In this paper, we determine all simple restricted modules with nonzero level over the twisted Heisenberg-Virasoro algebra D. More precisely, these simple modules are induced modules from simple D (0,−n) -modules, or tensor product modules K(z) D ⊗ U D for some simple modules U ∈ R Vir , K ∈ R H and z ∈ C. This is very different from the case of simple highest weight modules over D which are always tensor products of simple Vir-modules and simple H-modules. We also characterize simple Whittaker modules over D.