This chapter introduces the basic principle and recent advances of Brillouin scattering in optical fibers. The working mechanism, different interrogation techniques, difficulty or challenge of the sensing ability, and recent breakthroughs of Brillouin based distributed optical fiber sensors are demonstrated, respectively. 2. Brillouin scattering in optical fibers 2.1. Principle Light scattering phenomena in optical fibers occur regardless of how intense the incident optical power is. They can be basically categorized into two groups, i.e. spontaneous scattering and stimulated scattering[1]. Spontaneous scattering refers to the process under conditions such that the material properties are unaffected by the presence of the incident optical fields.