Two-dimensional transition metal chalcogenide nanomaterials for cancer diagnosis and treatment

Wu, Jingjing; Hu, Tingting; GuopingZhao,; Li, Anran; Liang, Ruizheng

doi:10.1016/j.cclet.2021.12.080

Cited by 17 publications

(14 citation statements)

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“…Magnesium possesses outstanding biocompatibility and osteogenesis properties (Figure 7A). [256][257][258][259][260] As a metal biomaterial, magnesium is strong enough to meet the mechanical requirements for repairing ONFH. [261] Unlike other metals with much higher mechanical properties than natural bones that cause stress shielding effects, the mechanical property of magnesium is similar to that of natural cortical bones.…”

Section:  Magnesiummentioning

confidence: 99%

Bone tissue engineering for treating osteonecrosis of the femoral head

Bian

et al. 2023

Exploration

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Osteonecrosis of the femoral head (ONFH) is a devastating and complicated disease with an unclear etiology. Femoral head-preserving surgeries have been devoted to delaying and hindering the collapse of the femoral head since their introduction in the last century. However, the isolated femoral head-preserving surgeries cannot prevent the natural progression of ONFH, and the combination of autogenous or allogeneic bone grafting often leads to many undesired complications. To tackle this dilemma, bone tissue engineering has been widely developed to compensate for the deficiencies of these surgeries. During the last decades, great progress has been made in ingenious bone tissue engineering for ONFH treatment. Herein, we comprehensively summarize the state-of-the-art progress made in bone tissue engineering for ONFH treatment. The definition, classification, etiology, diagnosis, and current treatments of ONFH are first described. Then, the recent progress in the development of various bone-repairing biomaterials, including bioceramics, natural polymers, synthetic polymers, and metals, for treating ONFH is presented. Thereafter, regenerative therapies for ONFH treatment are also discussed. Finally, we give some personal insights on the current challenges of these therapeutic strategies in the clinic and the future development of bone tissue engineering for ONFH treatment. K E Y WO R D S biomaterials, bone tissue engineering, osteonecrosis of the femoral head, regenerative therapy  Yixin Bian and Tingting Hu contributed equally to this work.

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Section:  Magnesiummentioning

confidence: 99%

Bone tissue engineering for treating osteonecrosis of the femoral head

Bian

et al. 2023

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“…FT-IR (ATR); cm À1 : 3333 (O-H), 1622 (C=N), 1592 (C=C). 1 Synthesis of axially bis-4-[(E)-{[(pyridin-3-yl)methyl]imino}methyl] phenol substituted silicon (IV) phthalocyanine (2b). A mixture of compound 1b (0.14 g, 6.54 9 10 À4 mol), K 2 CO 3 (0.18 g, 13.08 9 10 À4 mol) and SiPcCl 2 (0.2 g, 3.27 9 10 À4 mol) in 25 mL dry toluene was refluxed by stirring under argon atmosphere for 36 h. After completion of the reaction, solvent was evaporated, and solid phase was washed with methanol.…”

Section: Synthesismentioning

confidence: 99%

“…As shown in Scheme 1, axially Schiff base substituted SiPcs were synthesized. Ligands and complexes were characterized by FT-IR, UV-Vis, 1 H NMR and Mass spectroscopic techniques and their photophysical-photochemical properties were analyzed. Spectroscopic data of the ligands and complexes were found as expected.…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

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Comparing Singlet Oxygen Generation of Schiff Base Substituted Novel Silicon Phthalocyanines by Sonophotochemical and Photochemical Applications

Ünlü

Atmaca

Elmalı

et al. 2023

Photochem & Photobiology

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Although the sonophotodynamic method has an effective therapeutic outcome for anticancer treatment compared with the photodynamic method, there are not enough related studies in the literature and this study aims to contribute to the development of sonophotodynamic studies. For this purpose, the Schiff base substituted silicon phthalocyanines were designed and synthesized as effective sensitizer candidates and the photophysicochemical and sonophotochemical features of the phthalocyanines were examined to increase singlet oxygen efficiency. The calculated ΦΔ values indicate that the contribution of substituent groups improved the production of singlet oxygen compared with silicon (IV) phthalocyanine dichloride (SiPcCI2) and also the sonophotochemical applications increased the singlet oxygen yields. The ΦΔ values (ΦΔ = 0.76 for axially bis‐{4‐[(E)‐(pyridin‐3‐ylimino)methyl]phenol} substituted silicon (IV) phthalocyanine (2a), 0.68 for axially bis‐4‐[(E)‐{[(pyridin‐3‐yl)methyl]imino}methyl]phenol substituted silicon (IV) phthalocyanine (2b) in photochemical study) reached to ΦΔ = 0.98 for 2a, 0.94 for 2b in sonophotochemical study. This article will enrich the literature on increasing singlet oxygen yield.

