Two cases of listeria rhombencephalitis

Mansbridge, Christopher; Grecu, I.; Chong, Jimmy; Vandervelde, Clive; Saeed, Kordo

doi:10.1016/j.idcr.2017.12.002

“…However, Veesenmeyer and Edmondson, among others, do not recommend the use of ampicillin as empirical treatment for newborn infections after the first week of life because of the low morbidity of listeriosis and high level of antimicrobial resistance of Gram-negative bacteria (Veesenmeyer and Edmonson, 2016); therefore, it is important to diagnose and treat perinatal listeriosis early. As not all samples from listeriosis patients are positive (Mansbridge et al, 2017), contributing to a delay in diagnosis of listeriosis, it is advisable to culture multiple types of sample for listeriosis initially (Awofisayo-Okuyelu et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Listeriosis in mainland China: A systematic review

Fan

¹

,

Xie

²

,

Li

³

et al. 2019

International Journal of Infectious Diseases

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“…Listeria monocytogenes and other infectious inflammatory causes are often cited as the most common etiology of RE (10,11). However, some studies have reported a higher proportion of immunological causes among RE cohorts (4,8).…”

Section: Discussionmentioning

confidence: 99%

Recurrent post-partum rhombencephalitis associated with anti-centromere antibody: A case report

Author)

¹

,

Mamelona

²

,

Harper

³

et al. 2019

Preprint

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Background Rhombencephalitis (RE) is a serious condition of the brain with multiple etiologies. We report a unique case of recurrent, postpartum RE that is associated with positive anti-centromere antibody (ACA). A discussion of the case, current literature on autoimmune RE and related autoantibodies are reviewed. Case Presentation A healthy 33-year-old Caucasian patient (gravida 2, para 2) had two episodes of progressive focal neurological deficits during postpartum periods. Signs and symptoms included right-sided dysmetria, adiadochokinesia, weakness, ataxia, and photophobia. MRI revealed rhombencephalitis involving the mesencephalon. Extensive and comprehensive investigations using blood and cerebrospinal fluid (CSF) were consistently positive only for ACA. The first episode was successfully treated with empiric antimicrobial agents and steroid. Given the negative infectious work up with the prior episode and the nearly identical clinical presentations, the second episode was treated with corticosteroid only. This led to complete resolution of her symptoms and reversal of the brain magnetic resonance imaging (MRI) lesions. Conclusion To the authors’ knowledge, this is the first report of a primary autoimmune RE during postpartum period that is associated with ACA. Immunologic causes should be considered early with any encephalitis. Given the risk of recurrence, relapse, and neurologic deterioration, regular monitoring is recommended, especially for female patients of child-bearing age. Consistent with the current literature on autoimmune RE, steroid seems to be an effective treatment for ACA-associated RE.

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“…Rhombencephalitis (RE) affects individuals of all ages, sex, ethnicity, and immune status (4,8,9). Listeria monocytogenes and other infectious inflammatory causes are often cited as the most common etiology of RE (10,11). However, some studies have reported a higher proportion of immunological etiologies, causing autoimmune RE (4,8).…”

Section: Discussionmentioning

confidence: 99%

Recurrent post-partum rhombencephalitis associated with anti-centromere antibody: A case report

Author)

¹

,

Mamelona

²

,

Harper

³

et al. 2018

Preprint

0

View full text Add to dashboard Cite

Background Rhombencephalitis (RE) is a serious condition of the brain with multiple etiologies. We report a unique case of recurrent, postpartum RE that is associated with positive anti-centromere antibody (ACA). A discussion of the case, current literature on autoimmune RE and related autoantibodies are reviewed. Case Presentation A healthy 33-year-old Caucasian patient (gravida 2, para 2) had two episodes of progressive focal neurological deficits during postpartum periods. Signs and symptoms included right-sided dysmetria, adiadochokinesia, weakness, ataxia, and photophobia. MRI revealed rhombencephalitis involving the mesencephalon. Extensive and comprehensive investigations using blood and cerebrospinal fluid (CSF) were consistently positive only for ACA. The first episode was successfully treated with empiric antimicrobial agents and steroid. Given the negative infectious work up with the prior episode and the nearly identical clinical presentations, the second episode was treated with corticosteroid only. This led to complete resolution of her symptoms and reversal of the brain magnetic resonance imaging (MRI) lesions. Conclusion To the authors’ knowledge, this is the first report of a primary autoimmune RE during postpartum period that is associated with ACA. Immunologic causes should be considered early with any encephalitis. Given the risk of recurrence, relapse, and neurologic deterioration, regular monitoring is recommended, especially for female patients of child-bearing age. Consistent with the current literature on autoimmune RE, steroid seems to be an effective treatment for ACA-associated RE. Keywords: Autoimmune disease, rhombencephalitis, anti-centromere antibody, connective tissue disease, case report

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Two cases of listeria rhombencephalitis

Cited by 19 publications

References 27 publications

Listeriosis in mainland China: A systematic review

Listeriosis in mainland China: A systematic review

Recurrent post-partum rhombencephalitis associated with anti-centromere antibody: A case report

Recurrent post-partum rhombencephalitis associated with anti-centromere antibody: A case report

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