2021
DOI: 10.1016/j.ijscr.2021.106420
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Two cases of primary leiomyosarcoma of sigmoid colon treated with laparoscopic surgery: A case report and a review of literature

Abstract: Introduction and importance Leiomyosarcoma (LMS) of the colon is an extremely rare and highly invasive tumor arising from the muscularis propria of the gastrointestinal tract. After the introduction of oncogenic role of KIT by immunohistochemistry (IHC), the reported cases of gastrointestinal leiomyosarcoma were highly limited. True LMS of the colon is such a rare disorder that there isn't much description of its nature. Case presentation We reported two very rare cases… Show more

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Cited by 9 publications
(9 citation statements)
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“…Based on a search of the main online databases (Embase, PubMed, MEDLINE, and Google Scholar), 37 cases of colonic LMS have been published. Among them, liver metastases were found in eight patients, and two patients were referred for resection for liver metastases, all of which were synchronous metastases[ 5 , 6 ]. One patient was a 74-year-old woman who was diagnosed with a descending colon cancer with liver metastasis in segment 5/6 of the liver.…”
Section: Discussionmentioning
confidence: 99%
“…Based on a search of the main online databases (Embase, PubMed, MEDLINE, and Google Scholar), 37 cases of colonic LMS have been published. Among them, liver metastases were found in eight patients, and two patients were referred for resection for liver metastases, all of which were synchronous metastases[ 5 , 6 ]. One patient was a 74-year-old woman who was diagnosed with a descending colon cancer with liver metastasis in segment 5/6 of the liver.…”
Section: Discussionmentioning
confidence: 99%
“…LMS of the GI tract is extremely rare with an incidence compared to gastrointestinal stromal tumor (GIST) of 1:50-65 [1,5,6]. Its biological behavior is aggressive, and it has a poor prognosis; the response rates of chemotherapy and targeted treatments such as the administration of tyrosine kinase inhibitors, on LMS have been low [7,8], and radiotherapy also seems to be unbeneficial due to radio-resistance [9,10]. Thus, surgical resection has remained the only curative treatment option.…”
Section: Discussionmentioning
confidence: 99%
“…Although the number of reports on the LMS of the GI tract has been limited, the number of reports of minimal invasive surgery for the LMS of the GI tract have been recently increasing with favorable outcomes. A PubMed search using the key words "leiomyosarcoma" and "laparoscopic surgery" since 1998 revealed six case reports (seven patients) of laparoscopic resection of the LMS in the GI tract [6,9,11,[15][16][17]. Among them, two cases were located in the small intestine, one in the stomach, and the remaining four in the colon.…”
Section: Discussionmentioning
confidence: 99%
“…13 In most cases, pcLMS is localized in the sigmoid colon, followed by the ascending colon. 6 Because of nonspecific clinical symptoms and diagnostic signs, an interdisciplinary collaboration between gastroenterologists, radiologists, pathologists, and surgeons is crucial for diagnosing pcLMS in early disease stages. Unclear histological findings of smooth muscle cell tissue in colonic biopsies and a tumor of the colon wall on CT imaging should lead to the differential diagnosis of pcLMS and further diagnostics.…”
Section: Outcome and Follow-upmentioning
confidence: 99%