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“…Nanomaterials based on transition metal chalcogenides (TMCs) have been inciting tremendous interest in research related to the optoelectronics field in the past few decades. TMCs showed a broad spectrum of applications ranging from photoelectric devices, energy storage and conversion devices, catalysis for water treatment and hydrogen generation, bioimaging, and cancer treatment, which are attributable to their intriguing chemical and physical properties. − In the family of TMCs, copper selenides stood out as an intriguing class of materials due to their tendency to assemble in a wide variety of stoichiometric and nonstoichiometric compositions, making them a paradigm of materials engineering because of their broad range of physical, optical, electronic, and magnetic functionalities that are likely to be customized by reconfiguring the elemental composition as well as stoichiometry. − Copper selenides are semiconductors of immense importance owing to their exclusive plasmonic, luminescent, tunable photoelectrical properties with broad band gaps (1.2–2.3 eV), prominent charge carrier mobilities, high carrier densities, superior thermal stability, and so forth. , Their improved environmental remediation is attributed to their affordability, nonhazardous nature, and environmental suitability. − Copper selenides are quite diverse p-type semiconductors that exist in a wide variety of stoichiometric as well as nonstoichiometric forms of Cu 2– x Se (2.00 ≥ 2 – x ≥ 1.72). ,, …”

Section: Introductionmentioning

confidence: 99%

Pristine, Ni- and Zn-Doped CuSe Nanoparticles: An Antimicrobial, Antioxidant, and Cytotoxicity Study

Patel

Chaki

Giri

et al. 2023

ACS Appl. Bio Mater.

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The strategy of chemical coprecipitation is implemented to synthesize nanoparticles of pristine CuSe, 5 and 10% Nidoped CuSe, and 5 and 10% Zn-doped CuSe. All of the nanoparticles are found to be near stoichiometric by the evaluation of X-ray energy using electron dispersion spectra, and the elemental mapping shows uniform distribution. By X-ray diffraction examination, all of the nanoparticles are identified as being single-phase and having a hexagonal lattice structure. Field emission microscopy with electrons in both scanning and transmission modes affirmed the spherical configuration of the nanoparticles. The crystalline nature of the nanoparticles is confirmed by the presence of spot patterns observed in the selected area electron diffraction patterns. The observed d value matches well with the d value of the CuSe hexagonal (102) plane. Findings from dynamic light scattering reveal the size distribution of nanoparticles. The nanoparticle's stability is investigated by ζ potential measurements. Pristine and Ni-doped CuSe nanoparticles exhibit ζ potential values in the preliminary stability band of ±10 to ±30 mV, while Zn-doped nanoparticles feature moderate stability levels of ±30 to ±40 mV. The potent antimicrobial effects of synthesized nanoparticles are studied against Staphylococcus aureus, Pseudomonas aeruginosa, Proteus vulgaris, Enterobacter aerogenes, and Escherichia coli bacteria. The 2,2-diphenyl-1-picrylhydrazyl scavenging test is used to investigate the nanoparticle's antioxidant activities. The results showed the highest activity for control (Vitamin C) with an IC 50 value of 43.6 μg/mL, while the lowest for Nidoped CuSe nanoparticles with an IC 50 value of 106.2 μg/mL. Brine shrimps are utilized for in vivo cytotoxicity evaluation of the synthesized nanoparticles, which demonstrates that 10% Ni-and 10% Zn-doped CuSe nanoparticles are more damaging on brine shrimp instead on other nanoparticles with a 100% mortality rate. The lung cancer cell line of human (A549) is used to investigate in vitro cytotoxicity. The results indicate that pristine CuSe nanoparticles are more effective in the context of cytotoxicity against the A549 cell lines, possessing an IC 50 of 488 μg/mL. The particulars of the outcomes are explained in depth.

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Two-dimensional transition metal chalcogenide nanomaterials for cancer diagnosis and treatment

Cited by 17 publications

References 124 publications

Bone tissue engineering for treating osteonecrosis of the femoral head

Bone tissue engineering for treating osteonecrosis of the femoral head

Comparing Singlet Oxygen Generation of Schiff Base Substituted Novel Silicon Phthalocyanines by Sonophotochemical and Photochemical Applications

Pristine, Ni- and Zn-Doped CuSe Nanoparticles: An Antimicrobial, Antioxidant, and Cytotoxicity Study

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