Two Cases of Infantile Intra-abdominal Inflammatory Myofibroblastic Tumor

Kim, Soo-Hong; Cho, Yong-Hoon; Kim, Hae Young

doi:10.5223/pghn.2014.17.2.116

Cited by 7 publications

(5 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Calcification was observed in some cases with necrosis in the center. [ 23 , 24 ] Like previous reports, in our case, the ultrasound showed a solid, medium-low echogenic mass and the right ureter upper-middle section was not completely obstructed due to the hydronephrosis. By CT scan, the tumor showed significant enhancement with a clear boundary, homogeneous density, and flecks like calcification.…”

Section: Discussionsupporting

confidence: 81%

Inflammatory myofibroblastic tumor of kidney together with ipsilateral perinephric and periureteric fibrosis

Sun

Wang²,

Guo³

et al. 2017

Medicine

View full text Add to dashboard Cite

Rationale:Both inflammatory myofibroblastic tumor (IMT) and retroperitoneal fibrosis are rare lesions, but kidney involvement is more rare. It is the first study about IMT of the kidney in a patient with perinephric and periureteric fibrosis and we hold that fibroblast proliferation may be an intermediate status in oncogenesis of IMT. But further investigation is necessary in order to better clarify the relationship between fibroblast proliferation and IMT.Patient concerns:A 54-year-old female presented no positive signs except dull back pain after overwork.Diagnoses:On the basis of the urinary ultrasonography and computed tomography (CT) scan, we strongly suspected a renal cell carcinoma.Interventions:Considering the little remaining function of the right kidney and the possibility of malignancy, we performed a laparoscopic right radical nephrectomy.Outcomes:According to the analysis of the postoperative paraffin section and immunohistochemistry assay, a final diagnosis of IMT and retroperitoneal fibrosis nodules was made.Lessons:Both IMTs are rare lesions and its etiology and pathogeny are unclear. It is the first study about IMT of the kidney in a patient with perinephric and periureteric fibrosis. This report suggested that fibroblast proliferation may be an intermediate status in oncogenesis of IMT, but further investigation is necessary in order to better clarify the relationship between fibroblast proliferation and IMT. The preoperative diagnosis of renal IMT remains difficult. Preoperative fine-needle aspiration or percutaneous biopsy and intraoperative frozen section were applied to confirm the diagnosis to avoid unnecessary nephrectomy, especially in patients with renal insufficiency, bilateral masses, or a solitary kidney.

show abstract

Section: Discussionsupporting

confidence: 81%

Inflammatory myofibroblastic tumor of kidney together with ipsilateral perinephric and periureteric fibrosis

Sun

Wang²,

Guo³

et al. 2017

Medicine

View full text Add to dashboard Cite

show abstract

“…The lung is the most common site of IMT ( 15 ). In addition, IMTs originating from female genital organs ( 4 , 16 ), the intra-abdominal region ( 17 , 18 ), the retroperitoneum ( 19 ), the ileocecal mesentery ( 20 ) and the pancreas ( 21 ) have also been reported. However, those located in the liver are even rarer ( 5 ).…”

Section: Discussionmentioning

confidence: 99%

A unique case of inflammatory myofibroblastic tumor of the liver manifesting with biloma: A case report

Huang

Zhao

et al. 2022

Oncol Lett

View full text Add to dashboard Cite

Anaplastic lymphoma kinase (ALK)-negative hepatic inflammatory myofibroblastic tumors (IMTs) harboring the ETS variant transcription factor 6-neurotrophic receptor tyrosine kinase 3 ( ETV6-NTRK3 ) fusion gene and manifesting with biloma are extremely rare, and their biological behavior is unclear. The present study reports the case of a 45-year-old female with ALK-negative IMT of the liver harboring the ETV6-NTRK3 fusion gene and manifesting with biloma. Computed tomography of the abdomen confirmed the lesions to be a low-density mass, measuring 11.2×8.5×10.5 cm, located in the left lobe of the liver, and a lower-density mass, measuring 8.5×6.1×5.9 cm, located in the interior of the tumor. As the suspicion of a malignancy remained high, surgical resection of the left hepatic lobe, including the tumor, was undertaken. Intraoperatively, a tumor (12×10×9 cm), with an unclear boundary, incomplete capsule and fish-like texture, was found in the left lateral lobe of the liver, and a biloma, measuring 8×6 cm, was identified inside the tumor. Pathological examination revealed spindle cell proliferation with infiltration of chronic inflammatory cells and mucinous degeneration. Immunohistochemical studies showed negativity for ALK, CD117, CD34, discovered on GIST-1, desmin, smooth muscle actin, S-100, CD21, pan-cytokeratin, epithelial membrane antigen, CD23 and CD35, but positivity for vimentin staining, and 5% Ki-67-positive cells. Fluorescence in situ hybridization studies assessing characteristic genetic rearrangements using ALK, RET, ROS1, MDM2, MGEA5 and ETV6 break-apart assays, revealed the presence of the ETV6-NTRK3 fusion oncogene and negativity for ALK, RET, ROS1, MDM2 and MGEA5 . The patient was discharged 7 days post-operatively, without any adjuvant treatment. No recurrence of symptoms was noted at the 3-year follow-up. To the best of our knowledge, this is the first report of biloma in an ALK-negative IMT of the liver, which may increase our understanding of hepatic IMT.

