Two Cases of Lacaziosis in Bottlenose Dolphins (<i>Tursiops truncatus</i>) in Japan

Sano, Ayako; Yamate, Jyoji; Nakagawa, Eiko; Kuwamura, Mitsuru; Izawa, Takeshi; Tanaka, Miyuu; Hasegawa, Yūko; Chibana, Hiroji; Izumisawa, Yasuharu; Miyahara, Hirokazu; Uchida, Senzo

doi:10.1155/2013/318548

Cited by 28 publications

(42 citation statements)

References 26 publications

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“…However, their DNA sequences are not available. More recently, 3 groups in Japan ( 14 , 15 ) and Spain ( 16 ), who also used molecular methods, reported similar observations for several dolphin species including, T. truncatus and Lagenorhynchus obliquidens , which had skin granulomas and yeast-like cells in infected tissues. These studies showed that glycoprotein 43 ( gp43 )–like and ITS partial DNA sequences isolated from infected dolphins placed the etiologic agent of skin granulomas among human P. brasiliensis strains.…”

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confidence: 64%

“…We analyzed DNA sequences of pathogens isolated from 6 dolphins with lacaziosis/lobomycosis captured in the Indian River Lagoon. Diverse geographic locations of dolphins in the Atlantic Ocean ( 13 , 16 ) and the Pacific Ocean ( 14 , 15 ) and specimens evaluated by molecular methods provide additional support for placement of the etiologic agent of keloidal-like granulomas in dolphins within P. brasiliensis (Figure 3). Because these geographic locations, especially for cases from Japan ( 14 , 15 ), have different ecologic niches than locations for P. brasiliensis in South America ( 4 ), detection of dolphins infected with an uncultivated P. brasiliensis type in these ecosystems is a major finding.…”

Section: Discussionmentioning

confidence: 94%

“…AB811031) ( 14 ) and Ueda et al (GenBank accession no. LC067206) ( 15 ) and ITS DNA sequences reported by Esperón et al (GenBank accession no. HQ413323) ( 16 ) for phylogenetic analysis of several homologous DNA sequences of P. brasiliensis , P. lutzii , and L. loboi in GenBank.…”

Section: Methodsmentioning

confidence: 99%

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Cutaneous Granulomas in Dolphins Caused by Novel UncultivatedParacoccidioides brasiliensis

Vilela¹,

Bossart²,

Leger³

et al. 2016

Emerg. Infect. Dis.

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confidence: 64%

Section: Discussionmentioning

confidence: 94%

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Cutaneous Granulomas in Dolphins Caused by Novel UncultivatedParacoccidioides brasiliensis

Vilela¹,

Bossart²,

Leger³

et al. 2016

Emerg. Infect. Dis.

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“…Characterized by greyish, whitish to slightly pink, verrucous lesions, often in pronounced relief, that may ulcerate and form plaques, lobomycosis 2 and LLD naturally affect common bottlenose dolphins Tursiops truncatus and Guiana dolphins Sotalia guianensis from Brazil, Ecuador, Peru, Colombia, Venezuela and Suriname (de Vries and Laarman, 1973;Simões-Lopes et al, 1993;Van Bressem et al, 2007;Bermudez et al, 2009;Daura-Jorge and Simões-Lopes, 2011). Lobomycosis is caused by a dimorphic fungus resembling Lacazia loboi (Taborda et al, 1999;Hauboldt et al, 2000) but genetically more closely related to Paracoccidioides brasiliensis (order Onygenales, family Ajellomycetaceae) (Rotstein et al, 2009;Esperon et al, 2011;Ueda et al, 2013). LLD is 1 Moreno, I.B., Ott, P.H., Tavares, M., Oliveira, L.R., Borba, M.R., Driemeier, D., Nakashima, S.B., Heinzelmann, L.S., Siciliano, S. and Van Bressem, M-F. (2008) Mycotic dermatitis in common bottlenose dolphins (Tursiops truncatus) from southern Brazil, with a confirmed record of lobomycosis disease.…”

Section: Introductionmentioning

confidence: 99%

Epidemiological characteristics of skin disorders in cetaceans from South American waters

Bressem

Flach²,

Reyes³

et al. 2015

Lat. Am. J. Aquat. Mamm.

