Two-dimensional and 3-dimensional optical coherence tomographic imaging of the airway, lung, and pleura

Hanna, Nevine; Saltzman, David A.; Mukai, David; Chen, Z.; Sasse, Scott A.; Milliken, Jeffrey C.; Guo, Shan; Jung, Woonggyu; Colt, Henri G.; Brenner, Matthew

doi:10.1016/j.jtcvs.2004.10.022

Cited by 113 publications

(81 citation statements)

References 18 publications

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“…OCT can be used to conduct large-volume in vivo microscopy of tissue with resolutions comparable to low-power microscopy (18). OCT has been used to accurately detect and diagnose pathology in vivo for a number of years (17)(18)(19)(20)(21)(22)(23)(24) and has been used to assess the fine microarchitectural features in both normal and pathologic lung (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43).…”

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confidence: 99%

Diagnosing Lung Carcinomas with Optical Coherence Tomography

et al. 2015

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Rationale: Lung carcinoma diagnosis on tissue biopsy can be challenging because of insufficient tumor and lack of architectural information. Optical coherence tomography (OCT) is a high-resolution imaging modality that visualizes tissue microarchitecture in volumes orders of magnitude larger than biopsy. It has been proposed that OCT could potentially replace tissue biopsy.Objectives: We aim to determine whether OCT could replace histology in diagnosing lung carcinomas. We develop and validate OCT interpretation criteria for common primary lung carcinomas: adenocarcinoma, squamous cell carcinoma (SCC), and poorly differentiated carcinoma.Methods: A total of 82 ex vivo tumor samples were included in a blinded assessment with 3 independent readers. Readers were trained on the OCT criteria, and applied these criteria to diagnose adenocarcinoma, SCC, or poorly differentiated carcinoma in an OCT validation dataset. After a 7-month period, the readers repeated the training and validation dataset interpretation. An independent pathologist reviewed corresponding histology. Measurements and Main Results:The average accuracy achieved by the readers was 82.6% (range, 73.7-94.7%). The sensitivity and specificity for adenocarcinoma were 80.3% (65.7-91.4%) and 88.6% (80.5-97.6%), respectively. The sensitivity and specificity for SCC were 83.3% (70.0-100.0%) and 87.0% (75.0-96.5%), respectively. The sensitivity and specificity for poorly differentiated carcinoma were 85.7% (81.0-95.2%) and 97.6% (92.9-100.0%), respectively. Conclusions:Although these results are encouraging, they indicate that OCT cannot replace histology in the diagnosis of lung carcinomas. However, OCT has potential to aid in diagnosing lung carcinomas as a complement to tissue biopsy, particularly when insufficient tissue is available for pathology assessment.

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confidence: 99%

Diagnosing Lung Carcinomas with Optical Coherence Tomography

et al. 2015

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“…Bronchoscopic OCT imaging has been evaluated in ex vivo and in vivo lung pathology [30][31][32][33][34][35][36][37][38][39] and is capable of visualizing the fi ne features of normal airway layering and alveolar attachments. OCT imaging can identify pathologic changes, including preinvasive and preneoplastic airway lesions.…”

Section: Oct Criteria Development For Spn and Lung Parenchymamentioning

confidence: 99%

Toward the Guidance of Transbronchial Biopsy

Hariri

Mino‐Kenudson

Applegate

et al. 2013

Chest

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Background: Solitary pulmonary nodules (SPNs) frequently require transbronchial needle aspiration (TBNA) or biopsy to determine malignant potential, but have variable diagnostic yields. Confi rming needle placement within SPNs during TBNA could signifi cantly increase diagnostic yield. Optical coherence tomography (OCT) provides nondestructive, high-resolution, microstructural imaging with potential to distinguish SPN from parenchyma. We have developed needle-based OCT probes compatible with TBNA. Before OCT can play any signifi cant role in guiding clinical TBNA, OCT interpretation criteria for differentiating SPN from lung parenchyma must be developed and validated. Methods: OCT of SPN and parenchyma was performed on 111 ex vivo resection specimens. OCT criteria for parenchyma and SPN were developed and validated in a blinded assessment. Six blinded readers (two pulmonologists, two pathologists, and two OCT experts) were trained on imaging criteria in a 15-min training session prior to interpreting the validation data set. Results: OCT of lung parenchyma displayed evenly spaced signal-void alveolar spaces, signal-intense backrefl ections at tissue-air interfaces, or both. SPNs lacked both of these imaging features. Independent validation of OCT criteria by the six blinded readers demonstrated sensitivity and specifi city of 95.4% and 98.2%, respectively. Conclusions: We have developed and validated OCT criteria for lung parenchyma and SPN with sensitivity and specifi city . 95% in this ex vivo study. We anticipate that OCT could be a useful complementary imaging modality to confi rm needle placement during TBNA to potentially increase diagnostic yield. CHEST 2013; 144(4):1261-1268Abbreviations: OCT 5 optical coherence tomography; SPN 5 solitary pulmonary nodule; TBNA 5 transbronchial needle aspiration; TB-OCT 5 transbronchial optical coherence tomography

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“…Second-gener- ation OCT (OFDI) is capable of imaging entire bronchial segments, spanning multiple airway generations, and obtaining comprehensive microstructural evaluations in 3 dimensions. Optical coherence tomography has been used to assess the pulmonary airways and parenchyma in animal models [56][57][58][59][60][61] and in vivo human airway. [62][63][64][65][66][67][68] Optical coherence tomography imaging of the normal bronchial wall (Figure 4, A through E) reveals the fine, layered features of the airway, including the epithelium, basement membrane, lamina propria, salivary-type glands and ducts, vessels, and cartilage with surrounding perichondrium.…”

Section: Oct In Pulmonary Imagingmentioning

confidence: 99%

In Vivo Optical Coherence Tomography: The Role of the Pathologist

Hariri

Mino‐Kenudson

Mark

et al. 2012

Archives of Pathology &Amp; Laboratory Medicine

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Optical coherence tomography (OCT) is a nondestructive, high-resolution imaging modality, providing cross-sectional, architectural images at near histologic resolutions, with penetration depths up to a few millimeters. Optical frequency domain imaging is a second-generation OCT technology that has equally high resolution with significantly increased image acquisition speeds and allows for large area, high-resolution tissue assessments. These features make OCT and optical frequency domain imaging ideal imaging techniques for surface and endoscopic imaging, specifically when tissue is unsafe to obtain and/or suffers from biopsy sampling error. This review focuses on the clinical impact of OCT in coronary, esophageal, and pulmonary imaging and the role of the pathologist in interpreting high-resolution OCT images as a complement to standard tissue pathology.

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Two-dimensional and 3-dimensional optical coherence tomographic imaging of the airway, lung, and pleura

Cited by 113 publications

References 18 publications

Diagnosing Lung Carcinomas with Optical Coherence Tomography

Diagnosing Lung Carcinomas with Optical Coherence Tomography

Toward the Guidance of Transbronchial Biopsy

In Vivo Optical Coherence Tomography: The Role of the Pathologist

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