Two Cases of Russell Body Gastritis Treated by<i>Helicobacter pylori</i>Eradication

Yoon, Jung Bin; Lee, Tae Yeong; Lee, Jin Sook; Yoon, Jong Min; Jang, Se Won; Kim, Min Jung; Lee, Su Jin; Kim, Tae Oh

doi:10.5946/ce.2012.45.4.412

Cited by 21 publications

(22 citation statements)

References 11 publications

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“…It generally happens in the gastric antrum. RBG endoscopic pictures show large whitish lesions and may be mistaken for xanthoma, signet ring cell carcinoma, or malignant lymphoma [22]. RBG reflects a prospective diagnostic pitfall because, for signet ring tumor cells, the distended plasma cells may be mistaken [23].…”

Section: Differential Diagnosismentioning

confidence: 99%

Gastric Xanthoma Associated with Gastric Cancer Development: An Updated Review

Moumin

Mohamed

Osman

et al. 2020

Canadian Journal of Gastroenterology and Hepatology

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Gastric xanthelasma (GX) is a rare tumor-like lesion customarily found as an incidental finding due to its asymptomatic appearance. Grossly, it is a well-marked yellow-white plaque created in the lamina propria by microscopic clusters of foamy macrophages. Xanthelasma is rarely correlated with gastric hyperplastic polyps; gastric xanthomas are rare benign lesions that appear to be associated with inflammation of the gastric mucosa. Etiopathogenesis is also unclear, but it has been suggested to be involved in chronic gastritis, infection with Helicobacter pylori (H. pylori), diabetes mellitus, and hyperlipidemia. e gastric xanthoma prevalence ranges from 0.23% to 7%. Orth first described the condition in 1887. It has been found that xanthelasmas are associated with chronic gastritis, gastrointestinal anastomosis, intestinal metaplasia, and H. pylori infection. ese lesions predispose patients to gastric cancer conditions. Xanthoma (GX) was reported to be a predictive marker for early gastric cancer. However, the effectiveness of these scores and xanthoma (GX) as predictive markers for early gastric cancer detected after H. pylori eradication remains unknown.

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Section: Differential Diagnosismentioning

confidence: 99%

Gastric Xanthoma Associated with Gastric Cancer Development: An Updated Review

Moumin

Mohamed

Osman

et al. 2020

Canadian Journal of Gastroenterology and Hepatology

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“…Endoscopic images of RBG show whitish elevated lesions and can be mistaken as xanthoma, signet ring cell carcinoma, or malignant lymphoma (31).…”

Section: Differential Diagnosismentioning

confidence: 99%

Gastric Xanthoma: A Review of the Literature

et al. 2015

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Context: Xanthelasmas, also known as "xanthomas" and "lipid islands" are yellow plaque-like lesions characterized by the presence of lipid-containing histiocytes. Evidence Acquisition: Xanthomas are most commonly found in the stomach within the gastrointestinal tract, and at this location they are called Gastric Xanthoma (GX). Clinical significance of GX is still unknown. It has been suggested that GX could be related to gastric injury. Here we reviewed five decades of studies on GX in the literature. Results: Since, GXs was reported to be associated with potentially serious conditions of the stomach, the whole gastric mucosa should be examined carefully and biopsy should be taken from the lesion during the upper gastrointestinal endoscopy for diagnosis and rulling out gastric malignity. Conclusions: Gastric xanthomas should not be ignored and concomitant conditions should be treated.

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“…The highly pathogenic Helicobacter pylori genotypes vacA and cagA may also be associated with RBG [23]. The disappearance of Russell bodies following successful Helicobacter pylori eradication therapy also supports the etiopathogenic role of the organism in RBG [1, 3, 7, 10, 11, 13, 15]. In 2006, Stewart and Spagnola reported three cases of Helicobacter -associated gastritis with crystalline plasma cell inclusions, which may represent another morphologic manifestation of immunoglobulin accumulation in response to chronic gastritis [24].…”

Section: Discussionmentioning

confidence: 98%

Russell Body Gastroenteritis: An Aberrant Manifestation of Chronic Inflammation in Gastrointestinal Mucosa

Bhaijee

Brown

Long

et al. 2013

Case Reports in Medicine

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First described in 1998, Russell body gastritis is a rare chronic inflammatory condition characterized by abundant intramucosal polyclonal plasma cells, which contain intracytoplasmic eosinophilic globules of immunoglobulins (Russell bodies) that displace the nucleus, with an accompanying chronic inflammatory infiltrate. Russell bodies represent a cellular response to overstimulation of plasma cells, leading to the accumulation of abundant, nondegradable, condensed immunoglobulin in dilated rough endoplasmic reticulum cisternae. Russell body gastritis usually occurs in the gastric antrum, but two cases of Russell body duodenitis have been recently described. Herein, we report an unusual case of Barrett esophagus with prominent lymphoplasmacytic infiltration and Russell bodies, which expands the current spectrum of Russell body gastritis/duodenitis. Given the various anatomic locations in which Russell body gastritis may arise, we suggest that “Russell body gastroenteritis” may be a more appropriate designation for this uncommon reactive condition.

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Two Cases of Russell Body Gastritis Treated byHelicobacter pyloriEradication

Cited by 21 publications

References 11 publications

Gastric Xanthoma Associated with Gastric Cancer Development: An Updated Review

Gastric Xanthoma Associated with Gastric Cancer Development: An Updated Review

Gastric Xanthoma: A Review of the Literature

Russell Body Gastroenteritis: An Aberrant Manifestation of Chronic Inflammation in Gastrointestinal Mucosa

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