2014
DOI: 10.1128/ec.00243-13
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Two-Component Histidine Phosphotransfer Protein Ypd1 Is Not Essential for Viability in Candida albicans

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Cited by 33 publications
(33 citation statements)
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“…There are other possible advantages for a three-component architecture, including combinatorial control of response regulators by sensor proteins through a common phosphotransfer protein or segregation of sensing and activation functions between the nucleus and cytoplasm. Intriguingly, deletion of YPD1 has recently been shown to cause constitutive activation of the HOG pathway in Candida albicans , suggesting that its buffering capacity might also be important in this organism [ 30 ].…”
Section: Discussionmentioning
confidence: 99%
“…There are other possible advantages for a three-component architecture, including combinatorial control of response regulators by sensor proteins through a common phosphotransfer protein or segregation of sensing and activation functions between the nucleus and cytoplasm. Intriguingly, deletion of YPD1 has recently been shown to cause constitutive activation of the HOG pathway in Candida albicans , suggesting that its buffering capacity might also be important in this organism [ 30 ].…”
Section: Discussionmentioning
confidence: 99%
“…The observation that Skn7 is not necessary for C. albicans adaptation to cell wall/osmotic stress suggests that in C. albicans Skn7 is – at least for functions related to filamentation, oxidative stress and osmotic stress tolerance – disconnected from the Sln1/Ypd1 pathway, contrary to what has been observed in S. cerevisiae . This is supported by distinct phenotypes of the C. albicans SLN1, YPD1 and SKN7 null mutants when exposed to osmotic, cell wall or oxidative stress or induced to undergo the yeast‐to‐hypha transition (Nagahashi et al ., ; Yamada‐Okabe et al ., ; Kruppa et al ., ; Singh et al ., ; Mavrianos et al ., ). Mutations of the T484 and T496 residues in the C. albicans Skn7 receiver domain affect both oxidative stress tolerance and morphogenesis.…”
Section: Discussionmentioning
confidence: 99%
“…Most of the information about this class of proteins has been obtained from studies of model yeast S. cerevisiae (Fassler & West, 2013). Ypd1 is essential for viability in S. cerevisiae and C. neoformans (Fassler & West, 2013;Lee et al, 2011) but not in C. albicans (Mavrianos et al, 2014). This apparent difference could be due to mechanisms unique to C. albicans, whereby the phosphotransfer can proceed from the upstream HK to the RR while bypassing Ypd1.…”
Section: Transferases (Hpt)mentioning
confidence: 98%