Two Lozenges Containing Benzocaine Assessed in the Relief of Sore Throat

Kagan, G. Ya.; Huddlestone, L; Wolstencroft, Paul

doi:10.1177/030006058201000611

Cited by 9 publications

(10 citation statements)

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“…The onset of worthwhile pain relief was about 20 min with benzocaine lozenges and significantly shorter than with placebo lozenges. Rapid onset of pain relief had also been observed in previous studies comparing different topical benzocaine preparations for the same condition [8,9]. The effect of the 8 mg benzocaine lozenge lasted around 100 min.…”

Section: Discussionsupporting

confidence: 67%

“…(1) participation in another clinical trial within 30 days beforehand, (2) actual or possible pregnancy, or lactation, (3) any suspicion of drug or alcohol abuse, (4) history of allergy to the study medication, (5) any severe chronic disease, (6) any current pain treatment--whether analgesics or nonsteroidal analgesics (NSAIDs), (7) treatment with steroids, oro-pharyngeal therapeutic agents, anticonvulsants, psychotropic or immunosuppressant agents within 24 h (or, with prolonged action NSAIDs, within 10 days), or antibiotics within the 14 days up to enrollment, (8) known or suspected bacterial infection, (9) known or suspected NADH-diaphorase deficiency. After patients had given informed written consent, their age and gender were recorded along with their medical and surgical history and the results of a general physical examination that included their height, weight, sitting blood pressure and heart rate.…”

Section: Methodsmentioning

confidence: 99%

“…Kagan and co-workers [8] compared in a single-blind study, two doses of benzocaine in a mixture with an antiseptic. The 10 mg benzocaine dose was more effective than half dose.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of a benzocaine lozenge in the treatment of uncomplicated sore throat

Chrubasik

Beime²,

Magora

2011

Eur Arch Otorhinolaryngol

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Benzocaine lozenges are popular in symptomatic treatment of acute sore throat. The aim of this study was to evaluate if sucking a benzocaine lozenge was superior to a placebo lozenge in patients with pain while swallowing. Volunteers with acute, uncomplicated sore throat received randomly and double-blind either a benzocaine 8 mg or a placebo lozenge. Pain was assessed on a numerical visual rating scale. The primary outcome measure was the sum of the pain intensity differences (SPID) over 2 h. Secondary outcome measures included the number of patients who reported 50% or more of their baseline pain score (responders) and those with worthwhile and complete pain relief, the times to worthwhile/complete pain relief and to pain recurrence and the occurrence of any adverse effects. A predefined interim analysis after including 50 patients revealed the superiority of benzocaine versus placebo in the SPID (p = 0.0086). At this time, a total of 165 patients had been recruited (full analysis set, FAS) and underwent statistical analysis. In the FAS, median SPID had significantly more decreased in patients receiving benzocaine compared to placebo (-12 vs. - 5, p = 0.001). There were significantly more responders and patients with worthwhile pain relief in group benzocaine. The number of patients with complete pain relief was very small. Median time to worthwhile pain relief was 20 min (benzocaine) and >45 min (placebo). Adverse events were not observed. Benzocaine lozenges are superior to placebo lozenges and a useful, well-tolerated treatment option to reduce painful pharyngeal discomfort.

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Section: Discussionsupporting

confidence: 67%

Section: Methodsmentioning

confidence: 99%

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Efficacy of a benzocaine lozenge in the treatment of uncomplicated sore throat

Chrubasik

Beime²,

Magora

2011

Eur Arch Otorhinolaryngol

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“…Local NSAIDS such as ibuprofen [63] and flurbiprofen [64,65,66] have been proposed, but concern has been expressed that the benefit of their local action might be too small in comparison to the risk related to their untoward systemic effects [67]. Alternatively, local anaesthetics [68,69] such as lidocaine [70] and benzocaine [71,72] are often used also to prevent postopera-tive sore throat resulting from the irritation by endotracheal intubation [73,74]. However, such local anaesthetics may cause to several side effects [75]: sensitisation [76] and methaemoglobulinaemia [77][78][79]) have been reported; additionally, the amount of benzocaine in several lozenges is probably too small to be of real benefit [80].…”

Section: Non-antibiotic Treatments For Sore Throat?mentioning

confidence: 99%

Efficacy and Safety of Ambroxol Lozenges in the Treatment of Acute Uncomplicated Sore Throat

Mey

Peil

Kölsch

et al. 2011

Arzneimittelforschung

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Sore throat is the hallmark of acute pharyngitis. Although usually caused by viral infections, it is frequently treated with antibiotics. Such inappropriate use of antibiotics might best be challenged by offering efficacious and safe symptomatic pain relief instead. However, there is need for robust evidence to support such alternatives. Presently, the evidence from randomised, placebo-controlled, double-blind clinical trials (RCT) with the local anaesthetic ambroxol (CAS 23828-92-4) in the treatment of sore throat is being reviewed. This relates to five RCT in 1,772 patients; 1,713 were evaluable with regard to efficacy. Treatment with ambroxol lozenges was statistically significantly superior to placebo in reducing sore throat pain intensity with a high level of consistency of the estimated effect across the different studies. The effect had an early onset and lasted up to at least 3 h after a single first lozenge. The pain relief was associated with a statistically superior regression of pharyngeal redness and inflammation; with ambroxol, the overall efficacy was more frequently rated as at least "good". Treatment with the ambroxol lozenges was well tolerated. There was heterogeneity in reporting adverse events: in one later study with less severe baseline pain intensity there was more frequent reporting of hypoaesthesia of the oral cavity and tongue as an untoward phenomenon. In patients with more severe baseline pain this reflection of the medication's pharmacological action was only rarely reported as untoward. It is concluded that lozenges containing 20 mg ambroxol are a safe and efficacious treatment for acute uncomplicated sore throat of recent onset in adult patients.

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“…Although this complaint is generally of viral origin and heals spontaneously, the discomfort is such that most patients are likely to seek symptomatic relief by medication. Local anaesthetic medications containing lidocaine or benzocaine [1] are commonly used to enges per day, a statistically significantly higher proportion of patients scored a higher level of efficacy for the active treatments with ambroxol hydrochloride compared to placebo. The treatments investigated were equally well tolerated.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Tolerability of Ambroxol Hydrochloride Lozenges in Sore Throat

Fischer¹,

Pschorn

Vix

et al. 2011

Arzneimittelforschung

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Sucking lozenges containing 20 mg or 30 mg ambroxol hydrochloride has a beneficial pain-relieving effect in patients with acute sore throat, superior to that achieved by sucking a placebo lozenge. While both strengths were equally well tolerated, the higher strength of 30 mg ambroxol hydrochloride did not prove more effective. The findings confirm that the previously discovered local anaesthetic properties of ambroxol hydrochloride do have beneficial clinical implications.

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Two Lozenges Containing Benzocaine Assessed in the Relief of Sore Throat

Cited by 9 publications

References 0 publications

Efficacy of a benzocaine lozenge in the treatment of uncomplicated sore throat

Efficacy of a benzocaine lozenge in the treatment of uncomplicated sore throat

Efficacy and Safety of Ambroxol Lozenges in the Treatment of Acute Uncomplicated Sore Throat

Efficacy and Tolerability of Ambroxol Hydrochloride Lozenges in Sore Throat

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