show abstract

“…The imaging findings of IMT in the mesentery or omentum have been reported and mostly occur in children or teenager. 21 – 23 A large well-defined or ill-defined mass can be observed; the lesion infiltrates peripherally and involves the adjacent intestinal tube. 21 – 23 Calcification can be observed in some cases with necrosis in the center.…”

Section: Discussionmentioning

confidence: 99%

“… 21 – 23 A large well-defined or ill-defined mass can be observed; the lesion infiltrates peripherally and involves the adjacent intestinal tube. 21 – 23 Calcification can be observed in some cases with necrosis in the center. 21 – 23 Enhancement scanning shows varied enhancement methods of IMT in the mesentery or omentum, such as low enhancement, heterogeneous enhancement, or edge enhancement.…”

Section: Discussionmentioning

confidence: 99%

“… 21 – 23 Calcification can be observed in some cases with necrosis in the center. 21 – 23 Enhancement scanning shows varied enhancement methods of IMT in the mesentery or omentum, such as low enhancement, heterogeneous enhancement, or edge enhancement. 21 – 22 Only individual cases of the imaging findings of EIMS in the abdominal cavity have been reported.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Incomplete Intestinal Obstruction Caused by a Rare Epithelioid Inflammatory Myofibroblastic Sarcoma of the Colon

et al. 2015

View full text Add to dashboard Cite

We reported on 1 case of epithelioid inflammatory myofibroblastic sarcoma (EIMS) that occurred in the colon and resulted in an incomplete intestinal obstruction.A 65-year-old male patient presented with abdominal pain without any obvious predisposing cause. He reported a paroxysmal dull pain. Hematochezia occurred occasionally. The symptoms appeared repeatedly and became progressively more aggravated. The patient sought medical advice in our hospital, and his enteroscopy showed colon tumors and an incomplete colonic obstruction. The laboratory examination indicated mild anemia. Plain and enhanced computed tomography (CT) scans showed a large, dumbbell-shaped, soft-tissue mass of 4.1 cm × 9.3 cm in the curved lumen of the descending colon near the spleen. After enhancement, the lesion presented with progressive and uneven enhancement. The boundary between the lesion and parts of the left kidney and spleen was obscured. A small amount of exudation was observed around the lumen, and a slightly enlarged lymph node shadow was observed in the mesangial gap.After each preoperative examination was completed, the tumors invading the spleen and left kidney were excised. Based on the surgical specimen pathological histology and immunohistochemistry, epithelioid inflammatory myofibroblastic sarcoma was diagnosed. Tumor recurrence occurred a short time after excision.EIMS in the abdominal cavity could occur on the intestinal wall, occasionally manifesting as large masses that expand to the inside and the outside of the cavity. It needs to be distinguished from other tumors. Tumor recurrence can easily occur after surgery. Anaplasticlymphoma kinase (ALK) inhibitors are a potential alternative treatment option.

show abstract

Two Cases of Infantile Intra-abdominal Inflammatory Myofibroblastic Tumor

Cited by 7 publications

References 11 publications

Inflammatory myofibroblastic tumor of kidney together with ipsilateral perinephric and periureteric fibrosis

Inflammatory myofibroblastic tumor of kidney together with ipsilateral perinephric and periureteric fibrosis

A unique case of inflammatory myofibroblastic tumor of the liver manifesting with biloma: A case report

Incomplete Intestinal Obstruction Caused by a Rare Epithelioid Inflammatory Myofibroblastic Sarcoma of the Colon

Contact Info

Product

Resources

About