ObjectiveTo assess the impact of scatter radiation on quantitative performance of first and secondâgeneration dualâlayer spectral computed tomography (DLCT) systems.MethodA phantom with two iodine inserts (1 and 2Â mg/mL) configured to intentionally introduce high scattering conditions was scanned with a firstâ and secondâgeneration DLCT. Collimation widths (maximum of 4Â cm for first generation and 8Â cm for second generation) and radiation dose levels were varied. To evaluate the performance of both systems, the mean CT numbers of virtual monoenergetic images (MonoEs) at different energies were calculated and compared to expected values. MonoEs at 50Â versus 150Â keV were plotted to assess material characterization of both DLCTs. Additionally, iodine concentrations were determined, plotted, and compared against expected values. For each experimental scenario, absolute errors were reported.ResultsAn experimental setup, including a phantom design, was successfully implemented to simulate high scatter radiation imaging conditions. Both CT scanners illustrated high spectral accuracy for small collimation widths (1 and 2Â cm). With increased collimation (4Â cm), the secondâgeneration DLCT outperformed the earlier DLCT system. Further, the spectral performance of the secondâgeneration DLCT at an 8Â cm collimation width was comparable to a 4Â cm collimation on the firstâgeneration DLCT. A comparison of the absolute errors between both systems at lower energy MonoEs illustrates that, for the same acquisition parameters, the secondâgeneration DLCT generated results with decreased errors. Similarly, the maximum error in iodine quantification was less with secondâgeneration DLCT (0.45Â and 0.33Â mg/mL for the first and secondâgeneration DLCT, respectively).ConclusionThe implementation of a twoâdimensional antiâscatter grid in the secondâgeneration DLCT improves the spectral quantification performance. In the clinical routine, this improvement may enable additional clinical benefits, for example, in lung imaging.