Two determinations of the Ge-68 half-life

Bergeron, Denis E.; Cessna, Jeffrey T.; Zimmerman, Brian E.

doi:10.1016/j.apradiso.2017.10.038

Cited by 5 publications

(1 citation statement)

References 20 publications

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“…We added 68 Ga 3+ into the hydrogel, cation adsorption capacity of SNs slowed down the release of 68 Ga 3+ in the hydrogel, which was helpful to identify the localization of GNR@SN/Gel in vivo with PET/CT imaging. 68 Ga 3+ has the advantages of easy availability through an 68 Ge/ 68 Ga generator and a short physical half-life of 67.71 min [ 37 ]. As a result, it is helps to understand the initial hydrogel placement without affecting 18 F-FDG myocardial viability on the subsequent day.…”

Section: Discussionmentioning

confidence: 99%

Conductive nanocomposite hydrogel and mesenchymal stem cells for the treatment of myocardial infarction and non-invasive monitoring via PET/CT

et al. 2022

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Background Injectable hydrogels have great promise in the treatment of myocardial infarction (MI); however, the lack of electromechanical coupling of the hydrogel to the host myocardial tissue and the inability to monitor the implantation may compromise a successful treatment. The introduction of conductive biomaterials and mesenchymal stem cells (MSCs) may solve the problem of electromechanical coupling and they have been used to treat MI. In this study, we developed an injectable conductive nanocomposite hydrogel (GNR@SN/Gel) fabricated by gold nanorods (GNRs), synthetic silicate nanoplatelets (SNs), and poly(lactide-co-glycolide)-b-poly (ethylene glycol)-b-poly(lactide-co-glycolide) (PLGA-PEG-PLGA). The hydrogel was used to encapsulate MSCs and 68Ga3+ cations, and was then injected into the myocardium of MI rats to monitor the initial hydrogel placement and to study the therapeutic effect via 18F-FDG myocardial PET imaging. Results Our data showed that SNs can act as a sterically stabilized protective shield for GNRs, and that mixing SNs with GNRs yields uniformly dispersed and stabilized GNR dispersions (GNR@SN) that meet the requirements of conductive nanofillers. We successfully constructed a thermosensitive conductive nanocomposite hydrogel by crosslinking GNR@SN with PLGA2000-PEG3400-PLGA2000, where SNs support the proliferation of MSCs. The cation-exchange capability of SNs was used to adsorb 68Ga3+ to locate the implanted hydrogel in myocardium via PET/CT. The combination of MSCs and the conductive hydrogel had a protective effect on both myocardial viability and cardiac function in MI rats compared with controls, as revealed by 18F-FDG myocardial PET imaging in early and late stages and ultrasound; this was further validated by histopathological investigations. Conclusions The combination of MSCs and the GNR@SN/Gel conductive nanocomposite hydrogel offers a promising strategy for MI treatment. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%