Two cases of nephrotic syndrome with different etiologies

Mandal, S. K.; Sil, Koelina; Ganguly, Jacky; Chatterjee, Koushik; Chatterjee, Sumanta; Mandal, Souma Sarathi

doi:10.4103/1755-6783.115168

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…Renal amyloidosis resulting from TB has been reported as a cause of nephrotic syndrome with resultant anarsaca [5,6]. Anarsaca has also been reported in patients suffering from TB pericarditis [7,8].…”

Section: Discussionmentioning

confidence: 99%

Anasarca in a 35 year old man- A diagnostic dilemma

Uh¹,

Go²,

S³

2019

Arch Case Rep

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Anasarca is generalized swelling of the body following accumulation of fl uid in the extracellular compartments. It may result from multiple aetiology mainly of renal, hepatic or cardiovascular origin. The aim of this case report is to highlight the challenges encountered in making diagnosis in a patient with anarsaca. We report a case of a 34 year old transporter who presented with anasarca. He had clinical features and risk factors suggestive of renal, hepatic and cardiovascular disease. However investigations ruled out renal, hepatic or cardiovascular diseases as the aetiology of the anarsaca. The anarsarca was also noted to be unresponsive to diuretics. The diagnosis of the disease causing the anarsaca was therefore a dilemma.

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Section: Discussionmentioning

confidence: 99%

Anasarca in a 35 year old man- A diagnostic dilemma

Uh¹,

Go²,

S³

2019

Arch Case Rep

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“…Amyloidosis presented with AKI (54/74, 73.0%), nephrotic syndrome (49/76, 64.5%), and hypertension (20/47, 42.6%). [15,[20][21][22][23][24][25][26] Most cases of amyloidosis in this scoping review did not report whether AIN, crescents or granulomas were present; however, in those cases in which this information was reported, they were consistently absent (0/5). Amyloidosis was attributed to TB in most cases (75/76, 98.7%).…”

Section: Amyloidosismentioning

confidence: 99%

Glomerulonephritis during Mycobacterium Tuberculosis infection: Scoping Review

Forster,

Sabur,

Iqbal

et al. 2024

Preprint

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Introduction People with Tuberculosis (TB) infection may present with glomerulonephritis (GN). The range of presentations, renal pathologies, and clinical outcomes are uncertain. Whether clinical features that establish if GN etiology is medication or TB related, and possible benefits of immunosuppression remain uncertain. Methods A scoping review was completed, searching MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Web of Science and Conference Abstracts from Inception to December, 2023. The study population included patients with TB infection who developed GN and underwent renal biopsy. All data regarding presentation, patient characteristics, renal pathology, management of TB and GN, and outcomes were summarized. Results There were 62 studies identified, with 130 patients. These cases included a spectrum of presentations including acute kidney injury, nephrotic syndrome and hypertension, and a range of 10 different renal pathology diagnoses. Cases that included immunosuppression and outcomes ranged from complete remission to long-term dialysis dependence. The presence of granulomas (4/4, 100%), anti-GBM disease (3/3, 100%), amyloidosis (75/76, 98.7%), and FSGS (2/2, 100%) were specific for GN being TB-infection related. On the other hand, minimal change disease was specific for anti-TB therapy related (7/7, 100%). While patients with more aggressive forms of GN commonly were prescribed immunosuppression, this study was unable to confirm efficacy. Only rifampin or isoniazid were implicated in drug-associated GN. Discussion This study provides a clear rationale for renal biopsy in patients with TB and GN, and outlines predictors for the GN etiology. Thus, this study establishes key criteria to optimize diagnosis and management of patients with TB and GN.

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Insight into the seroepidemiology and dynamics of circulating serotypes of dengue virus over a 4 year period in western Uttar Pradesh, India

MUSTAFA

Khan

Azam

et al. 2023

Access Microbiology

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An important public health problem in India is dengue infection, with every year seeing an increase in cases of dengue fever. Dengue affects all individuals irrespective of their gender and age, although the infection rate is higher among males and younger people. Despite low severity in general, dengue virus can cause severe health conditions in some individuals. Genetic characterization of circulating endemic dengue virus (DENV) serotypes plays a significant role in providing epidemiological knowledge and subsequent vaccine development. In the present study, over a 4 year period, we assessed DENV transmission dynamics in major regions of western Uttar Pradesh in North India. ELISA tests were used to diagnose dengue, and PCRs were used to determine the circulating serotype. We found that dengue infection peaks after the rainy season and affects all sexes and ages. A total of 1277 individuals were found positive for dengue; among them, 61.7 % were male and 38.3 % were female. DEN-1 was found in 23.12 %, DEN-2 in 45 %, DEN-3 in 29.06 % and DEN-4 in 1.5 % of the dengue-infected individuals. All four DENV serotypes were circulating in the study area, and DENV serotype-2 (DEN-2) was the most prevalent serotype.

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Two cases of nephrotic syndrome with different etiologies

Cited by 4 publications

References 11 publications

Anasarca in a 35 year old man- A diagnostic dilemma

Anasarca in a 35 year old man- A diagnostic dilemma

Glomerulonephritis during Mycobacterium Tuberculosis infection: Scoping Review

Insight into the seroepidemiology and dynamics of circulating serotypes of dengue virus over a 4 year period in western Uttar Pradesh, India

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