Two cases of plantar epidermal cyst associated with human papillomavirus

Kato, Naoko; Ueno, Hiroo

doi:10.1111/j.1365-2230.1992.tb02160.x

Cited by 20 publications

(15 citation statements)

References 10 publications

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“…HPV type as HPV type 60. It has been suggested that the HPV-associated PPECs have unique clinical and histopathological characteristics, which distinguish them from ordinary traumatic epidermal cysts of the sole (6). First, they are histopathologically characterized by eosinophilic cytoplasmic inclusion bodies in the epithelial cells of the cyst walls and a vacuolar material in the horny layers within the cysts.…”

Section: Discussionmentioning

confidence: 99%

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Association of Human Papillomavirus Infection with Palmoplantar Epidermal Cysts in Korean Patients

Park¹,

Kim²,

Lee³

et al. 2005

Acta Dermato-Venereologica

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Human papillomavirus (HPV) infection can develop into many different kinds of diseases ranging from simple warts to carcinoma in situ. Some investigators have recently suggested that HPV infection could be closely related to palmoplantar epidermal cysts. The aim of this study was to determine the existence of HPV and its subtype in palmoplantar epidermal cysts of Korean patients. We investigated 13 cases of palmoplantar epidermal cysts by employing clinical, histopathological and immunohistochemical examinations. In addition, PCR was performed using HPV 57 and 60 type primers. Four of the 13 cases (30.8%) showed the distinct histopathological features of palmoplantar epidermal cysts such as parakeratosis, vacuolar structures and eosinophilic inclusion bodies and these 4 cases showed positive immunohistochemical staining reactions for HPV. PCR for HPV detected type 60-positive bands in 5 of the 13 cases (38.5%), which included the 4 cases that were positive for immunohistochemical staining. These results show that HPV is associated with some cases of palmoplantar epidermal cysts in Korean patients, suggesting that HPV may play a role in the pathogenesis of these cysts.

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Section: Discussionmentioning

confidence: 99%

“…Since 1987, there has been evidence presented that human papillomavirus (HPV) is closely related to the occurrence of both palmar (2) and plantar (3)(4)(5)(6)(7)(8) epidermal cysts, especially HPV types 57 and 60 (9)(10)(11).…”

mentioning

confidence: 99%

Association of Human Papillomavirus Infection with Palmoplantar Epidermal Cysts in Korean Patients

Park¹,

Kim²,

Lee³

et al. 2005

Acta Dermato-Venereologica

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“…In previous studies on plantar epidermoid cysts, only the presence of HPV types belonging to group B2 (HPV 4, 48, 50, 60, 65) and A4 (HPV 2-related viruses HPV 2, 27, 57) were analysed. [9][10][11][12][13][14][15][16][17][18][19][20][21] As none of these previous studies analysed the presence of other HPV types, we used consensus primer sets for the detection of HPV types other than these previously detected types. In addition, consensus and type-specific primer sets were used for the detection of group A4 and group B2 HPV types (see Table 1).…”

Section: Human Papillomavirus Dna Analysismentioning

confidence: 99%

“…None of the pathological specimens contained HPV DNAs of one of the HPV types (group B2 and group A4) previously detected in cysts. [9][10][11][12][13][14][15][16][17][18][19][20][21] All pathological specimens contained HPV DNAs of cutaneous and EV-associated types. The cysts were found to contain DNA of EV-associated HPV 20 (variant), 24, alb-7 and 80, which is phylogenetically closely related to the EV-associated HPV type 15, but has features of cutaneous HPV types.…”

Section: Human Papillomavirus Dna Analysismentioning

confidence: 99%

Recurrent 'sterile' verrucous cyst abscesses and epidermodysplasia verruciformis-like eruption associated with idiopathic CD4 lymphopenia

Tobin¹,

Rohwedder

Holland

et al. 2003

Br J Dermatol

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Rupture of follicular (epidermoid) cysts is believed to be the consequence of bacterial infection. We report a 24-year-old man with idiopathic CD4 lymphopenia and chronic Mycobacterium avium intracellulare infection who developed multiple, recurring painful abscesses over the distal extremities that increased in number and severity when systemic steroid and interferon-gamma treatment was instituted for interstitial lung disease. Cultures were consistently negative for microorganisms, but pathological examination revealed ruptured epidermoid cyst walls with human papillomavirus (HPV) viropathic changes (keratinocytes with perinuclear halos and abundant basophilic keratohyaline granules). Cutaneous examination showed numerous, widespread flat-topped papules and achromic macules over the extremities, head and neck. Nested polymerase chain reaction analysis for HPV DNA revealed that the abscess-related cyst walls harboured epidermodysplasia verruciformis (EV)-associated HPV types 20, 24, alb-7 (AY013872) and 80. His cutaneous lesions harboured HPV types 3, 8 and 80. Similar to past reports, our patient developed an EV-like eruption in the setting of immunodeficiency. In this instance, EV-associated HPV infection of the follicular infundibular epithelium or pre-existing cysts in the setting of immunodeficiency may have led to cystic growth, rupture and subsequent painful inflammation.

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“…[3][4][5][6][7] Neither a history of a previous surgery nor verruca-like skin lesions were detected in our patient. However, they occasionally may occur through a different pathomechanism, including deep implantation of the epidermal cells in the course of a blunt penetrating injury, previous surgery, or HPV infections.…”

Section: Discussionmentioning

confidence: 51%