Two Faces of SIVA

Resnick‐Silverman, Lois; Manfredi, James J.

doi:10.1158/2159-8290.cd-15-0484

Cited by 3 publications

(1 citation statement)

References 11 publications

(12 reference statements)

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“…Importantly, Siva-1 has been clearly recognized as an oncogenic factor in a mutant KRAS-dependent mouse model of non-small-cell lung cancer (NSCLC) and in human NSCLC cells in culture. 42 , 43 Siva-1 knockout mice were generated, in which the whole gene was deleted, flanked by a LoxP and a LoxP-Puro-LoxP cassette. Homozygous Siva-1- null animals revealed embryonic lethality after expressing Cre recombinase (Ad-Cre).…”

Section: Siva-1 As An Oncogene In Nsclc Cellsmentioning

confidence: 99%

Siva-1 emerges as a tissue-specific oncogene beyond its classic role of a proapoptotic gene

Vachtenheim

Lischke

2018

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Siva-1 is a typical apoptotic protein commonly activated by the p53 tumor suppressor protein and should therefore participate in a barrier against the development of cancer. It has proapoptotic activities in various cell systems. Recent findings suggest that Siva-1 possesses several other apoptosis-independent functions and interacts with many other proteins not directly involved in apoptosis. It harbors the ARF E3 ubiquitin protein ligase activity, a property that is clearly prooncogenic and leads to p53 degradation through the upregulation of the Hdm2 protein level. Surprisingly, recent evidence shows that Siva-1 absence prevents the development of non-small cell lung carcinomas in a mouse model and reveals the oncogenic roles in the same types of human cells, indicating its unique function as an oncogene in the cell context-dependent manner. Herein, we review reported activities of Siva-1 in various experimental settings and comment on its ambiguous function in tumor biology.

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Section: Siva-1 As An Oncogene In Nsclc Cellsmentioning

confidence: 99%

Siva-1 emerges as a tissue-specific oncogene beyond its classic role of a proapoptotic gene

Vachtenheim

Lischke

2018

OTT

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SIVA-1 enhances acquired chemotherapeutic drug resistance of gastric cancer in vivo by regulating the ARF/MDM2/p53 pathway

Wang,

Li,

Zhu

et al. 2024

Heliyon

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Screening of Candidate Key Genes Associated with Congenital Heart Disease Using Bioinformatics Data Analysis

Zhang

Sun

et al. 2021

J. Phys.: Conf. Ser.

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Congenital heart disease (CHD) is one of the most dangerous diseases seen in daily life. Aim of this study is to find the deep causes of congenital heart disease. The GSE35776 chip data was extracted from the Gene Expression Synthesis Database (GEO). Analyzing above data was using the R language. The enrichment pathways of differentially expressed genes were processed using the Kyoto Encyclopedia of Genes and Genomics (KEGG) and gene ontology (GO) database. Then this study uses Cytoscape and GCBI to structure protein-protein interaction (PPI) networks, gene regulation networks. 257 differentially expressed genes (DEGs) were found out, mainly focusing on cell cycle, oocyte meiosis, p53 signaling pathway and progesterone mediated oocyte maturation. By constructing gene regulation network, 12 hub genes were screened, including NUF2, BUB1, CENPI, CCNB2, SGO1, SMC4, NCAPD2, TUBB and NCAPH. We hypothesized that these 12 genes may be key factors in CHD.

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Two Faces of SIVA

Cited by 3 publications

References 11 publications

Siva-1 emerges as a tissue-specific oncogene beyond its classic role of a proapoptotic gene

Siva-1 emerges as a tissue-specific oncogene beyond its classic role of a proapoptotic gene

SIVA-1 enhances acquired chemotherapeutic drug resistance of gastric cancer in vivo by regulating the ARF/MDM2/p53 pathway

Screening of Candidate Key Genes Associated with Congenital Heart Disease Using Bioinformatics Data Analysis

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