Two intertwined compartments coexisting in sporadic conventional colon adenomas

Rubio, Carlos A.

doi:10.5217/ir.2019.00133

Cited by 5 publications

(3 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Introductionmentioning

confidence: 99%

“…Adenomas and serrated polyps (SPs; sessile serrated lesion [SSL] and traditional serrated adenoma [TSA]) are precancerous lesions that can progress to colorectal cancer (CRC). [1][2][3] Therefore, polypectomy through colonoscopy is the most effective method to reduce the incidence and mortality of CRC. 4,5 However, since patients who undergo colonoscopic polypectomy have an increased risk of developing colorectal polyps www.irjournal.org ing to baseline polyp characteristics and new evidence on this topic, especially on the risk of metachronous CRC, are being reported, post-polypectomy surveillance guidelines have recently been updated by organizations in various countries.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Summary and comparison of recently updated post-polypectomy surveillance guidelines

Jung

2023

Intest Res

View full text Add to dashboard Cite

Recently, updated guidelines for post-polypectomy surveillance have been published by the U.S. Multi‐Society Task Force (USMSTF), the British Society of Gastroenterology/Association of Coloproctology of Great Britain and Ireland/Public Health England (BSG/ACPGBI/PHE), the European Society of Gastrointestinal Endoscopy (ESGE), the Japan Gastroenterological Endoscopy Society (JGES), and the Korean Multi-Society Taskforce Committee. This review summarizes and compares the updated recommendations of these 5 guidelines. There are some differences between the guidelines for the recommended post-polypectomy surveillance intervals. In particular, there are prominent differences between the guidelines for 1–4 tubular adenomas < 10 mm with low-grade dysplasia (nonadvanced adenomas [NAAs]) and tubulovillous or villous adenomas. The USMSTF, JGES, and Korean guidelines recommend colonoscopic surveillance for patients with 1–4 NAAs and those with tubulovillous or villous adenomas, whereas the BSG/ACPGBI/PHE and ESGE guidelines do not recommend endoscopic surveillance for such patients. Surveillance recommendations for patients with serrated polyps (SPs) are limited. Although the USMSTF guidelines provide specific recommendations for patients who have undergone SPs removal, these are weak and based on very lowquality evidence. Future studies should examine this topic to better guide the surveillance recommendations for patients with SPs. For countries that do not have separate guidelines, we hope that this review article will help select the most appropriate guidelines as per each country’s healthcare environment.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Summary and comparison of recently updated post-polypectomy surveillance guidelines

Jung

2023

Intest Res

View full text Add to dashboard Cite

show abstract

“…In similarity to polypoid conventional colon adenomas, 16 small nonpolypoid conventional adenomas (SNPCoAs) and nonpolypoid LST are built of two different histological compartments; the dysplastic compartment on top and the nondysplastic compartment below.…”

Section: Introductionmentioning

confidence: 99%

Two histologic compartments in nonpolypoid conventional colon adenomas

Rubio

2020

J of Gastro and Hepatol

Self Cite

View full text Add to dashboard Cite

Two intertwined compartments coexisting in nonpolypoid conventional (i.e. tubular or villous) adenomas are highlighted in this review: one built of dysplastic tissue on top and the other portraying crypts with irregular, corrupted shapes, albeit lined with normal epithelium, below. The latter compartment has remained unattended in the literature. Recently, however, the histologic characteristics of the nondysplastic compartment in nonpolypoid conventional adenomas were closely examined, and some of its biological attributes were unveiled. Studies with the proliferation marker ki67 showed that the crypts with irregular, corrupted shapes in the nondysplastic compartment displayed haphazardly distributed proliferating cell-domains. Given that the proliferating cells are generated by stem cells, the relocation of proliferating cell-domains in those crypts seems to be the result of a reorganization of the stem cells within the crypts. The abnormal distribution of proliferating cells, the finding of p53-upregulated cells, and of crypts in asymmetric fission suggest that the crypts in that compartment are histo-biologically altered, probably somatically mutated. This new information might contribute to unravel the riddle of crypto-histogenesis of nonpolypoid conventional adenomas of the colon. More research along these lines is necessary, before the biology of the crypts in the nondysplastic compartment can be fully translated into molecular terms.

show abstract

Asymmetric crypt fission in colectomy specimens in patients with ulcerative colitis

Rubio

Schmidt

2020

J Clin Pathol

View full text Add to dashboard Cite

AimsWe previously found colonic crypts with asymmetric fission bordering regenerating ulcers in ulcerative colitis (UC). The present objective was to assess the frequency of asymmetric crypt-fission in colectomy specimens from patients with long-lasting UC.MethodsH&E-stained sections from seven colectomies from patients with UC without dysplasia or carcinoma were investigated. Symmetric fission was characterised by branched colon crypts showing ≥2 identical crypts, whereas asymmetric fission exhibited branched colon crypt portraying ≥2 dissimilar crypts, differing in diameter, length and/or shape.ResultsThe number of crypts in fission in the 89 sections was 3586; of those, 2930 (81.7%) were asymmetric and the remaining 656 (18.3%), symmetric. Out of 927 vertically-cut crypts (in well-oriented sections), 912 (98.4%) were asymmetric, and the remaining 14 (1.6%), symmetric, and out 2660, cross-cut (transected) crypts in fission, 2018 (75.9%) were asymmetric and the remaining 642 (24.1%), symmetric.ConclusionCrypt fission is rarely found in the normal colon in adults. Symmetric crypt fission found in UC is possibly triggered by a compensatory homeostatic mechanism of crypt production in mucosal areas replaced by chronic inflammation. But asymmetric crypt fission is a pathological aberration that affects crypts in patients with a particular predisposition to develop mucosal dysplasia. It is suggested that this previously unattended histological parameter be included in the pathological descriptions of colectomy specimens from patients with UC.

show abstract

Two intertwined compartments coexisting in sporadic conventional colon adenomas

Cited by 5 publications

References 49 publications

Summary and comparison of recently updated post-polypectomy surveillance guidelines

Summary and comparison of recently updated post-polypectomy surveillance guidelines

Two histologic compartments in nonpolypoid conventional colon adenomas

Asymmetric crypt fission in colectomy specimens in patients with ulcerative colitis

Contact Info

Product

Resources

About