Two examples of Renbök phenomenon in dermatophytosis sparing congenital nevi

Happle, Rudolf; Wollina, Uwe; Verma, Shyam

doi:10.1111/jdv.17417

Cited by 4 publications

(5 citation statements)

References 9 publications

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“…34 This concept has been applied to illustrate different clinical settings. 35,36 It has been suggested that the different T-helper (Th) inflammatory subsets may play a key role in the competition between these two immune-related diseases. Psoriatic inflammation may antagonize the inflammatory reactions in alopecia areata.…”

Section: Other Subtypes Of Kpmentioning

confidence: 99%

“…Bon et al observed that a patient with alopecia areata began to show hair growth locally after psoriatic lesions on the scalp and proposed Renbök phenomenon to describe this phenomenon 34 . This concept has been applied to illustrate different clinical settings 35,36 . It has been suggested that the different T‐helper (Th) inflammatory subsets may play a key role in the competition between these two immune‐related diseases.…”

Section: Overview Of Kpmentioning

confidence: 99%

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Characteristics and pathogenesis of Koebner phenomenon

Zhang

Jiang

et al. 2022

Experimental Dermatology

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The Koebner phenomenon, also known as isomorphic reaction, refers to the development of secondary lesions with the same clinical manifestations and histopathological characteristics as the primary lesions in normal skin after trauma or other stimuli. The triggering factors of Koebner phenomenon include physical trauma, chemical stimulation, mechanical stress, iatrogenic stimulation and pathogenic infection. Vitiligo, psoriasis and lichen planus are considered true Koebner phenomenon. Recent studies have shown that immunological disorders, oxidative stress, defective melanocyte adhesion and growth factor deficiency are the main pathological mechanisms of vitiligo Koebner phenomenon. In psoriasis, triggers may drive skin inflammation to induce a psoriatic phenotype through multiple signalling pathways and thereby cause Koebner phenomenon in susceptible individuals. Significantly, keratinocytes mediate the occurrence of Koebner phenomenon in psoriasis through mechano‐induced signalling pathways after sensing mechanical signals and explains the high frequency of psoriasis lesions on the extensor side of the elbow and knee joints. On the contrary, TRPA1‐driven mechano‐transduction, autoimmunity and actinic damage are the underlying mechanisms of Koebner phenomenon in lichen planus. In this review, we have summarized the current understanding of the characteristics and pathogenesis of Koebner phenomenon.

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Section: Other Subtypes Of Kpmentioning

confidence: 99%

Section: Overview Of Kpmentioning

confidence: 99%

Characteristics and pathogenesis of Koebner phenomenon

Zhang

Jiang

et al. 2022

Experimental Dermatology

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“…This uncommon clinical manifestation consists of the absence of lesions of a usually generalized dermatosis in a previously damaged skin area (due to physical or chemical damage or to a previous dermatosis). 3 This concept has been applied to illustrate different clinical settings: patients with alopecia areata sparing areas with psoriasis, 4 dermatophytosis sparing congenital nevi 5 or occasional cases of leukocytoclastic vasculitis sparing a tattoo. 6 It has also been reported in some drug eruptions, Stevens-Johnson F I G U R E 1 Case of sparing phenomenon (post-irradiation Renbok phenomenon) in a patient with erythema multiforme.…”

Section: Post-irradiation Renbok Phenomenon In Erythema Multiforme: R...mentioning

confidence: 99%

Post‐irradiation Renbok phenomenon in erythema multiforme: Report of a case sparing previously irradiated areas

Bertolín‐Colilla

Olmos-Alpiste

Dios

et al. 2022

Acad Dermatol Venereol

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“…As summarized in a recent report of Happle et al 6 nevi of various types can be associated with a Renb€ ok phenomenon. It was reported to occur in the course of alopecia areata (including alopecia totalis and alopecia universalis), guttate psoriasis, and generalized drug eruption.…”

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confidence: 93%

Frontal fibrosing alopecia sparing a dermal melanocytic nevus: a report of two cases of Renbök phenomenon

Sławińska

Sokołowska‐Wojdyło

Sobjanek

et al. 2022

Acad Dermatol Venereol

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EditorFrontal fibrosing alopecia (FFA) is a type of primary scarring alopecia, which primarily affects postmenopausal women and is marked by progressive recession of frontotemporal hairline. 1 Despite growing incidence in the recent years, the potential triggering factors remain unclear. 2 Immunohistochemical studies show the role of immune system in disease pathogenesis. 3 Renb€ ok phenomenon (inverse K€ obner phenomenon) refers to a clinical scenario in which the presence of one skin condition prevents the development of another. 4 Recently, Nemazee et al. 5 reported it in a patient with FFA, in whom the area affected with vascular nevus was spared from cicatricial alopecia. Herein, we report two cases of patients with FFA sparing dermal nevi.The first patient was a 62-year-old woman (phototype II), with hypothyroidism, who presented to the outpatient clinic due to increasing regression of hairline in frontal and temporal areas associated with loss of eyebrows. The disease started 4 years previously. Based on clinical, trichoscopic and histopathological features, FFA was diagnosed. During clinical and histopathological assessment of the area involved by FFA showing a few lonely hairs, a dermal melanocytic nevus with preserved hairs was noted (Fig. 1a-e).Data sharing not applicableno new data generated.

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Two examples of Renbök phenomenon in dermatophytosis sparing congenital nevi

Cited by 4 publications

References 9 publications

Characteristics and pathogenesis of Koebner phenomenon

Characteristics and pathogenesis of Koebner phenomenon

Post‐irradiation Renbok phenomenon in erythema multiforme: Report of a case sparing previously irradiated areas

Frontal fibrosing alopecia sparing a dermal melanocytic nevus: a report of two cases of Renbök phenomenon

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