Two cases of successful treatment of multilesional cutaneous leishmaniasis with liposomal amphotericin B

Butsch, Florian; Faulde, Michael; Debus, Andrea; Bogdan, Christian; Stebut, Esther von

doi:10.1111/j.1610-0387.2012.08072.x

Cited by 6 publications

(6 citation statements)

References 6 publications

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“…After complexes are formed by amphotericin B and cholesterol on the cell membrane, micropores appear, leading to cell membrane rupture and spillover of cytoplasmic contents (Balasegaram et al, 2012;Butsch et al, 2012). In the absence of supplied exogenous cholesterol, if endogenous cholesterol is used to synthesize inhibitors, the synthesis of endogenous cholesterol is inhibited, preventing the formation of the above complexes and protecting the cells against the damage caused by amphotericin B.…”

Section: Discussionmentioning

confidence: 99%

Hypolipidemic effect of safflower yellow and primary mechanism analysis

Wang¹,

Ren²,

Ma³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. We examined the hypolipidemic effect of safflower yellow (SY) on hyperlipidemic mice and its influence on the biological synthesis of cholesterol in cells. Over 4 weeks, the levels of total cholesterol, triglyceride, low-density lipoprotein cholesterol, and highdensity lipoprotein cholesterol in serum were detected using a kit; mouse liver samples were acquired for paraffin sections, and mouse liver cells were observed under light microscope. Chinese hamster ovary cells were cultured in vitro, and an amphotericin B-cell model was adopted to observe the inhibitory effect of SY on the biological synthesis of intracellular cholesterol. An enzyme-linked immunosorbent assay was used to detect the survival rate of Chinese hamster ovary cells. The middle and high doses of SY significantly reduced the levels of total cholesterol, triglycerides, and low-density lipoprotein cholesterol in the serum of hyperlipidemic mice and low-density lipoprotein cholesterol/ high-density lipoprotein cholesterol ratio (P < 0.05), and the fatty liver of hyperlipidemic mice was significantly alleviated. SY had a protective 6271 Hypolipidemic effect of safflower yellow ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 6270-6278 (2015) effect on Chinese hamster ovary cells following amphotericin B injury (P < 0.01). SY exerts significant hypolipidemic effects and prevents fatty liver in a mechanism associated with inhibition of the biosynthesis of intracellular cholesterol.

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Section: Discussionmentioning

confidence: 99%

Hypolipidemic effect of safflower yellow and primary mechanism analysis

Wang¹,

Ren²,

Ma³

et al. 2015

Genet. Mol. Res.

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“…(Viannia) braziliensis L.amazonensis L ( V ) shawi Cure rate 50%12 monthsHamzavi65Case report1 mg/kg for 1 month; retreated with 3 mg/kg for 2 weeksMultiple nodular, ulcerative. and crusted lesionsNo1 L. major Cure3 monthsIslam663, 4, 4, 5, and 5 mg/kg/day over 5 daysRapidly progressing crustingand ulcerative facial rash—1 L. tropica Cure5 monthsCunha et al67Retrospective studyMean total dose 32.5 mg/kgLesion(s) in the nasal or oral mucosaNo29 L. ( V ) braziliensis Cure rate 93.1%.—Butsch et al 68Case report (two cases)3 mg/kg/day for10 daysNodules on the face, trunk, arm, and footCase 1: noCase 2: diabetic2 L. major Cure24 monthsZanger et al 69Case report3 mg/kg/day for22 daysLesions on the faceTreated rheumatoid arthritis1 L. aethiopica Cure12 monthsOno et al70Case report3 mg/kg/day for 5 consecutive dayswith additional dose on the 10th day for a total of 6 days oftreatmentA tender erythematous nodule on the right elbow—1 L. major Cure—Solomon et al 71 Nonrandomized study with a small number of patientsFive days of 3 mg/kg, followed by a sixth dose on day 10Lesions on the face and/or body—13 L. tropica …”

Section: Cutaneous Leishmaniasismentioning

confidence: 99%

<p>Lipsosomal amphotericin B: a review of its properties, function, and use for treatment of cutaneous leishmaniasis</p>

Shirzadi¹

2019

RRTM

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The genus Leishmania includes a number of protozoan parasites that cause a wide range of infections named leishmaniasis. Leishmaniasis may be appear in three clinical forms — cutaneous (CL), visceral, and mucocutaneous (MCL) — with variation in their presentation and severity: diffuse CL and post–kala-azar dermal leishmaniasis). The prevalent signs of CL are nonhealing ulcers on exposed skin, but infected patients may have other dermatologic symptoms. In the 1960s, amphotericin B deoxycholate was introduced as a second-line therapy for CL and MCL. However, widespread administration of the agent was prevented, due to its renal and systemic toxicity, high price, and obstacles to intravenous use in leishmaniasis-endemic regions. Amphotericin B binds to ergosterol in the photogenic cell membranes and causes changes in membrane permeability, leakage of ions, and finally cell death. Compared to amphotericin B deoxycholate, a higher dose of liposomal amphotericin B should be administered to show the treatment effect. A high percentage of liposomal amphotericin B is “fastened” in the liposome and not biologically effective. Amphotericin B deoxycholate has some toxic effects, and liposomal amphotericin B is meaningfully less toxic compared to it. Treatment options for CL are limited, due to variation in species causing CL and pharmacokinetic issues. Amphotericin B is effective against some particular forms of CL.

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“…L. tropica ist in Nordafrika, dem mittleren Osten, Iran, Afghanistan und der Subsaharazone verbreitet. Dies verleiht L. major und L. tropica Bedeutung als Erreger der Leishmaniasis sowohl bei Reiserückkehrern als auch bei Menschen, die im Rahmen von Migrationsbewegungen nach Deutschland kommen [1][2][3].…”

Section: Epidemiologie Und Verbreitungunclassified

“…Wegen der guten und ausgiebigen Erfahrung der deutschen Kinderärzte mit der i. v. Gabe von liposomalem Amphotericin und der zunehmend guten Datenlage zu dessen Wirksamkeit [3,12] stellt es ein häufig verwendetes Medikament zur Behandlung der Leishmaniasis bei vor allem kleineren Kindern dar.…”

Section: Verlaufsformunclassified

Kutane Leishmaniasis bei Kindern

Butsch¹,

Stebut²

2019

Kinder- und Jugendmedizin

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ZusammenfassungDie kutane Leishmaniasis manifestiert sich in Endemie-Regionen vorwiegend im Kindesalter, als Reise- und Tropendermatose ist sie bereits gut bekannt. Das klinische Spektrum reicht von der selbst-limitierten kutanen Form bis hin zu disseminierten, rezidivierenden und anderen schweren Verlaufsformen. Eine Viszeralisierung tritt bevorzugt bei Immunsuppression und nach Infektion mit besonderen Leishmania-Subspezies auf und muss ggf. ausgeschlossen werden. Die Diagnose wird anhand einer Probebiopsie von der betroffenen Haut gesichert. Die Therapieoptionen für Kinder umfassen mehrere systemische, als auch lokaltherapeutische Verfahren, die im vorliegenden Beitrag kurz beschrieben werden.

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Two cases of successful treatment of multilesional cutaneous leishmaniasis with liposomal amphotericin B

Cited by 6 publications

References 6 publications

Hypolipidemic effect of safflower yellow and primary mechanism analysis

Hypolipidemic effect of safflower yellow and primary mechanism analysis

<p>Lipsosomal amphotericin B: a review of its properties, function, and use for treatment of cutaneous leishmaniasis</p>

Kutane Leishmaniasis bei Kindern

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