Two cases of spinal meningeal melanocytoma

Iida, Makoto; Llena, Josefina F.; Suárez, Miguel Ángel González; Malik, Shahid M.; Weidenheim, Karen M.; Lasala, Patrick; Hirano, Atsushi

doi:10.1007/bf02482455

Cited by 20 publications

(21 citation statements)

References 22 publications

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“…13,14 To date, approximately 4 cases with multifocal lesions have been reported. 15, 16 Ali et al 6 considered multifocal MM as a distinct pathologic entity that seems to portend an aggressive clinical course and a poor prognosis, even when malignant pathologic features are absent. In our study, 2 patients with multifocal lesions did not show malignant pathologic features compared with those with solitary lesions, but 1 patient with multifocal lesions developed malignant melanoma and died of metastasis 13 months after surgery.…”

Section: Discussionmentioning

confidence: 99%

MR Imaging Findings of the Intraspinal Meningeal Melanocytoma: Correlation with Histopathologic Findings

Hou

Sun

Zhang

et al. 2012

AJNR Am J Neuroradiol

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SUMMARY:Our aim was to better understand and improve the accuracy of the preoperative diagnosis of intraspinal MM by a combined analysis of MR imaging and pathologic findings. All 5 patients had undergone unenhanced and contrast-enhanced MR imaging examinations. All tumor samples had immunohistochemical reactions to HMB-45, vimentin, S-100, EMA, and Leu-7 antibodies. All 5 cases were located in the intradural extramedullary compartment. Two cases had multifocal lesions, and 3 cases were solitary. Two cases showed homogeneously strong enhancement, and 3 cases showed moderate enhancement on contrast-enhanced T1WI. The tumor cells had positive reactions to HMB-45, vimentin, and S-100 antibodies. MR imaging plays an important role in the detection and diagnosis of intraspinal MM. Final diagnosis should be based on histopathology and IHC examinations.ABBREVIATIONS: EMA ϭ epithelial membrane antigen; HMB-45 ϭ human melanoma black-45; IHC ϭ immunohistochemistry; MM ϭ meningeal melanocytoma P rimary melanocytic neoplasms of the CNS are lesions arising from melanocytes of the leptomeninges. Melanocytes are melanin-producing cells that derive from the neural crest during embryogenesis and then migrate to the skin, mucous membranes, and CNS.

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Section: Discussionmentioning

confidence: 99%

MR Imaging Findings of the Intraspinal Meningeal Melanocytoma: Correlation with Histopathologic Findings

Hou

Sun

Zhang

et al. 2012

AJNR Am J Neuroradiol

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“…Limas and Tio (35) fi rst described these lesions in 1972; before this, they were referred to as melanotic meningioma. Approximately 110 cases of meningeal melanocytoma have been reported (34,36).…”

Section: Meningeal Melanocytomamentioning

confidence: 99%

Pigmented Lesions of the Central Nervous System: Radiologic-Pathologic Correlation

Smith¹,

Rushing²,

2009

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Pigmented lesions of the central nervous system (CNS) are a diverse group of entities that run the gamut from benign to malignant. These lesions may be well circumscribed or diffuse, and their imaging appearances are influenced by the degree of melanin content as well as the presence or absence of hemorrhage. Pigmented lesions include primary melanocytic lesions of the CNS and metastatic melanoma, as well as other CNS neoplasms that may undergo melanization, including schwannoma, medulloblastoma, and some gliomas. Primary melanocytic lesions of the CNS arise from melanocytes located within the leptomeninges, and this group includes diffuse melanocytosis and meningeal melanomatosis (seen in neurocutaneous melanosis), melanocytoma, and malignant melanoma. Primary melanin-containing lesions of the CNS must be differentiated from metastatic melanoma because these lesions require different patient workup and therapy. Absence of a known primary malignant melanoma helps in the differential diagnosis, but an occult primary lesion outside the CNS must be sought and excluded. Pigmented lesions of the CNS are uncommon, and knowledge of their imaging characteristics and pathologic features is essential for their identification.

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“…Local recurrences have been described in spinal meningeal melanocytoma. Even totally resected, transformation from melanocytoma to melanoma is a possibility (8,9). Melanocytoma can be misinterpreted as meningioma or schwannoma.…”

Section: Pathological Findingsmentioning

confidence: 99%