Two IL28B polymorphisms are associated with the treatment response of different genotypes of hepatitis C in different racial populations: A meta-analysis

Abstract

Abstract. The purpose of this present meta-analysis is to provide an accurate estimation of the association between two IL28B polymorphisms (rs8099917 and rs12979860) and sustained virological response (SVR) to standard treatment of patients of different racial descent infected with different genotypes of hepatitis C virus (HCV), and also to investigate the possible factors in the IL28B gene that contribute to the different SVR rates of patients with different subtypes of HCV infection across different populations. The electronic database PubMed was searched. Asian patients with a common homozygote (TT vs. TG/GG, OR=3.17; CC vs. CT/TT, OR=3.75) attained a higher rate of SVR, and a similar result was observed in European patients (TT vs. TG/GG, OR=1.74; CC vs. CT/TT, OR=2.50). Furthermore, HCV1-infected patients with a common homozygote (TT vs. TG/GG, OR=2.95; CC vs. CT/TT, OR=4.34) appeared to have a higher SVR rate than those with HCV2/3 (TT vs. TG/GG, OR=1.56; CC vs. CT/TT, OR=1.37). The frequency of the common homozygote in Asian patients was high, followed by European patients and African patients. In all, Asian patients attained a higher SVR rate than European patients (P<0.05). Patients with HCV1 infection had a lower SVR rate than those with HCV2/3 infection (P<0.001). Our results suggest that both the common allele frequency and racial descent itself contribute to the difference in SVR rates across different population groups, and the common allele frequency may partly elucidate the different SVR rates in patients with different genotypes of HCV.

Roles of ITPA and IL28B genotypes in chronic Hepatitis C patients treated with peginterferon plus ribavirin in Tunisian population

“…Viral kinetics were analysed as a function of these polymorphisms. Favourable genotypes (CC for rs12979860 and rs8099117 TT for) were associated with more rapid decline of viral load [22][23][24]. Similar data have already been reported by other teams and appear to be related to lower basal activation of IFN-Stimulated Genes (ISGs) for patients with a favourable IL28B polymorphism [25,26].…”

IL28Brs12980275 polymorphism shows association with response to treatment in Pakistani patients with Chronic Hepatitis C

“…The CC genotype was found in 26.7% of the nonresponders and 19% of responder patients. It has been reported earlier, that rs12979860 CC genotype has been significantly associated with sustained virological response in Asian, African, and European populations as compared to T allele carriers [Wu et al, ]. The frequency of CC genotype varies among different population; and was much higher in European patients than in African–American patients.…”

The role of IL‐28, IFN‐γ, and TNF‐α in predicting response to pegylated interferon/ribavirin in chronic HCV patients

“…Degree of fibrosis was also assessed by METAVIR score . Steatosis was graded according to the Brunt's grading system, based on percentage of involved hepatocytes in the biopsy specimen as follows: Grade 0 = none involved, grade 1 (mild) = up to 33%, grade 2 (moderate) = up to 66%, and grade 3 (severe) = more than 66% . These grades were grouped into three categories for statistical purposes as follows: grade 0, grade I , and grade II . Lymphoid aggregates, bile duct injury, and vascular changes were identified by their presence or absence.…”

“…The current standard therapy is based on a combination of pegylated interferon (Peg‐IFN) and ribavirin (RBV) . Many host and viral factors including the genotype of HCV and variation in certain genes influence the treatment response to Peg‐IFN and RBV combination therapy .…”