xia

Shang³

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…T-lymphocytes and macrophages accumulate and induce the transformation of microglial cells into antigen-presenting cells. As such, myelin-associated proteins released from neuronal debris are presented to the immune system, and anti-myelin antibodies are formed, precipitating GBS [6,8].…”

Section: Discussionmentioning

confidence: 99%

A Case Report: Rare Presentation of Intracranial Hemorrhage post Guillain Barré Syndrome

Halabi¹,

Shami²,

Hijazi³

et al. 2020

Int J Clin Res

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Background: Guillain Barre Syndrome (GBS) is an autoimmune disease where antibodies attack the myelin sheath of peripheral nerves. The hallmark of the disease includes symmetrical quadriparesis, respiratory distress, and failure with subsequent need for mechanical ventilation. Most cases occur after a viral or bacterial infection. Other causes, such as intracranial hemorrhage, also exist, and several case studies report an association between these two pathologies. Case Report: In this report, we present the case of an elderly male patient with intracranial (IC) bleeding post-GBS. The patient was admitted to the hospital for dyspnea and diagnosed with pneumonia. When he started complaining of progressive bilateral ascending paralysis of his lower extremities, we performed a lumbar puncture, and he was diagnosed with GBS. We started him on intravenous immune globulins (IVIGs) immediately, but his weakness progressed to include his respiratory muscles, and he required mechanical ventilatory support with Intensive Care Unit (ICU) admission. We extubated him after two weeks, but he needed to be reintubated 24 hours later for a severely decreased level of consciousness. An urgent computed tomography scan of the brain showed IC bleeding. The patient developed a septic shock due to his pneumonia, which was refractory to antibiotics and vasopressors. He passed away a few weeks after that. Conclusion: Our case represents a unique type of association between IC hemorrhages and GBS, where the bleeding occurred several days after, as opposed to before GBS. It also reinforces the correlation between GBS and Intracranial bleeding and stresses the importance of having a high index of suspicion when facing either pathology since both have similar symptoms that may overlap or mask each other.

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“…There have been several case reports of GBS after head trauma. 26 – 30) One retrospective study showed that 2% of GBS cases were triggered by trauma. 24) An association with the administration of a tetanus vaccination is reported.…”

Section: Discussionmentioning

confidence: 99%

“… 42) Peripheral circulation of those activated T- and B-cells through disrupted BBB might cause demyelinating diseases or axonal damage in the peripheral nervous system. 30) Based on the foregoing discussion, it may be assumed that the traumatic brain injury caused the disruption of BBB followed by inflammation inside the CNS, resulting in PRES and GBS.…”

Section: Discussionmentioning

confidence: 99%

Posterior Reversible Encephalopathy Syndrome and Guillain-Barré Syndrome after Head Injury: Case Report

Yonekura

Anno

Kobayashi

2018

Neurol. Med. Chir.(Tokyo)

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We report a case of head injury with posterior reversible encephalopathy syndrome (PRES), followed by Guillain-Barré syndrome (GBS). A 74-year-old man was brought to our hospital after a fall. Computed tomography revealed intracranial hemorrhage. Magnetic resonance imaging showed bilateral reversible intensities with features of vasogenic edema in parietooccipital areas, suggesting PRES. After admission, weakness and areflexia of extremities and respiratory muscles developed gradually, which favored a diagnosis of GBS. Common etiologies of PRES were absent. Concurrent occurrence of PRES and GBS is rare. Given that PRES can be an initial manifestation of GBS, GBS must be considered in head trauma patients with PRES.

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Two cases of Guillain-Barré syndrome after cerebral hemorrhage or head trauma

Cited by 11 publications

References 13 publications

Effect of Cinepazide Maleate on Serum Inflammatory Factors of ICU Patients with Severe Cerebral Hemorrhage after Surgery

Effect of Cinepazide Maleate on Serum Inflammatory Factors of ICU Patients with Severe Cerebral Hemorrhage after Surgery

A Case Report: Rare Presentation of Intracranial Hemorrhage post Guillain Barré Syndrome

Posterior Reversible Encephalopathy Syndrome and Guillain-Barré Syndrome after Head Injury: Case Report

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