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Abstract. We document the macroscopic phenotypic characteristics (relative size, location, pattern, colour, extension), prevalence and evolution of five types of skin disorders of unknown aetiology, including 'green-brown plaques' (GBP), 'orange patches' (OPA), 'cutaneous nodules' (NOD), 'pale dermatitis' (PAD) and 'expansive annular lesions' (EAL) in five odontocete species (n = 559 individuals) from the Southeast Pacific (n = 230) and Southwest Atlantic (n = 329) Oceans. GBP affected two likely-adult Sotalia guianensis traveling side-by-side in a freshwater area of the Cananéia Estuary in August 2009. Low salinity is suggested as predisposing factor. OPA were distinguished in three of 209 (1.4%) free-ranging S. guianensis in Sepetiba Bay, Brazil, during winter months of [2005][2006][2007][2008]. Epibiont diatoms are suspected aetiological agents. NOD were chronically present in one male adult Orcinus orca observed off the coast of southern Brazil in 2007-2010. PAD was seen in free-ranging individuals and carcasses of Tursiops truncatus, S. guianensis and Pseudorca crassidens from both the Atlantic and Pacific Oceans in 1992 and in [2004][2005][2006][2007][2008][2009]. Prevalence was 1% in 103 S. guianensis from Paranaguá Estuary (Brazil), 2.3% in 222 S. guianensis from Sepetiba Bay and 6.9% in 87 inshore T. truncatus from Paracas Bay, Peru. Although in some cases the lesions covered up to 35-40% of the visible body surface and ulcers may occur there was no evidence of mortality and, in time-series of six individuals, PAD eventually healed. In six T. truncatus and five S. guianensis acutely affected, PAD was associated with minor cutaneous injuries and scars, including tooth rakes, suggesting infection routes for opportunistic pathogens. EAL were noted in a Cephalorhynchus eutropia calf from Palena province, Chile, in 2003 and in a P. crassidens calf washed ashore dead in southern Brazil in 2009. The C. eutropia calf disappeared, and probably died, two weeks after first observation. Prevalence of EAL was 6.7% in 15 C. eutropia in 2002-2004. These data suggest that EAL are potentially lethal in calves. PAD and EAL were primarily seen in cetaceans inhabiting biologically or chemically contaminated nearshore waters. In view of their emergence and occasional severity these disorders should be the subject of systematic monitoring.

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“…Microscopically, lemon-shaped, budding yeast-like organisms resembling Lacazia loboi (Taborda et al 1999) were detected in skin lesions sampled in T. truncatus (Caldwell et al 1975, Simões-Lopes et al 1993, Paniz-Mondolfi et al 2012, Van Bressem et al 2007) and a S. guianensis from the Americas (Symmers 1983), and in a S. plumbea from South Africa (Lane et al 2014; Table 1). However, recent molecular characterization of the 43 kDa glycoprotein coding gene and of ribosomal DNA from lesions sampled in T. truncatus from the USA and Cuba, and in Indo-Pacific bottlenose dolphins T. aduncus from Japan, indicated that the yeast-like organism infecting these dolphins is more closely related (94−97%) to Paracoccidioides brasiliensis than to L. loboi (Rotstein et al 2009, Esperón et al 2012, Ueda et al 2013. Paracoccidioides spp.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of lobomycosis-like disease in bottlenose dolphins Tursiops spp. from South America and southern Africa

Bressem

Simões-Lopes²,

Félix³

et al. 2015

Dis. Aquat. Org.

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We report on the epidemiology of lobomycosis-like disease (LLD), a cutaneous disorder evoking lobomycosis, in 658 common bottlenose dolphins Tursiops truncatus from South America and 94 Indo-Pacific bottlenose dolphins T. aduncus from southern Africa. Photographs and stranding records of 387 inshore residents, 60 inshore non-residents and 305 specimens of undetermined origin (inshore and offshore) were examined for the presence of LLD lesions from 2004 to 2015. Seventeen residents, 3 non-residents and 1 inshore dolphin of unknown residence status were positive. LLD lesions appeared as single or multiple, light grey to whitish nodules and plaques that may ulcerate and increase in size over time. Among resident dolphins, prevalence varied significantly among 4 communities, being low in Posorja (2.35%, n = 85), Ecuador, and high in Salinas, Ecuador (16.7%, n = 18), and Laguna, Brazil (14.3%, n = 42). LLD prevalence increased in 36 T. truncatus from Laguna from 5.6% in 2007−2009 to 13.9% in 2013−2014, albeit not significantly. The disease has persisted for years in dolphins from Mayotte, Laguna, Salinas, the Sanquianga National Park and Bahía Málaga (Colombia) but vanished from the Tramandaí Estuary and the Mampituba River (Brazil). The geographical range of LLD has expanded in Brazil, South Africa and Ecuador, in areas that have been regularly surveyed for 10 to 35 yr. Two of the 21 LLD-affected dolphins were found dead with extensive lesions in southern Brazil, and 2 others disappeared, and presumably died, in Ecuador. These observations stress the need for targeted epidemiological, histological and molecular studies of LLD in dolphins, especially in the Southern Hemisphere.

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Two Cases of Lacaziosis in Bottlenose Dolphins (Tursiops truncatus) in Japan

Cited by 28 publications

References 26 publications

Cutaneous Granulomas in Dolphins Caused by Novel UncultivatedParacoccidioides brasiliensis

Cutaneous Granulomas in Dolphins Caused by Novel UncultivatedParacoccidioides brasiliensis

Epidemiological characteristics of skin disorders in cetaceans from South American waters

Epidemiology of lobomycosis-like disease in bottlenose dolphins Tursiops spp. from South America and southern Africa

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