The problem of intertwined Hamiltonians in two dimensional curved spaces is investigated.Explicit results are obtained for Euclidean plane,Minkowski plane, Poincaré half plane (AdS 2 ), de Sitter Plane (dS 2 ), sphere, and torus. It is shown that the intertwining operator is related to the Killing vector fields and the isometry group of corresponding space. It is shown that the intertwined potentials are closely connected to the integral curves of the Killing vector fields. Two problems of considered as applications of the formalism presented in the paper. The first one is the problem of Hamiltonians with equispaced energy levels and the second one is the problem of Hamiltonians whose spectrum are like the spectrum of a free particle. *