Two-dimensional silicene photodynamic tumor-targeting nanomedicine

Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application

“…Silicene nanosheets with excellent physiochemical feature and intriguing biocompatibility as a distinct 2D photosensitizer were reported by our group. 1237 The silicene nanosheets exhibited 1 O 2 generation ability under 660 nm laser irradiation, revealing their intriguing PDT application. Furthermore, a 2D hydrogen-bonded silicene nanosystem with tunable bandgap and selective degradability was constructed by Shi et al for tumor-specific PDT.…”

Recent Advances of Emerging Metal-Containing Two-Dimensional Nanomaterials in Tumor Theranostics

“…The 2D silicene material demonstrates remarkable light absorption capabilities. 102 Research findings indicate that the 2D silicene nano photosensitizer exhibits outstanding photostability, superior ability to generate 1 O 2 , and effective PA imaging capabilities, making it suitable for applications in tumor theranostics. The 2D PtBi-PEG nanomaterials developed by Liu et al are capable of PTT and radiotherapy (RT) for the treatment of cancer, as well as exhibiting favorable performance in infrared (IR) imaging, PA imaging and X-ray imaging; thus, these capabilities can be applied to image-guided cancer therapy ( Figure 10C ).…”

Recent progress in emergent two-dimensional silicene

“…109 In the past decade, successful efforts have been made to reveal the potential applications of silicene as biosensors. [109][110][111][112] Hussain et al probed the adsorption mechanism of nucleobases, amino acids, and heterocyclic molecules on silicene and germanene. 110 They found that the abovementioned adsorptions involved both the physical and chemical process, accompanied by the change in the electronic properties of the adsorbent.…”

“…In 2022, based on the similar strategy of wet-chemical synthetic approach, Ruifang Zhang and his collaborators have recently demonstrated the conjunction of c (RGDyC) and silicene nanosheets can serve as a theranostic nanoplatform with considerable biocompatibility with high photostability and superior singlet oxygen 1 O 2 generation capacity by photonic activation to achieve effective photodynamic therapy-based (PDT-based) tumor nanotherapy with a potent in vivo and in vitro photodynamic therapeutic anticancer efficacy under the guidance of photoacoustic imaging for oncotherapy and tumor detection/ monitoring. 112 Due to the unique physical, chemical, and biological properties with the considerable ambient degradability and potent photothermal-promoted degradability, 2D silicene material has the potential to become a platform technology for expanding their application as a biological material. 112,113…”

“…112 Due to the unique physical, chemical, and biological properties with the considerable ambient degradability and potent photothermal-promoted degradability, 2D silicene material has the potential to become a platform technology for expanding their application as a biological material. 112,113…”