Two fluorinated thulium complexes as molecular temperature sensors in MR applications

Mysegaes, Felix; Voigt, Pauline; Spiteller, Peter; Prediger, Isabell; Bernarding, Johannes; Plaumann, Markus

doi:10.1039/d3cc02724d

Cited by 1 publication

(1 citation statement)

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“…For the first time, viability studies from cell culture and complex stability tests were also able to provide information on future in vivo applications. [32,33] Investigations of fluorinated molecules that are not part of a ligand system were done by Lee et al in CDCl 3 . [31] They described the temperature effect i. e. for perfluorotributylamine that is also part of our study.…”

Section: Introductionmentioning

confidence: 99%

Organic Fluorine Compounds and Their Uses as Molecular MR‐Based Temperature Sensors

Bruns,

Ringleb,

Prediger

et al. 2023

ChemPhysChem

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The interest in fluorinated substances has increased significantly in recent decades due to their diverse properties and possible uses. An important analytical method in this context is NMR spectroscopy, which provides information on the structure as well as on intermolecular interactions or generally on changes in the environment of the nucleus under consideration. A physical quantity that is of great importance in most studies is temperature. However, this is not always easy, e.g. in shielded systems or within an organism. However, the application potential in chemical reactors or in medical diagnosis and therapy is very high and for this reason 13 fluorinated organic compound were chosen for a first 19F NMR signal temperature sensitivity examination for determination of local temperatures in solution. Polyfluorinated molecules with separate 19F MR signals are particularly suitable for temperature determination. Those can be serve as internal error‐correcting thermometers without the need of a reference substance. Under these conditions, a 19F MR signal shift of up to 0.03 ppm/K was detectable. Fluorine position and chemical environment were very important for the temperature sensitivity.

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Section: Introductionmentioning

confidence: 99%

Organic Fluorine Compounds and Their Uses as Molecular MR‐Based Temperature Sensors

Bruns,

Ringleb,

Prediger

et al. 2023

ChemPhysChem

View full text Add to dashboard Cite

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Two fluorinated thulium complexes as molecular temperature sensors in MR applications

Abstract: 19F-based magnetic resonance is a powerful tool to overcome several difficulties of standard 1H MR. We present the syntheses and characterization (including cell viability and stability tests) of two Tm3+...

Cited by 1 publication

References 48 publications

Organic Fluorine Compounds and Their Uses as Molecular MR‐Based Temperature Sensors

Organic Fluorine Compounds and Their Uses as Molecular MR‐Based Temperature Sensors

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