Two fatal cases of eosinophilic myeloencephalitis a newly recognized disease caused by Gnathostoma spinigerium

Punyagupta, Sompone; Juttijudata, P; Bunnag, T; Comer, D. S.

doi:10.1016/0035-9203(68)90008-4

Cited by 27 publications

(2 citation statements)

References 7 publications

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“…The most common clinical manifestation is subcutaneous or cutaneous intermittent migratory swelling. Most importantly, L3 may migrate to the central nervous system (CNS) and cause serious effects such as myeloencephalitis and meningitis with long-term sequelae or even death (Chitanondh and Rosen 1967;Punyagupta and Juttijudata 1968;Boongird et al 1977;Schmutzhard et al 1988). Gnathostomiasis is one of the three most common parasitic infections that involve the CNS in Thailand (Vejjajiva 1978;Tuntipopipat et al 1989).…”

Section: Introductionmentioning

confidence: 98%

Study of specific IgG subclass antibodies for diagnosis of Gnathostoma spinigerum

Nuchprayoon

Sanprasert

Suntravat

et al. 2003

Parasitology Research

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Gnathostoma spinigerum infection is endemic in Thailand and many Asian countries. Current diagnosis is the skin test and enzyme-linked immunosorbent assay (ELISA) for IgG antibody against the G. spinigerum third-stage larvae (L3), but cross-reactivity is common. We evaluated the sensitivity and specificity of anti-G. spinigerum L3 IgG subclass antibodies for diagnosis of 43 patients with gnathostomiasis. The majority of patients with gnathostomiasis (91%) had eosinophilia. While the anti-G. spinigerum L3 IgG1 antibody provided the highest sensitivity (98%), the anti-G. spinigerum L3 IgG2 antibody had the highest specificity (88%). The ELISA that detected anti-G. spinigerum L3 IgG1 antibody could be a reliable laboratory screening test, while anti-G. spinigerum L3 IgG2 antibody could be used to confirm the diagnosis.

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Section: Introductionmentioning

confidence: 98%

Study of specific IgG subclass antibodies for diagnosis of Gnathostoma spinigerum

Nuchprayoon

Sanprasert

Suntravat

et al. 2003

Parasitology Research

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“…is characterized by erythrocytes in cerebrospinal fluid (CSF) ( 33 ), which suggests mechanical damage by the worm. Apart from the structural damage, the inflammatory response to the migrating larvae might further contribute to tissue destruction ( 34 ). …”

Section: Pathophysiology Of Neurognathostomiasismentioning

confidence: 99%

Neurognathostomiasis, a Neglected Parasitosis of the Central Nervous System

Katchanov¹,

Sawanyawisuth²,

Chotmongkol³

et al. 2011

Emerg. Infect. Dis.

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Gnathostomiasis is a foodborne zoonotic helminthic infection caused by the third-stage larvae of Gnathostoma spp. nematodes. The most severe manifestation involves infection of the central nervous system, neurognathostomiasis. Although gnathostomiasis is endemic to Asia and Latin America, almost all neurognathostomiasis cases are reported from Thailand. Despite high rates of illness and death, neurognathostomiasis has received less attention than the more common cutaneous form of gnathostomiasis, possibly because of the apparent geographic confinement of the neurologic infection to 1 country. Recently, however, the disease has been reported in returned travelers in Europe. We reviewed the English-language literature on neurognathostomiasis and analyzed epidemiology and geographic distribution, mode of central nervous system invasion, pathophysiology, clinical features, neuroimaging data, and treatment options. On the basis of epidemiologic data, clinical signs, neuroimaging, and laboratory findings, we propose diagnostic criteria for neurognathostomiasis.

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Gnathostomiasis

Kagen¹

1984

Arch Dermatol

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Two fatal cases of eosinophilic myeloencephalitis a newly recognized disease caused by Gnathostoma spinigerium

Cited by 27 publications

References 7 publications

Study of specific IgG subclass antibodies for diagnosis of Gnathostoma spinigerum

Study of specific IgG subclass antibodies for diagnosis of Gnathostoma spinigerum

Neurognathostomiasis, a Neglected Parasitosis of the Central Nervous System

Gnathostomiasis

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