“…Effects were seen particularly in the leucocytes and liver (Steinberg et al, 1953 ;Engleman et al, 1954), and fatal cases of generalized visceral involvement were found (O'Brien and Storey, 1954;MacCarthy and Jackson, 1955;Hodge and Lawrence, 1957)., In view of this, the drug was reintroduced at a lower dosage, 200 mg. daily.…”