Two Cases of Mitochondrial Diabetes in Which Pancreatic Beta-Cell Function and Neuropathy Were Improved by Glucagon-Like Peptide-1 Receptor Agonist Therapy

Abstract

Mitochondrial diabetes is a refractory type of diabetes mellitus where pancreas beta-cell function attenuates. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) has been reported for pleiotropic effects in addition to effect to glucose tolerance. In animal models, GLP-1RAs were reported to recover mitochondrial function of pancreas beta-cells and increase the growth rate of nerve cells. Our two cases appear to be the first reported cases in the literature of mitochondrial diabetes where GLP-1RAs improved insulin secretion and neuropathy.