Two-dimensional oriented growth of Zn-MOF-on-Zr-MOF architecture: A highly sensitive and selective platform for detecting cancer markers

Structural Engineering of Low‐Dimensional Metal–Organic Frameworks: Synthesis, Properties, and Applications

“…The preparation of MOF-MOF composites by heteroepitaxial growth or postsynthetic modification (PSM) has been extensively studied in recent years, although most of reports are limited to bulk MOF crystals. [219] Recently, Lou and co-workers reported a novel MOF-in-MOF structure, which was prepared by reacting presynthesized Febased MIL-88 crystals with Zn 2+ ions and 2-methylimidazole (Figure 11a). [217] Li and co-workers prepared a core-shell ZIF-67@ZIF-8 polyhedron with an external diameter of ≈500 nm through a seed-mediated growth technique.…”

Two-dimensional conductive phthalocyanine-based metal–organic frameworks for electrochemical nitrite sensing

“…17 However, great challenges remain for conventional MOFs due to their poor conductive/electronic properties, so the usage of MOFs in electrochemical applications is dramatically limited. [18][19][20][21] To remove the above challenges, several strategies were put forward, such as (i) pyrolysis of MOFs, in which the carbonized MOFs possessed metal-doped or multi-atom-doped porous carbon, enhancing their electrocatalytic activity; 22,23 (ii) preparation of MOF-based hybrids, with conductive supports (carbon nanotube, graphene, metal foams, etc.) introduced for promoting their electrical conductivity; 24,25 (iii) synthesis of novel conductive MOFs, which can improve the electron transfer capacity directly without pre-treatments.…”

Metal–Organic Framework‐Based Hybrid Frameworks

“…[ 127–129 ] Zhou et al first synthesized bimetallic ZnZr‐based MOFs (Zn‐MOF‐on‐Zr‐MOF and Zr‐MOF‐on‐Zn‐MOF) for sensitive detection of cancer marker PTK7 (protein tyrosine kinase‐7). [ 130 ] Zn‐MOF‐on‐Zr‐MOF‐based aptasensor exhibited stronger binding effect to PTK7, providing ultralow detection limits (LOD) of 0.84 and 0.66 pg mL −1 within the PTK7 concentration range of 0.001–1.0 ng mL −1 . Also, Zn‐MOF‐on‐Zr‐MOF‐based aptasensor exhibited good stability, with no apparent change in response to 0.001 and 1 ng mL −1 PTK7 for 15 d. Considering the good sensing performances of Fe‐MOF and excellent fluorescence property of Tb‐MOF, [ 131,132 ] Wang et al constructed bimetallic TbFe‐based MOF as the platform to anchor carbohydrate antigen 125 (CA125) aptamer for the detection of CA125 and living michigan cancer foundation‐7 (MCF‐7) cells.…”