Two Flavones from &amp;lt;i&amp;gt;Acanthospermum hispidum&amp;lt;/i&amp;gt; DC and Their Antibacterial Activity

Edewor, Theresa Ibibia; Olajire, Abass A.

doi:10.4236/ijoc.2011.13020

Cited by 13 publications

(10 citation statements)

References 16 publications

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“…Our result has noted the lack of anthracene in our extract. This result confirms those of Edewor and Olajire (2011), which also noted the lack of anthracene.…”

Section: Discussionsupporting

confidence: 90%

“…Our result confirms those of Roy et al (2010), which have already noted the presence of these chemical groups in the leaves of A. hispidum. Edewor and Olajire (2011), have noted the lack of alkaloids and cardiac glycosides in the aerial parts of A. hispidum. Our result has noted the lack of anthracene in our extract.…”

Section: Discussionmentioning

confidence: 99%

“…It was reported that A. hispidum contains some chemicals such as sesquiterpenes and lactones (Jakupovic et al, 1986;Arena et al, 2011). Secondary metabolites such us acanthospermol galactoside, flavones, cafeic acid, ciscis-germacranolides, melampolides and β-caryophyllene have been reported to be present in the aerial part of the plant (Edewor and Olajire, 2011). Despite these proven pharmacological properties, caution must be put in its use by the people because little study has focused on his toxicity (Ali and Adam, 1978).…”

Section: Introductionmentioning

confidence: 99%

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Toxicological Study of Hydroalcohol Leaf Extract of Acanthospermum hispidum (Asteraceae)

Diallo

Salem

Badjabaissi

et al. 2020

American Journal of Pharmacology and Toxicology

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Acanthospermum hispidum is a widely plant used in African traditional medicine. This study aims to assess cardiotoxicity and subchronic (28-days) oral toxicity of hydroalcohol leaf extract of A. hispidum. The sub-chronic toxicity was evaluated after administering daily oral doses of 500 and 1000 mg/kg body wt., for 28 days to the rats, biochemical and haematological assessments as well as body and relative organ weights of the rats were carried out. The results of the study have shown that blood sodium was significantly (p < 0.05) lower in the group treated with 500 and 1000 mg/kg of A. hispidum extract and the blood platelet was significantly high. The weekly body and organ weight of the rats showed no significant differences between the control and the rats treated with the extract except for the testis where there was a significant decrease (p < 0.05) in rats that received 1000 mg/kg, i.e., 1.16±0.2 g against 0.78±0.22 g for the control. A discreet seminiferous tubular atrophy and fibrosis of the tube wall were observed at this dose. The hydroalcoholic extract of A. hispidum at 0.1; 1; 10 and 100 mg/ml on toad heart and isolated atria of guinea pigs have caused a significant increase in cardiac amplitude (positive inotropic) and a significant decrease (p < 0.0001) in frequency (negative chronotropism). Our results suggest that the hydroalcohol extract of A. hispidum is relatively toxic to the testis and caution must be taken at high doses especially for the heart.

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“…Our result has noted the lack of anthracene in our extract. This result confirms those of Edewor and Olajire (2011), which also noted the lack of anthracene.…”

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Toxicological Study of Hydroalcohol Leaf Extract of Acanthospermum hispidum (Asteraceae)

Diallo

Salem

Badjabaissi

et al. 2020

American Journal of Pharmacology and Toxicology

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“…The A. hispidum extract presented activity only against S. oralis. The study conducted by Ederwor and Olajire [ 30 ] confirms the antimicrobial activity of the extracts of P. aeruginosa and S. aureus .…”

Section: Resultsmentioning

confidence: 82%

Study Bioprospecting of Medicinal Plant Extracts of the Semiarid Northeast: Contribution to the Control of Oral Microorganisms

Silva

Brandão

Chaves

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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Dental pathologies can be caused by plaque-forming bacteria and yeast, which reside in the oral cavity. The bacteria growing in dental plaque, a naturally occurring biofilm, display increased resistance to antimicrobial agents. The objective was the evaluation of a preclinical assay of medicinal plants of the semiarid region from the northeast against oral pathogenic microorganism, aiming at bioprospecting a new product. The selection of plant material for this study was based on the ethnobotanical data on the traditional use of plants from the semiarid region. The thirty extracts were subjected to the determination of antibiofilm activity against gram-positive, gram-negative bacteria and yeast. The hydroalcoholic extract which showed positive antibiofilm activity against most of the microorganisms tested in agar diffusion assay was further tested for the determination of minimum inhibitory concentration (MIC) and Bioassay with Artemia salina. Plant samples tested in this study exhibited good antibiofilm activity for the treatment of oral problems. The Schinopsis brasiliensis showed greater activity for Pseudomonas aeruginosa and Staphylococcus aureus, but toxicity against Artemia salina.

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“…In addition, glycosides and flavonoids have been reported to be present in the aerial part of the plant (Nair et al, 1976;Edewor and Olajire, 2011). A. hispidum has been shown to be a potentially useful plant in the treatment of protozoan infections; though, the antitrichomonal activity had not been reported.…”

Section: Introductionmentioning

confidence: 99%

Antitrichomonal activity of Acanthospermum hispidum D. C. (Asteraceae)

Adepiti¹,

Adewunmi²,

Agbedahunsi³

2014

Afr. J. Biotechnol.

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Acanthospermum hispidum (Asteraceae), used ethnomedically in the treatment of inflammatory conditions and fever, was evaluated for antiprotozoal activities such as trypanocidal and antiplasmodial effects. This study was carried out to investigate the anti-trichomonal potential of the plant. The airdried leaf was extracted successively with petroleum ether, chloroform, ethylacetate and methanol using the soxhlet extraction method. Bioactivity-guided fractionation of the most active extract was carried out using the vacuum liquid chromatographic technique for antitrichomonal activity using

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Two Flavones from <i>Acanthospermum hispidum</i> DC and Their Antibacterial Activity

Cited by 13 publications

References 16 publications

Toxicological Study of Hydroalcohol Leaf Extract of Acanthospermum hispidum (Asteraceae)

Toxicological Study of Hydroalcohol Leaf Extract of Acanthospermum hispidum (Asteraceae)

Study Bioprospecting of Medicinal Plant Extracts of the Semiarid Northeast: Contribution to the Control of Oral Microorganisms

Antitrichomonal activity of Acanthospermum hispidum D. C. (Asteraceae)

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