Two Cases of Levetiracetam Overdose Without Any Serious Side Effects

doi:10.12996/gmj.2017.39

GMJ

2017

DOI: 10.12996/gmj.2017.39

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Two Cases of Levetiracetam Overdose Without Any Serious Side Effects

Abstract: We present two pediatric cases of levetiracetam overdose. The first case was a 3-year-old girl who was, by her family, accidentally given levetiracetam at 115 mg/kg/day for one-month duration. The second case, a 3-month-old girl who accidentally used 300 mg/kg/day dose about one month. We didn't observe remarkable severe side effects in our patients.

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2019

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Biochemical and histological study on the effect of levetiracetam on the liver and kidney of pregnant albino rats

2019

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Background: Levetiracetam is a broad-spectrum antiseizure agent and one of the most commonly prescribed drugs for epilepsy. The aim of this work was to assess the effect of levetiracetam at its therapeutic range on the liver and kidney of pregnant albino rats. Materials and methods: Forty pregnant rats were divided equally into two groups (I-II), Rats in the group I were gavaged 1.5 mL/day distilled water in two divided doses throughout pregnancy. Rats in the group II were gavaged 1.5 mL/day distilled water (containing 36 mg levetiracetam) in two divided doses throughout pregnancy. At the end of the experiment, blood samples were taken and the sera were separated and used for biochemical analysis. The kidneys and livers of both groups were excised and used for light and electron microscopic examination. Results: Treatment with levetiracetam induced undesirable histopathological changes in the liver and kidney of pregnant albino rats. These changes were in the form of distortion of the hepatic architecture, dilatation of the central and the portal veins, widening of the Bowman's spaces, thickening and disruption of the glomerular basement membrane, fusion and effacement of secondary foot processes, cytoplasmic vacuolation, and swollen mitochondria with loss of their cristae. Such changes were confirmed by alteration of certain biochemical parameters related to the liver and kidney functions. Conclusions: Levetiracetam induced deleterious effects on the liver and kidney of pregnant albino rats. Further investigations are recommended to clarify the mechanism of levetiracetam toxicity. (Folia Morphol 2019; 78, 4: 809-817)

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Biochemical and histological study on the effect of levetiracetam on the liver and kidney of pregnant albino rats

2019

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Two Cases of Levetiracetam Overdose Without Any Serious Side Effects

Cited by 1 publication

References 7 publications

Biochemical and histological study on the effect of levetiracetam on the liver and kidney of pregnant albino rats

Biochemical and histological study on the effect of levetiracetam on the liver and kidney of pregnant albino rats

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